2 the role of moxa powder
[1] Folium Artemisiae Argyi powder is a part of Folium Artemisiae Argyi, which has the functions of dispelling cold and relieving pain, warming meridians to stop bleeding, warming middle warmer to dispel cold, eliminating dampness and treating various diseases.
The powder contains crude fat, crude protein, carbohydrates, vitamins, minerals and essential amino acids for livestock and poultry.
Pictures of moxa powder (2 photos)
It contains chlorophyll. Adding proper amount of moxa powder into livestock feed can prevent diseases, enhance the physique of livestock and poultry, and promote the growth and development of livestock and poultry.
The moxa smoke produced by burning moxa powder has the function of sterilization and disinfection. The ancients used moxa smoke to prevent plague, and modern hospitals also used it to disinfect indoor air, so as to reduce the spread of iatrogenic bacteria and control cross infection.
Using the efficacy of wormwood, soaking feet with wormwood powder can effectively eliminate deficiency fire and cold fire, and can treat oral ulcer, gingivitis, sore throat, periodontitis, otitis media and other head and face recurrent diseases related to cold fire and deficiency fire.
borneol
Add meaning
Borneolum Syntheticum, alias: borneol, borneol, borneol, borneol, plum blossom brain, natural borneol, old plum slice and plum slice. Main ingredients: this product is a crystal obtained from the resin and volatile oil of borneol, almost pure dextroborneol. There are many terpenoids in the resin and volatile oil of borneol. Besides borneol, there are sesquiterpenes such as humulone, β-elemene and caryophyllene, and triterpenes such as oleanolic acid, Grifolate acid, Asiatic acid, borneol, borneol and coca alcohol.
Basic information
The branch of academic or vocational research.
Dipterocarpaceae
Another name
Brain slice, orange slice, borneol, plum blossom borneol
boundary
plant kingdom
belong to
kapur
Distribution area
Guangdong, Guangxi, Yunnan, Guizhou
Chinese name
borneol
Foreign name
DryobalanopsaromaticaGwaertn.f
catalogue
launch
1 Basic introduction
2 Introduction of Borneol
3 Plant introduction
3. 1 geographical distribution
4 historical records
5 Introduction to Chinese Medicine
5. 1 sexual taste
5.2 Function indication
5.3 Selection of political parties
5.4 borneol taboo
5.5 Modern research
5.6 Main components:
5.7 Pharmacological effects:
6 related introduction
6. 1 medicinal value
6.2 properties of borneol
6.3 quality standards
6.4 Compatibility Effect
6.5 Pharmacokinetics
6.6 Pharmacology (Toxicology)
Basic introduction
Borneol, also known as borneol, orange slices, borneol, plum blossom borneol, Jiebuxiang, plum blossom borneol, borneol, plum ice and so on. , which is a crystal obtained by extracting resin and volatile oil from borneol, is almost pure D-borneol. It can also be synthesized by chemical methods.
Introduction of borneol
Borneolum. Alias: Borneolum Syntheticum, Borneolum Syntheticum, Brain, Borneolum Syntheticum, Plum Blossom Brain, Natural Borneolum Syntheticum, Lao Mei Pian and Mei Pian. The main components are borneol resin and crystals obtained from volatile oil, which are close to pure dextroborneol. There are many terpenoids in the resin and volatile oil of borneol. Besides borneol, there are sesquiterpenes such as humulone, β-elemene and caryophyllene, and triterpenes such as oleanolic acid, Grifolate acid, Asiatic acid, borneol, borneol and coca alcohol.
Main ingredients: this product is a crystal obtained from the resin and volatile oil of borneol, almost pure dextroborneol. There are many terpenoids in the resin and volatile oil of borneol. Besides borneol, there are sesquiterpenes such as humulone, β-elemene and caryophyllene, and triterpenes such as oleanolic acid, Grifolate acid, Asiatic acid, borneol, borneol and coca alcohol.
