1. can be complicated with secondary diabetes or impaired glucose tolerance, hypertension, myocardial hypertrophy and ventricular hypertrophy, and can develop into heart failure and arrhythmia.

2. Pituitary tumor compresses optic chiasm, swelling, decreased vision, narrowed visual field and even increased intracranial pressure near sella turcica. Obesity, sleep disorder, diabetes insipidus, etc

3. Osteoporosis can be complicated with kyphosis and even pathological fracture. Because the optic nerve is compressed by adenoma, it causes blood circulation disorder, which may be complicated with optic nerve atrophy, decreased vision and visual field defect, such as bilateral temporal hemianopia. Osteoarthritis.

Personally, evolution refers to the variation of individual morphological structure, physiological characteristics, behavior habits and other characteristics that are more suitable for survival than before (refers to the variation of the same traits in different environments, which may not be called excellent traits for individuals. For example, fur is not a good trait for African elephants, but it is a good trait for mammoths. )

In short, gigantism is not adapted to the present environment, so it cannot be called evolution.