1, the curative effect is not clear, according to some theories and practices of traditional Chinese medicine, several kinds of medicinal materials can play different roles from the simple formula of granules, such as Shengmai powder (ginseng, Ophiopogon japonicus). The curative effect of decoction with Schisandra chinensis is significantly stronger than that of granules mixed with the above three kinds of granules; In Sini Decoction (Radix Aconiti Lateralis Preparata, Rhizoma Zingiberis Preparata, Radix Glycyrrhizae Preparata), decocting the decoction together not only has a significantly stronger curative effect than the granular formula of mixing them, but also greatly reduces the toxicity of aconitine contained in Radix Aconiti Lateralis. It is found that this is because several kinds of medicinal materials are decocted together, during which a series of chemical changes such as combination, complexation, dissolution and so on have taken place in their effective components, reaching the curative effect considered by traditional Chinese medicine theory, while the granular formula has no or few of these reactions, which greatly reduces the curative effect, which has been reflected in many formulas.

2. There are phenomena such as inferior quality in preparation manufacturers. The National Pharmacopoeia requires the effective components of medicinal materials, but simple component analysis is sometimes inconsistent with practice. For example, the effective components of leaves and whiskers of ginseng are much higher than roots, but the practical curative effect is obviously much stronger than leaves and whiskers, so manufacturers can take leaves instead of roots as raw materials of preparations, saving costs, while the efficacy is obviously not as good as decoction, but the inspection is qualified.

Therefore, the research of granule formula needs to do more work instead of rushing to the market.