Description: It is a translucent block and flake crystal similar to plum petals, so it is called "plum slice"; The diameter is 0. 1~0.7cm and the thickness is about 0.1cm. . White to taupe, fragrant, cool, slowly melting when chewing. No black smoke or slight black smoke when burning.
Oral administration and dosage: take pills and powder, 0.5 ~ 1 min. External use: grinding, spraying or application.
Avoid: people with deficiency of both qi and blood should avoid taking it; Pregnant women should take it carefully.
Classic of Materia Medica: "Anyone who has a stroke, who is not exogenous pathogenic wind and is sick due to deficiency of qi and blood, should avoid it;" Children who become frightened after vomiting and diarrhea have a slow spleen wind and must not take it. Acute shock is true heat, and slow shock is deficiency cold. Those with dim eyes and liver and kidney deficiency should not take some medicine. "
Plant introduction
Borneol incense (Tang Materia Medica), also known as bone-unbreakable method (Youyang Miscellanies) and Jiebuxiang (Materia Medica).
Evergreen tree, 5 meters high, smooth and hairless, with concave cracks on the bark and hard borneol crystals outside. Leaves alternate and leathery; Petiole stout; Leaf blade ovoid, apex pointed: base obtuse or broadly cuneate, entire, glabrous on both sides, shiny, main vein obvious, lateral vein pinnate, apex connected near leaf margin. Panicle, inserted between the axils of upper branches, with bisexual and neat flowers; Receptacle fleshy and slightly concave; Calyx 5, arranged in imbricate shape, continues to grow after flowering; Petals 5, white; Stamens are numerous, free, slightly circumferential, anthers linear, anthers inward, margin dehiscent, connective elongated in a pointed tail shape, filaments short; Pistil 1, composed of 3 carpels, superior ovary, axial placentation, 3 cells, 2 ovules per cell, filiform style. The dried fruit is ovoid, leathery and indehiscent. Receptacle barrel-shaped, with 5 persistent calyx wings at the edge. 1 ~ 2 seeds have endosperm. Distributed in the area of Nanyang Islands. The resin (borneol paste) and seed (borneol seed) of this plant are also used as medicine, and each has its own article in detail.
geographical distribution
Resin processed products, or crystals obtained after distillation and cooling of borneol trunk, are called "borneol" and "plum slices". It is made by DC sublimation of blumea balsamifera leaves. , a perennial herb of Compositae, is called "Aipian". At present, turpentine, camphor and so on. Borneol synthesized by chemical method is called "mechanism borneol". Dipterocarpaceae plants are mainly produced in Southeast Asia, and also introduced in Taiwan Province Province of China. Blumea balsamifera is mainly produced in Guangdong, Guangxi, Yunnan, Guizhou and other places. Finished borneol should be stored in a cool place and sealed. Used for grinding powder.
Terpene. The molecular formula is C 10H 18O. Also known as borneol or 2- borneol. White translucent hexagonal crystals, like the smell of camphor. Dextroborneol is a foliate or hexagonal flaky crystal; Melting point 208℃, boiling point 2 12℃, relative density1.01(20/4℃), specific rotation +37.7 (ethanol); Soluble in ethanol, ether and benzene. L-borneol is a hexagonal flaky crystal; Melting point is 208.6℃, boiling point is 210℃ (779mmhg), and relative density is1.1(20/4℃), -37.74 (ethanol); Soluble in ethanol, ether, acetone and benzene. Racemic borneol is a leaflike crystal; Melting point 2 10.5℃, easy to sublimate, relative density1.01(20/4℃); Soluble in ethanol, ether and benzene. Camphor is produced after oxidation. Borneol can be reduced by camphor in ethanol solution containing sodium metal; Or pinene is esterified with oxalic acid in the presence of a catalyst and then hydrolyzed. Borneolum Syntheticum is widely used to prepare the essence of rosemary and lavender, and also used in traditional Chinese medicine and China ink stick.
