Osteosarcoma as long as the symptoms are manifested as localized pain, mostly persistent, gradually aggravated, especially at night, accompanied by systemic malignancy, limited movement of nearby joints, localized elevated skin temperature, venous rage, easy to lead to pathological fractures. Vascular tremor can be felt or vascular murmur can be heard. radiographs show a combination of new bone formation and osteolytic destruction.
The treatment of osteosarcoma emphasizes early comprehensive treatment, mainly surgery and chemotherapy. If the diagnosis is clear and there is no lung metastasis, high amputation or arthrodesis should be performed, followed by chemotherapy. If there is a single source of lung metastasis, amputation and resection of lung metastasis can be performed at the same time. Radiation therapy is not sensitive to osteosarcoma and is only used as an adjuvant treatment before or after surgery, or when the tumor cannot be resected or when there are lung metastases.
About the treatment: 1. Osteosarcoma is mainly treated with comprehensive therapy, including surgery, chemotherapy and radiotherapy. 2. Since the 70s, high-dose chemotherapy has been prevalent, which is used in preoperative and postoperative period, so that the cure rate of osteosarcoma is greatly improved, and the five-year survival rate can be more than 50%. 3. Chemotherapy is commonly used in the following cases: (1) as an adjuvant therapy for surgery; (2) certain parts of the body cannot be operated radically; (3) as a palliative therapy for advanced stages; (4) patients refuse surgery. The commonly used chemotherapeutic drugs advocate the combination of more than two kinds of drugs, and pay attention to ensure that the amount of urine and alkalinization of the urine, in order to reduce the toxicity of the renal response.
Evaluation of therapeutic effect 1. Cure: After surgery and chemotherapy, no tumor survives for more than two years. 2. Nearly cured: after chemotherapy and amputation, no lung or other metastases have been found recently. 3. Improvement: the tumor shrinks significantly after chemotherapy and the symptoms are reduced.
The principle of treatment is still based on surgery and chemotherapy. However, the prognosis is poor.
The limb-sparing treatment of osteosarcoma is still difficult! High-dose chemotherapy can be tried, and the effect is not as good as "chemotherapy-surgery-re-chemotherapy" comprehensive treatment program, and if there is metastatic foci, surgical resection is also possible.
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