Levofloxacin is widely used in clinic, and infusion is also often used. The application of levofloxacin does not require a skin test, but not requiring a skin test does not mean that it will not be allergic. Clinically, it may still cause allergic shock. For other side effects, please refer to the instructions:

Pharmacology and toxicology

This product is levorotatory of ofloxacin, and its antibacterial activity is about twice that of ofloxacin. Its main mechanism is to inhibit the activity of bacterial DNA gyrase (bacterial topoisomerase II) and hinder bacterial DNA replication. This product has the characteristics of broad antibacterial spectrum and strong antibacterial effect. It has strong antibacterial activity against most Enterobacteriaceae bacteria, such as Escherichia coli, Klebsiella, Serratia, Proteus, Shigella, Salmonella, Citrobacter, Acinetobacter, Pseudomonas aeruginosa, Haemophilus influenzae, Neisseria gonorrhoeae and other gram-negative bacteria. It also has good antibacterial effect on some methicillin-sensitive staphylococcus, streptococcus pneumoniae, streptococcus pyogenes, streptococcus hemolyticus and other gram-positive bacteria and Legionella, mycoplasma and chlamydia, but it has poor antibacterial effect on anaerobic bacteria and enterococci.

indication

This product is suitable for the following mild and moderate infections caused by sensitive bacteria; Respiratory infection: acute bronchitis, acute attack of chronic bronchitis, diffuse bronchiolitis, bronchiectasis complicated with infection, pneumonia, tonsillitis (abscess around tonsils); Urinary system infection: pyelonephritis, complicated urinary tract infection, etc. Reproductive system infection: acute prostatitis, acute epididymitis, intrauterine infection, adnexitis of uterus, pelvic inflammatory disease (metronidazole can be used when anaerobic infection is suspected); Skin and soft tissue infection: infectious pustulosis, cellulitis, lymphangitis, subcutaneous abscess, perianal abscess, etc. Intestinal infection: bacillary dysentery, infectious enteritis, salmonella enteritis, typhoid fever and paratyphoid fever; Various infections in patients with sepsis, granulocytopenia and hypoimmunity; Other infections: mastitis, trauma, burn and postoperative wound infection, abdominal infection (metronidazole if necessary), cholecystitis, cholangitis, bone and joint infection, and ENT infection.

adverse effect

Symptoms such as nausea, vomiting, abdominal discomfort, diarrhea, loss of appetite, abdominal pain, abdominal distension, nervous system symptoms such as insomnia, dizziness, headache, rash, itching and so on may occur during the medication. Transient liver dysfunction may also occur, such as increased serum transaminase and serum total bilirubin. The incidence of these adverse reactions is between 0.1~ 5%. Occasionally, blood urea nitrogen rises, fatigue, fever, palpitation, abnormal taste, etc., which can generally be tolerated and quickly disappear after the course of treatment.

matters need attention

1.The dosage interval should be reduced or prolonged in patients with renal insufficiency, and should be used with caution in patients with severe renal insufficiency. 2. Patients with a history of central nervous system diseases and epilepsy should use it with caution. 3. Quinolones can cause rare phototoxic reactions (incidence < 0.1%). Excessive sun exposure and artificial ultraviolet rays should be avoided when receiving this product. Stop using this product in case of photosensitive reaction or skin damage. 4. In case of allergy, stop taking medicine immediately, and take the following drugs or methods for treatment according to the specific clinical conditions; Adrenaline and other rescue measures, including oxygen inhalation, intravenous infusion, antihistamines, corticosteroids, etc. 5. In addition, there are occasional reports of calcaneal inflammation or calcaneal fracture after taking the medicine, so if the above symptoms occur, stop taking the medicine immediately and rest, and do not exercise until the symptoms disappear. 6. If taking too much, the contents of the patient's stomach should be removed, proper rehydration should be maintained, and clinical observation should be made. 7. Levofloxacin cannot be effectively eliminated by hemodialysis or peritoneal dialysis. 8. Drug interaction: When this product is used together with magnesium or aluminum-containing antacids, sucralfate, metal cations (such as iron), zinc-containing multivitamin preparations and other drugs, it will interfere with the absorption of this product in the gastrointestinal tract, so that the concentration of this drug in each system will be significantly reduced. Therefore, the time of taking the above drugs should be at least 2 hours before or after using this product. Avoid using theophylline at the same time. If simultaneous application is needed, the plasma concentration of theophylline should be monitored to adjust the dose accordingly. When warfarin or its derivatives are used simultaneously, prothrombin time or other coagulation tests should be monitored. Combined with non-steroidal anti-inflammatory drugs, it may cause convulsions. When used together with oral hypoglycemic drugs, it may cause blood sugar disorders, including hyperglycemia and hypoglycemia. Therefore, attention should be paid to monitoring blood sugar concentration during medication, and once hypoglycemia occurs, this product should be stopped immediately and treated appropriately.

Contraindications: people who are allergic to quinolones, pregnant and lactating women, and patients under 18 years old are prohibited.