history
1. "Miscellaneous Notes on the West": "Borneolum incense tree, for the benefit of women, is not a female law. Also from the Persian kingdom, the tree is eight feet high and can surround six or seven. The leaves are round and white and there are no flowers. Its trees are fat and thin, the thin ones exude borneol fragrance, and the fat ones exude sesame oil fragrance in the wood heart. Persia cut down its tree, cut it down, and its green color flowed out at the end of the tree, and the tree used it as a barrier. There are other ways to take medicine. "
2. Newly revised materia medica: "The tree looks like a fir, which is the essence of the law. It is the fat under the root, and borneol is the dry fat in the root. Children are like cardamom, but the skin is wrong. It smells like borneol, pungent, especially unpalatable and fully digested. It's Xiang, the old cloud goes abroad. The medicine is named after China, that is, snow pine resin. There are Chinese fir in Jiangnan that have not been tested. " Or the soil is fat-free, and bananas are not real. "
3. Materia Medica: "Borneolum went out of France, and now only the South China Sea is left. According to legend, its wood is seventy or eighty feet high, and it can be circled six or seven times. It is like a cedar tree with branches and leaves beside it. Round and white, as strong as cardamom, with the wrong skin. Incense is the fat in wood, like white turpentine, used as cedar gas; Ointment is a transparent liquid under the root of the ear, also called ear wax ointment ... This kind of wood is also found in seamounts in Yunnan. In Tang Tianbao, the cross-toed dragon brain is like cicada and silkworm, but he used to have it, which is extremely rare. When it is forbidden, it is called Rui Longnao, clothing and clothes. It smells more than ten steps away, but it doesn't smell after that. At present, most of Hainan's borneol is refined by fire, and there are also impurities and fakes. " Only medicine is expensive, and it looks like plum petals. "The brain enters the heart meridian, and non-borneol can enter the heart." (summary)
4. Miao Xiyong: "Borneolum, its fragrance is the crown of all medicines. Anyone with a strong aroma will be warm in essence, while Li Xun's speech is warm and the elemental speech is hot. Strong fragrance, pungent taste, yang in the yang, rising and dispersing, good in nature, invincible, fragrant in gas, can dispel all evils, pungent in heat, and disperse rheumatism, so pathogens and rheumatism accumulate in the main heart. Deaf people are also closed, and their ears are self-listening when they are enlightened; Eyes covered with red skin, very hot, pungent warmth dominated the dispersion. If we can draw the fiery qi out from the outside, it goes without saying that the skin is covered with red pain. This is also a cure. " "Beru" also shows that housewives who are in dystocia take advantage of it and open their ears to listen to the truth. "("Materia Medica ")
5. Ni Zhu Mo: "Borneolum Syntheticum, the medicine to enlighten and ward off evil spirits, is good at escaping, enlightening and understanding, all the way. However, the gas of incense can dispel all evils, and the work of Xin Lie dissipates all wind and heat. Therefore, Tang Materia Medica is mainly characterized by red eyes, swelling and shame, or swollen throat, stagnant water and slurry, or headache caused by brain wind, nasal cavity and paranasal sinuses, or swelling and pain of external hemorrhoids, blood dripping, or bone intercourse, dystocia, or wind poisoning into the bone, numbness and colic, or acne toxin adduction, which is annoying. " This medicine is pungent, fragrant, strong, dispersing and hydrophobic, and it is extremely effective. All the diseases of sudden death, suffocation and phlegm and blood stasis can't be cured unless this is the case. "("Materia Medica ")
6. Zhang Jingyue: "The taste is slightly sweet and pungent, and it is as cold as ice, but it is very energetic and sharp. Not hot, there is yin in the yang. Be good at dispersing qi, blood, fire, stagnation, brightness and evil, and drive away evil spirits in your heart. " (Ben Cao Zheng)
