The skin color of the first vulva is mostly purplish red or reddish, and it can also be grayish white or grayish blue, mixed with well-defined white keratinized plaques with different shapes and sizes. Mixed malnutrition has mixed symptoms of atrophy and hyperplasia. The clinical manifestations of leukoplakia vulvae include obvious atrophy of vulva, hypertrophy of clitoris prepuce, obvious keratinization, coarse lines of labia majora, hypopigmentation, localized thickening ulcer and so on. The affected skin is rough, mossy, scratched and sometimes chapped. Local hypopigmentation, labia majora and labia minora generally turned white. The patient's vulva can be slightly atrophied. In severe cases, clitoris, labia majora, labia majora atrophy and adhesion, and labia minora partially or completely disappear. After that, the vaginal opening narrows, the elasticity disappears, and even affects urination and sexual life. Systemic disease factors, such as diabetes, jaundice, autoimmune diseases and metabolic dysfunction diseases. This is one of the symptoms of vulvar leukoplakia.

Secondly, vulvar pruritus is the most prominent symptom of vulvar leukoplakia, especially at night. The degree of itching is related to time, menstruation, climate, food, environment and mood. Itching is generally intermittent, and patients often scratch around because of strange itching. Due to scratching, the external vagina has many scratches and redness, which is the result of long-term itching, causing local collapse, chapping, ulceration and secondary infection. Therefore, patients often have local burning sensation, especially clitoris and labia minora, which are very sensitive. The symptoms of vulvar leukoplakia are early hyperkeratosis and fatty skin infiltration. There are localized or diffuse white thickening, leather-like swelling, wrinkles, scales and eczema-like changes in vulva skin and mucosa.