2, and tobacco "joint role" cancer, simply chewing betel nut can significantly promote the occurrence of oral cancer, and at the same time smoking betel nut enthusiasts have a higher incidence of oral cancer. Smoking itself is also a separate risk factor for oral cancer. Chewing betel nut containing tobacco, the toxic substances in saliva will be significantly elevated, on the cell DNA synthesis and other processes have a significant destructive effect.

3, alkaloids have "poison" betel nut contains a large number of polyphenols and a variety of alkaloids, of which betel nut alkali is the most important component, about 1% of the net weight of dry betel nut. Betel nut alkaloids can significantly promote apoptosis of epithelial cells, and interfere with the extracellular matrix macromolecules (collagen, elastin, etc.) precipitation and degradation process.