7. Liu Ruojin: "Borneolum, what disease does it treat, such as Zong? #93; The so-called sparse heat insulation plug, the so-called sparse heat dissipation, holiday fasting and gas stagnation, the so-called catalpa bungeana gas stagnation and heat generation, can be opened when it is lifted, because it is stagnant, beneficial and stagnant, and it can't be cured. What's more, it is based on rules, which has both good and bad sides. So, if the larynx is swollen and blocked, and adults and children are blocked by the wind, how can we save the day? Another example is children's nasal cavity, tongue swelling, conjunctival congestion, chancre, hemorrhoids, acne and so on. Why is the heat because of blood? It's really the heat! If it is applied according to symptoms, it is not appropriate. Another example is the shortage of categories, and the seedlings have also been cut down. I don't know that phlegm and saliva are rising with the wind, but they can't dispel the smell of opening and closing. Where can he start? That is to say, phlegm and saliva should be removed, but it can be removed first and then, which is not as effective as treatment. Although this taste is almost pungent, it is. " The first thing is to spread out from the inside out, there is nothing inside and there is nothing outside. Those who are trapped, tied and closed can disperse according to their sufferings. "(Materia Medica)
8. WANG Bi: "Borneolum Syntheticum, pungent, fragrant, solid ... or if it is suspected that pungent flavor tonifies the liver and the aroma belongs to Yang, it is not cold. I don't know that yin and yang can be divided into yin and yang ... Yujin is cold, plum blossoms are cold and fragrant, not to mention spicy and fragrant, and cold fragrance is the yang ear in yin ... Borneolum can dispel depressed fire, remove heat through bones, and treat convulsions, epilepsy, phlegm, laryngitis, tongue swelling, toothache, deafness, stuffy nose and red eyes. " But it is easy to exhaust when it is scattered, but it will eventually be cloudy and cold. "(Compilation of Medicinal Forests and Medicinal Properties)
9. Application and usage of borneol.
9. 1 Li Dongyuan: "Borneolum goes deep into the bone marrow, so it should be used by patients with wind disease. If the wind is in the blood muscle, it is replaced by brain and musk deer, and the wind enters the bone marrow. If oil enters the surface, it will not come out. " (Quoted from "Outline" 9.2 Ni: "However, drugs that are often taken, such as drugs for adult wind and saliva block, drugs for severe heat shock, such as drugs for chronic wind-induced arthralgia, drugs for slow shock after vomiting and diarrhea, cannot be used; Eyes Eyes can be used for patients with sudden heat such as deficiency of liver and kidney essence and blood, but not for those with blurred eyes; Wind pain can be used in bone marrow, not in blood vessels and muscles. " However, everyone knows that it is cool and beneficial, but it flies lightly before it is hot. I like its fragrance and expensive, and I often use musk to help. However, the human body's yang is easy to move and yin is easy to lose, so we must not be careless. "("Materia Medica ")
9.3 Zhang Jingyue: "Anyone who uses this product should use it with caution and temporarily, while others will disperse the true qi, which is harmful to people." (Ben Cao Zheng)
9.4 Topaz: "Borneolum Syntheticum is pungent, warm in nature, fragrant in taste and moving qi. Syndrome such as phlegm due to wind, internal resistance of middle energizer, etc., are temporarily searched for evil by opening and closing. However, the fragrance is so rampant that people die suddenly. " It is only used for external symptoms, such as eye drops and throat blowing. , or for Xin San, or for relying on its fragrance to open the ear. "("Reading Classics ")
Introduction to traditional Chinese medicine
① Borneolum Syntheticum: also known as Borneolum Syntheticum (not recorded), Borneolum Syntheticum (Fang Fang), Borneolum Syntheticum (Herbal Medicine), Plum Blossom (Jian Yizhi), Plum Blossom (Defending the Divine Prescription) and Borneolum Blossom (Plum Blossom Blossom Blossom (Plum Blossom Blossom Blossom). It is a processed product of borneol resin. It is translucent, blocky, flaky or granular, with a diameter of 1 ~ 7mm and a thickness of about 1mm, and it is grayish white to grayish brown. The breath is fragrant, not cold, but slowly melts when chewing. After micro-sublimation, its crystals are rod-shaped or polygonal under the microscope. No black smoke or slight black smoke when burning. It is best to have a large and thin sheet with white color, loose texture and pure fragrance. Mainly produced in Sumatra, Indonesia and other places.
