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From the point of view of metabolism of methadone hydrochloride in vivo, the reasons for its long analgesic effect were explained.

methadone hydrochloride is metabolized to generate methadone, and the analgesic activity of methadone is

weaker than that of the original drug, and then it is metabolized to get demethylmethadone and demethylmethadone, which has a longer half-life than methadone, so methadone has a longer analgesic effect.