First, the most common side effects are headache and edema. Peripheral edema is the most common adverse event.

Second, the incidence of the following side effects in patients ranged from 0. 1% to 1%:

Cardiovascular system: arrhythmia (including ventricular tachycardia and atrial fibrillation), bradycardia, chest pain, hypotension, peripheral ischemia, syncope, tachycardia, postural dizziness, postural hypotension and vasculitis.

2, central and peripheral nervous system: insensitive, peripheral neuropathy, abnormal sensation, tremor, dizziness.

3, gastrointestinal system: loss of appetite, constipation, indigestion, dysphagia, diarrhea, flatulence, pancreatitis, vomiting, gingival hyperplasia.

4. General body: allergic reaction, fatigue, backache, hot flashes, general malaise, pain, rigidity, weight gain and weight loss.

5, musculoskeletal system: joint pain, joint disease, muscle spasm, myalgia.

6. Psychiatry: sexual dysfunction (male and female), insomnia, nervousness, depression, abnormal dreams, anxiety and personality disorder.

7, respiratory system: dyspnea, nosebleed.

8. Skin and appendages; Vascular edema, erythema multiforme, itching, rash, erythema, maculopapular rash.

Third, the incidence of these side reactions is 1% to 2%.

Abnormal sensation: abnormal vision, conjunctivitis, diplopia, eye pain, tinnitus.

Urinary system: frequent micturition, dysuria and nocturia.

Autonomic nervous system: dry mouth and sweating.

Nutritional metabolism: hyperglycemia, thirst.

Hematopoietic system: leukopenia, purpura, thrombocytopenia.

4. The incidence of the following side effects is less than 0. 1%: heart failure, arrhythmia, premature beats, skin discoloration, urticaria, dry skin, dermatitis, myasthenia, convulsion, dystonia, migraine, cold skin, apathy, excitement, forgetfulness, gastritis, increased appetite, loose stool and cough.