② Mechanism borneol synthesized by chemical method. It is a translucent flaky crystal with a diameter of 5 ~ 15mm and a thickness of about 2 ~ 3 mm. White, with cracks like ice on the surface. Crispy and layered, it can be peeled into thin slices and crushed by hand. The smell is fragrant and the taste is spicy and cool. There is black smoke when burning, and there is no residue.
Produced in Shanghai, Tianjin, Nanjing, Guangzhou and other places.
There is also a crystal extracted from the leaves of blumea balsamifera in Compositae, commonly known as Aipian. It is also used as a kind of borneol in commodities.
Sexual taste
Hard and cold.
① Tang Dynasty Materia Medica: "Bitter taste, slightly cold." ② Materia Medica of Haiyao: "Bitter and pungent, slightly warm and nontoxic."
③ Zhang: "Hot."
(4) Ben Feng Jingyuan: "Hard, warm and toxic."
Meridian tropism
Into the heart and lungs.
① Outline: "Lung, heart and spleen."
② Description of the Properties of Leigong's Processed Drugs: "Entering the Lung and Liver Meridian."
Functional indication
Dredging orifices, purging fire, eliminating nebula, improving eyesight, reducing swelling and relieving pain. Can be used for treating moderate-warm wind, fever, dizziness, convulsion, phlegm retention, deafness due to qi obstruction, laryngitis, aphtha, otitis media, carbuncle, hemorrhoid, conjunctival congestion and pinworm disease.
(1) Bielu: "When a woman has dystocia, grind a little borneol and adjust it with new water."
(2) Tang Materia Medica: "Master and friend are evil, rheumatism, deafness. Clear your eyes and go red. "
③ Materia Medica of Haiyao: "Treating internal and external eye obstruction, three worms, five hemorrhoids, improving eyesight, calming the heart and storing secret essence."
④ Zhang: "Treating prolapse of large intestine."
⑤ Gaoli: "Treating bone pain."
⑥ Wang: "Relaxation is full of calories."
⑦ "Outline": "Treat laryngitis, brain pain, nasal breathing, toothache, typhoid fever, tongue tip, acne and depression in children." Dreadful and depressed. "
⑧ Compendium of Materia Medica: "Treating convulsion, epilepsy and phlegm fan."
Doctor's mirror: "cure limb pain."
Party selection
① Acute stroke can't be prescribed: Rhizoma Arisaematis (crushed into fine powder) and Borneolum Syntheticum (researched separately). Take two flavors, divide them evenly, carefully regrind them, give directions in the middle to disperse the seeds, rub them around the big teeth for 30 or 20 times, and then open your mouth by yourself before you can prescribe the medicine. The patient only spends one word to half a dollar. ("Sheng Ji Zong Lu" switch scattered)
(2) When cured, he suffered from pea sores and red sores, upset and irritable, and gasped. He lied: borneol is a dollar. Fine grinding, spinning pig blood and pills, such as chicken head. Every time I take medicine, I feel very calm when I am young and want to sleep. If the sore recurs completely, you can take the rest as usual. ("Experience behind") 3 Treating heart heat, unconsciousness, or taking hot drugs, being ignorant of people, and having a dark rash: Is raw borneol (research) a word or a word? Take a new pig-killing heart, grind it into a big pill with painstaking efforts, dissolve it with a little new water, and take it again without saving it; Such as sores and rashes, warm wine melts. (Prescription of Pediatric Medical Certificate)
(4) For typhoid patients with excessive tongue coating: Borneolum Syntheticum is half a point, which is the end, and mixed with it. (Jane Yizhi)
⑤ Treatment of head wind-heat attack: borneol and half, one or two of Nanpengsha. Two noses often twitch. (Imperial Medical Hospital)
⑥ Treatment of headache: Borneolum Syntheticum is a money, paper roll is a whip, sniffling, spitting, and healing. (Shouyu Shenfang)
⑦ Treatment of wind-heat laryngitis: wick is one yuan, cortex Phellodendri (calcined) is five points, alum (calcined) is seven points, and borneol is three points. To end it. Blow the affected area with one or two points at a time. ("lakeside collection simplified formula")
