Toxic and side effects of Panax notoginseng saponins

Notoginseng saponins can inhibit platelet aggregation and increase cerebral blood flow, and are used for cerebrovascular sequelae, central retinal vein occlusion, anterior chamber hemorrhage, etc. So do you know the toxic and side effects of notoginseng saponins? ?The following is the relevant content about the toxic and side effects of notoginseng saponins that I have compiled for you. I hope it will be useful to you!

The toxic and side effects of notoginseng saponins

Occasionally allergic rashes, stomach Intestinal discomfort or a small amount of bleeding, such as gum bleeding, blood in sputum, increased menstrual flow in women, and occasional increase in blood pressure in practical applications are more common in the elderly.

Pharmacological effects of Panax notoginseng saponins

Modern pharmacological research shows that total Panax notoginseng saponins are the main active ingredients of Panax notoginseng. Total notoginseng saponins have the following pharmacological and functional effects:

Effects on hyperlipidemia

Using total notoginseng saponins to achieve lipid-lowering and antithrombotic effects in patients with hyperlipidemia clinical research. Results: After treatment, there were obvious anti-platelet aggregation and fiber-reducing effects, and the clinical efficacy and improvements in blood lipids and blood rheology were better than those in the control group. Research shows that total saponins of Panax notoginseng have obvious preventive and therapeutic effects on hyperlipidemia.

Effect on hyperviscosity

Patients with hyperviscosity were divided into Panax notoginseng total saponins group and enteric-coated aspirin group. After a course of treatment for 4 weeks, The results showed that total saponins of Panax notoginseng can significantly reduce platelet surface activity, inhibit platelet adhesion and aggregation, anti-thrombosis, and improve microcirculation, and are better than aspirin.

Effect on hypertension

Using Panax notoginseng saponins to treat hypertension, after 20 days of treatment, it can significantly reduce the elevated blood pressure and significantly slow down the heart rate. The results show that Panax notoginseng total saponins can significantly reduce the elevated blood pressure and significantly slow down the heart rate. The results show that Panax notoginseng total saponins can Saponins can significantly reduce MDA, significantly increase SOD, increase red blood cell deformability, and reduce red blood cell aggregation in patients with hypertension.

Anti-myocardial ischemia effect

Observation of the effect of total notoginseng saponins on experimental myocardial ischemia found that total notoginseng saponins can significantly improve the ischemic manifestations of surface electrocardiogram and shrink the myocardium. The extent of the infarction can reverse the left ventricular diastolic dysfunction in patients with exertional angina and even return it to normal.

Anti-arrhythmic

To observe the anti-arrhythmic effect of Panax notoginseng saponins, animal experiments show that Panax notoginseng saponins can significantly reduce experimental ventricular premature beats in rats. The duration of arrhythmia is significantly shortened, and the incidence of arrhythmia during reperfusion after acute myocardial infarction in rats is significantly reduced.

Anti-atherosclerotic effect

Observing the effect of total notoginseng saponins on feed-induced atherosclerosis in rabbits shows that total notoginseng saponins can have anti-inflammatory and antioxidant effects. , exerts an anti-AS effect, has a protective effect on vascular smooth muscle cells, can protect cells from the influence of high-fat serum, and has a certain preventive and therapeutic effect on the occurrence and development of atherosclerosis.

Anti-thrombosis and improvement of microcirculation

Study on the effect of total notoginseng saponins on ET-1 and platelet function in patients with coronary heart disease. The results showed that total notoginseng saponins can significantly reduce platelet function. Surfactant, inhibiting platelet aggregation and adhesion, anti-thrombosis, improving microcirculation, etc.

Anti-cardio-cerebral ischemia effect

Panax notoginseng total saponins are used to treat cerebral infarction and ischemic cerebrovascular disease. The results show that notoginseng total saponins have a better effect on the acute phase of cerebral infarction. The clinical therapeutic effect of Panax notoginseng saponins can significantly improve cerebral edema during global cerebral ischemia or focal ischemia-reperfusion.

Promote the growth of hematopoietic cells

Total notoginseng saponins have a proliferation effect on hematopoietic progenitor cells. Research has also found that Rg1 and Rb1 in total notoginseng saponins are effective monomers in promoting hematopoiesis. It can continuously promote the proliferation of human bone marrow granulocyte and erythroid hematopoietic progenitor cells, and has a better effect on granuloid progenitor cells than erythroid progenitor cells.

Anti-fibrosis

Studies at the cellular level have found that Panax notoginseng saponins can delay the process of renal tubule-interstitial fibrosis and improve renal function. Experiments have found that total saponins of Panax notoginseng can delay the onset of alveolitis, make it progress slowly, be mild, and almost not form pulmonary fibrosis.

The effect of Panax notoginseng total saponins on experimental liver fibrosis was studied through animal experiments. The results showed that notoginseng saponins had significant anti-hepatic fibrosis effects.

Protective effect on nerve cell damage

The protective effect of Panax notoginseng total saponins on model cells was observed through the detection of cytology, morphology and lipid peroxidation damage indicators. The results showed that Panax notoginseng saponins have a protective effect on nerve cell damage caused by energy metabolism disorders

Medicinal applications of Panax notoginseng saponins

This product is a light yellow amorphous powder with a bitter taste and a slightly sweet taste. .

Panax total saponins are effective medicinal ingredients extracted from high-quality Panax notoginseng based on extraction and separation technology, including more than 20 saponin active substances, 17 trace elements, proteins, rich vitamins, polysaccharides, etc.< /p>

Panax notoginseng saponins are currently mainly used in medicines and health care products for cardiovascular and cerebrovascular diseases, such as Xuesaitong and Compound Danshen Dropping Pills.