Chronic glomerulonephritis should be treated accordingly for the type of renal biopsy pathology. Such as inhibiting immune-mediated inflammation, inhibiting cell proliferation, reducing renal sclerosis, and should prevent or delay progressive deterioration of renal function, improve or alleviate clinical symptoms, as well as prevention and treatment of comorbidities as the main purpose. The main principles of treatment include the following: actively controlling hypertension, preventing renal decompensation, and preventing cardiovascular comorbidities. To improve the long-term prognosis, according to the patient's specific situation, choose ACEI or ARB a class of antihypertensive drugs that have the effect of reducing urinary protein, control protein intake, avoid infection, dehydration, fatigue, taking nephrotoxic drugs, such as aminoglycoside antibiotics, non-steroidal anti-inflammatory drugs, contrast media, and other factors aggravating renal damage, a variety of treatments need to be carried out under the guidance of a specialized doctor.