⑧ For the treatment of long-term swelling and pain in throat and mouth, and pain caused by long-term expectoration and fire, borneol is five points, cinnabar is six points, and sodium sulfate and borax are five yuan each. * * * ground into fine powder, then blown, or even rubbed five or six times a day. ("Surgical Authentic" Bingpeng Powder)
⑨ Curing aphtha and dry throat: Borneolum Syntheticum, San Qian and Cortex Phellodendri. For the end, honey pills are big, take ten pills every winter soup. (Picking Fiona Fang)
Indications for internal hemorrhoid and external hemorrhoid: Borneolum Syntheticum is divided into one part and two parts, and onion juice is coated on it. ("purely unilateral")
⑾ Treating red-eye pain, sudden floating white nebula: one point for borneol and one point for male bird droppings. Grind the last medicine into powder, mix it with human milk, make it into paste, and take it off little by little with copper chopsticks. ("Sheng Huifang" borneol ointment)
⑿ Treat your nose with wine, and pay attention to the red blisters on your face: the brain is really brittle and coated. (Shipping party)
[13] toothache: borneol and cinnabar. Finally, everyone wipes a little. ("lakeside collection simplified formula")
[14] Treatment of nasal polyp ptosis: Point on the brain. ("lakeside collection simplified formula")
⒂ Treatment of burns and scalds: borneol10g, cinnabar 5g and sesame oil100ml. First, pour sesame oil into aluminum pot to boil, then add cinnabar and borneol, and heat until it is reddish brown and becomes a paste. Sterilize the wound and apply it once a day. (Selected data of new medical methods of Chinese herbal medicines in Liaoning)
Borneol taboo
Yin deficiency and hyperactivity of yang, slow cooling in children, diarrhea due to spleen deficiency, deficiency of liver and kidney, and eye diseases should not be taken, so pregnant women should use it with caution.
Modern research
Main ingredients:
Synthetic borneol mainly contains borneol (59.78% ~ 58.93%), isoborneol (38.98% ~ 37.52%) and camphor (2.70% ~ 2.09%). Almost pure dextroborneol. There are many terpenoids in the resin and volatile oil of borneol. Besides borneol, it also contains sesquiterpenes, such as humulone, β-elemene, caryophyllene, oleanolic acid, phenolic acid, Asiatic acid, borneol, triterpenes such as hydroxydamenone II, Dryobalanone and coca glycol.
Pharmacological action:
1. In vitro antibacterial and anti-inflammatory effects experiments show that higher concentration of borneol (0.5%) has antibacterial effects, synthetic borneol and natural borneol have the same antibacterial effects, and borneol and isoborneol have antibacterial effects. It can also significantly inhibit egg white paw swelling in rats; Isoborneol can also inhibit the auricle swelling of croton oil, suggesting that they can inhibit the swelling process such as fluid exudation and tissue edema.
2. Effect on Pregnancy Animal experiments show that borneol has no obvious induced labor effect on mice in the early pregnancy, but it has obvious induced labor effect on mice in the middle and late pregnancy. It is reported that borneol can be used as an antifertility drug, and vaginal suppository can improve its bioavailability and enhance its antifertility effect. The application of water-soluble matrix and proper amount of surfactant in the matrix of borneol vaginal suppository is beneficial to the release of borneol.
3. Other animal experiments show that borneol and isoborneol can prolong the hypoxia tolerance time of mice. Comparatively speaking, the effect of isoborneol is remarkable, but borneol is not. The effect of Isoborneol on improving hypoxia tolerance and prolonging hypoxia survival time in mice may be related to its great fat solubility. Borneol can affect the activity of adrenoceptor, but whether it is related to prolonging hypoxia tolerance time needs further study.
