Because the body has metabolic functions, a small amount of practical cottonseed oil is not harmful. It cannot be applied in large quantities.

The seed oil contains gossypol, which is a relatively harmful substance. Long-term consumption of large amounts can cause significant damage to the liver, intestinal tract and nervous system, and in severe cases can cause infertility. Gossypol has a strong spermicidal effect, which will affect the survival of sperm, cause testicular atrophy in men, and cause infertility and dead sperm. It can also cause hypokalemia, fatigue and heart rhythm. Abnormality etc.