Disadvantage #1: Because skewers are hybrids, their future looks and size will be uncontrollable. Disadvantage two: is that different strings will have different diseases, the following is a few strings will produce the more typical diseases. Genetic mutations can cause diseases, lower eyelids droop and turn outward causing paralytic ectropion, eyelid ectropion can lead to long-term eye infections and inflammation, and overgrown ears can lead to bacterial infections in the ear canal.