Studies have shown that Guanxin Suhexiang Pill can reduce the heart rate, improve coronary flow and reduce myocardial oxygen consumption in dogs with experimental myocardial infarction. According to the resolution analysis, storax and borneol play the main roles.
Borneol and Isoborneol can significantly prolong the sleep time induced by pentobarbital in mice, and have synergistic effect with pentobarbital, especially Isoborneol. The results showed that borneol could pass through the blood-brain barrier and accumulate in the central nervous system within 5 minutes after oral administration. It is suggested that isoborneol and isoborneol can prolong the sleep time induced by pentobarbital in mice, and its action site may be in the center. Isoborneol is more soluble in fat and can easily enter the center through the blood-brain barrier to play its role.
It is reported that borneol can be used for neuropathic pain, but it has some analgesic and mild antiseptic effects. The local stimulation test showed that the dosage of borneol and isoborneol was 5 ~ 10 times of that of human, but the stimulation was not serious, so it was suggested that administration through mucosa or muscle could be considered. Borneol is easily absorbed in mucous membrane and subcutaneous tissue, and is excreted after combining with glucuronic acid in the body.
In vitro, 60% ~ 100% glucuronic acid conjugate was excreted in 24 hours after oral administration of borneol 1g in normal people. Experiments in rats show that glucurolactone or sodium glucuronate can antagonize the toxicity of borneol.
Related introduction
Medicinal value
1. Newly revised materia medica: "Treat evil spirits, accumulate rheumatism, deafness, improve eyesight, remove red eyes and skin nebula." Compendium of Materia Medica: "Treat throat obstruction, brain pain, nasal atrophy, toothache, typhoid fever with tongue, acne and depression in children.
Clearing orifices and dispersing depressed fire. "
Medical Forest Compilation: "Borneolum Syntheticum can dispel depressed fire, penetrate bone heat, treat convulsion, epilepsy, phlegm, laryngitis, tongue swelling, toothache, deafness, nasal polyps, floating eyes, acne toxin invagination, insecticidal, hemorrhoids, promote pregnancy, prevent sexual intercourse, promote granulation and relieve pain. However, if it is scattered and easy to exhaust, there will eventually be a cold time. "
2. Borneol contains D-borneol, terpenoids such as luteolin, β-elemene and caryophyllene, and triterpenes such as oleanolic acid, Bai Mei acid, asiatic acid, borneol and coca alcohol. Aipian contains L-borneol. The mechanism of borneol is racemic mixed borneol. The local application of borneol has slight stimulation to sensory nerves, and has certain analgesic and mild antiseptic effects. It can be absorbed rapidly through mesentery, and can pass through the blood-brain barrier within 5 minutes after administration, and can be accumulated in the brain for a long time, and the amount is quite high, which provides a preliminary experimental basis for the aromatic resuscitation effect of borneol. Higher concentration (0.5%) has inhibitory effect on Staphylococcus aureus, Streptococcus, Pneumococcus, Escherichia coli and some pathogenic dermatophytes. It can induce labor in mice in the second and third trimester of pregnancy.
Borneolum Syntheticum is a processed product of Dipterocarpaceae, which contains D-borneol, β-elemene, caryophyllene and so on. Pungent in taste and cold in nature, it has the functions of inducing resuscitation, dispersing depressed fire, reducing swelling and removing phlegm. In the beauty prescription, it is used to treat halitosis, body qi, sores, swelling and furuncle caused by blood heat and internal heat.
Borneol property
Borneolum Syntheticum is colorless, transparent or white translucent flaky brittle crystal; The gas is fragrant, pungent and cool;
Volatile, easy to sublimate, ignited to produce smoke, light and flame.
This product is soluble in ethanol, chloroform, gasoline or ether, and almost insoluble in water.
