Chen Liji Shujin Jianyao Pill is a traditional Chinese medicine preparation based on the 400-year-old experience. It specializes in treating lumbar disc herniation and sciatica, spinal canal stenosis, lumbar hyperosteogeny, lumbar muscle strain, etc. It involves many aspects of modern medicine, such as skeletal system, nervous system, immune system and muscle system. Through the research on gene chip of Shujin Jianyao Pill and its application in the treatment of clinical symptoms related to lumbar process, it is shown that Shujin Jianyao Pill has the functions of relaxing muscles and tendons, dredging collaterals, promoting blood circulation, nourishing blood, promoting qi circulation, removing blood stasis and promoting marrow production. Researchers in Chen Liji Pharmaceutical Factory studied Shujin Jianyao Pill, a mature and stable Chinese patent medicine, by applying the latest gene chip technology in molecular biology, and analyzed the main pharmacological effects and mechanism of Chinese patent medicine through the application of new technology, which promoted the modernization of basic theory of Chinese patent medicine and opened up a new world on the road of modernization research of Chinese traditional medicine compound.