Granuloma of the lymph nodes in guinea pigs is caused by a variety of reasons, including infectious and non-infectious diseases. Symptoms include enlarged lymph nodes, pain, fever, and weight loss, etc. Preventive methods include maintaining clean and sanitary living environments, regular medical checkups and immunizations, and avoiding contact with pathogen-carrying animals and people. There are several causes of lymph node granuloma in guinea pigs, and infection is one of the most common. A number of bacterial, fungal, and parasitic infections lead to lymph node granulomas in guinea pigs. Some autoimmune and allergic diseases also cause lymph node granulomas. Symptoms of lymph node granulomas in guinea pigs include enlarged lymph nodes, pain, fever, and weight loss.