The melting point and boiling point of D-borneol are 208℃ and 265,438 02℃, and that of L-borneol is 204℃ and 265,438 00℃.
quality standard
(China Pharmacopoeia 2000 Edition)
Appearance:
Melting point: 205-2 10℃
Logo:
Color Reaction of Vanillin Sulfuric Acid
Camphor odor reaction
Check:
PH value: Phenolphthalein and methyl red should not be red.
Non-volatile matter: less than 0.035%
Moisture: The petroleum ether solution should be clarified.
Heavy metal: no more than 5ppm.
Content determination:
The calibration factor was calculated by gas chromatography with methyl salicylate as internal standard and borneol standard. The content of borneol in the sample was not less than 55%.
Compatibility effect
Borneolum Syntheticum and Cortex Phellodendri: Borneolum Syntheticum is bitter in taste, cool in nature, good at inducing resuscitation, dispersing depressed fire and improving eyesight, and can clear away heat and reduce swelling, relieve itching and relieve pain for external use; Phellodendron amurense is good at clearing heat and promoting diuresis, purging fire and detoxifying for external use, and can dispel dampness and heal sores. Their combination has the effects of clearing away heat and purging fire, detoxicating and detumescence, eliminating dampness and healing sores, and relieving pain and itching. It can be used for treating oral erosion, ulcer, sore mouth and tongue, sore throat and other symptoms caused by excessive internal heat.
Borneolum Syntheticum and Rhizoma Arisaematis: Borneolum Syntheticum tastes bitter, cool, clear away heat and relieve pain. Good at resuscitation, purging fire, removing turbidity, improving eyesight, clearing away heat, reducing swelling and relieving pain; Rhizoma arisaematis has bitter taste, warm nature, dryness and dampness, phlegm-resolving, wind-dispelling, convulsion-relieving, swelling-reducing and mass-resolving. It is a specific medicine for dispelling wind and resolving phlegm. The combination of the two is especially suitable for coma and jaw closure caused by heat entering pericardium, stroke, phlegm syncope or convulsion.
pharmacokinetics
Borneol is easily absorbed by mucous membrane and subcutaneous tissue, and is excreted after combining with glucuronic acid in vivo. 3H- Borneol 1μCi/(g body weight) can be rapidly absorbed by the intestinal mucosa of mice, and it can penetrate the blood-brain barrier after 5 minutes, and its concentration in the central nervous system is high and its retention time is long, which may be related to its resuscitation. Borneol can maintain a high blood drug concentration in the blood for a long time, and it is quickly eliminated by liver and kidney and is not easy to accumulate. The half-life of 3H- borneol 2.6μCi/ mouse is 2.8min, which is mainly distributed in heart, lung, liver and kidney. 3.5μCi/ gavage, half-life of 0. 1.57 hours, absorption coefficient of 0.25, indicating poor bioavailability; The elimination half-life is 5.3 hours, and it is not easy to accumulate.
Pharmacology (toxicology)
The experimental results of acute toxicity of borneol are different. The LD50, L-borneol, D-borneol and dl- isoborneol of mice were 3720mg/kg, 4960mg/kg and 3830mg/kg, respectively. Borneol, isoborneol and synthetic borneol were 2879 mg/kg, 2269 mg/kg and 2507 mg/kg respectively. It is also reported that borneol is 1059mg/kg. The LD50 of borneol emulsion was 907mg/kg after intraperitoneal injection in mice. Chronic administration of 125mg/kg and 500mg/kg, 1- borneol and dextroborneol have effects on peripheral blood indexes and organ weight; Liver damage caused by dl- isoborneol. The Michaelis constant (Km) of alkaline phosphatase in synaptosomes of rats was increased by oral administration of 5g/kg(=LD50) borneol, which indicated that borneol had competitive inhibitory effect on alkaline phosphatase, which may be related to its neurotoxicity.
The two are different things. The specific price can be asked in the sales department or wholesale department of traditional Chinese medicine.
Online price of moxa powder 120 yuan/kg, borneol 58 yuan/kg.