As far as possible to remove all the factors that may lead to leukopenia and granulocytopenia; treatment of the primary disease, such as hyper-splenism patients can be considered to cut the card.

2. Long-term follow-up

Treatment is usually not needed if the blood picture is stable and no infection occurs.

3. Antibiotic usage

The main manifestation of neutropenia is infection, but the risk of infection occurrence is negatively correlated with the degree of neutropenia. Attention should be paid to maintaining hygiene of the mouth, gums, and skin in order to minimize recurrent infections, but prophylactic use of antibiotics is generally not advocated. If infection occurs, empiric broad-spectrum antibiotic therapy should be given immediately after pathogenetic examination, and antibiotics should be adjusted according to the results of pathogenetic examination and drug sensitivity tests.

4. Colony-stimulating factor

It is the most certain granulocyte-boosting drug, mainly granulocyte colony-stimulating factor (G-CSF) and granulocyte/macrophage colony-stimulating factor (GM-CSF).

5. Other drugs to stimulate leukocyte growth

There are many types of drugs in this category, including vitamin B4, B6, lisinopril, aminopeptide, shark liver alcohol, inosine (all in regular dosage), and lithium carbonate, etc., but all lack of certainty and long-lasting efficacy.

6. Immunosuppressive agents

Confirmed diagnosis of immune granulocytopenia or cytotoxic T-cell-mediated bone marrow failure patients, can be used glucocorticoids, azathioprine, cyclophosphamide, high-dose gammaglobulin and so on.

7. Granulocyte infusion

Generally do not need to do prophylactic infusion, can be applied when the following three conditions coexist: granulocyte deficiency (<0.5 × 10 / L); accompanied by serious infections; high-level antibiotic treatment is ineffective for 48 hours.

8. Hematopoietic stem cell transplantation

Because of the high mortality rate associated with the treatment of allogeneic hematopoietic stem cell transplantation, the advantages and disadvantages should be weighed, and the indications should be mastered, and only be considered as an option for those who have serious conditions.