1, immunomodulation: significantly enhance the functions of mononuclear phagocytes and natural killer cells, promote the proliferation of splenic lymphocytes induced by concanavalin A(ConA) or phytohemagglutinin (PHA), promote the secretion of interleukin -2 and interferon-γ, promote the production of IgM antibodies, and antagonize the immunosuppressive response of adrenocortical hormones.
2. Anti-tumor effect: It can inhibit the proliferation of various transplanted tumors, such as S- 180 sarcoma, liver cancer, reticular sarcoma, non-small cell lung cancer (LA795), lymphoma and breast cancer (MCF7). Ganoderma lucidum spore powder can also significantly enhance the anti-tumor effect of cyclophosphamide and reduce its toxicity to immune system, blood and liver. In addition, it also has radiation protection effect and prolongs the average survival time of mice irradiated by cobalt 60 rays.
3. Liver protection: It has a significant protective effect on liver injury caused by D- galactosamine and carbon tetrachloride, and can reduce the elevated alanine aminotransferase and aspartate aminotransferase to near normal levels, which has a certain anti-hepatic fibrosis effect.
4. Reduce blood sugar, blood lipid and blood pressure:
A. Ganoderma lucidum spore powder can reduce the increase of diabetic blood sugar caused by alloxan and improve diabetic glucose tolerance, but it does not reduce normal blood sugar. Ganoderma lucidum spore powder can also prevent mitochondrial damage and prevent or reduce complications by regulating calcium homeostasis of diabetic epididymal cells.
B. Ganoderma lucidum spore powder can significantly reduce serum total cholesterol and triacylglycerol, increase coronary artery flow, increase the activities of lactate dehydrogenase (LDH) and creatine kinase (CK) in coronary artery perfusion fluid, significantly reduce malondialdehyde (MDA) and increase the activity of superoxide dismutase (SOD), which has a certain cardioprotective effect.
C Ganoderma lucidum spore powder can significantly reduce systolic blood pressure, diastolic blood pressure and myocardial hypertrophy index of spontaneous hypertension, and increase the expression of carnitine palmitoyl transferase 1(CPT- 1)mRNA.
5, sedative and hypnotic effect: Ganoderma lucidum spore powder has a good sedative and hypnotic effect, significantly prolonging sleep time and obviously improving learning and memory ability.
6. Anti-asthmatic effect: Ganoderma lucidum spore powder can prolong the latent period of asthma, reduce airway resistance, alleviate inflammatory lesions of lung tissue and inhibit mast cells from releasing tryptase. In the lipopolysaccharide-induced injury model of human bronchial epithelial cells, Ganoderma lucidum spore powder can obviously improve the vitality of human bronchial epithelial cells, reduce the concentrations of MDA, TNF-α and IL-6 in cell supernatant, increase the content of SOD and reduce the expression of NF-κB protein in cells.
7. Protective effect on kidney: Ganoderma lucidum spore powder can obviously improve renal function and renal lesions caused by chemotherapy drug adriamycin, and increase serum protein. After taking the medicine, the degree of glomerular sclerosis and mesangial proliferation rate decreased significantly.
Source: Ganoderma Zongtan