You can get Creutzfeldt-Jakob disease. Creutzfeldt-Jakob disease is a rare transmissible encephalopathy that occurs primarily between the ages of 50 and 70. Infected individuals can have symptoms such as sleep disturbances, personality changes, ****typhosis, aphasia, loss of vision, physical, muscular atrophy, myoclonus, and progressive dementia, and can die within a year of the onset of the disease. The disease often has a chromosomal familial predisposition, and a new case of Creutzfeldt-Jakob disease (which is potentially linked to bovine spongiform encephalopathy) has been reported. Pathologic features of the disease include spongiform degeneration predominantly in the cerebellum and cerebral cortex and the presence of prions. People who consume beef and bovine spinal cord contaminated with BSE are at risk of contracting the fatal Creutzfeldt-Jakob disease. Patients first show agitation and eventually die of insanity.

The current international understanding of Creutzfeldt-Jakob disease and variant Creutzfeldt-Jakob disease is that infectious prions, mutants of PrP, a normal protein on the surface of nerve cells, also known as Puri prions or protein-infesting factors, can remain quiescent for up to 15 years after entering the human brain, but once prions have been stimulated, the disease can flare up and cause death in as little as 12 to 18 months. 18 months. Symptoms include depression, coordination problems, memory loss, mood swings, pins and needles in the limbs, severe headaches, severe colds, sore feet, redness of the skin, and transient memory loss. The majority of the fewer than 200 cases of variant Creutzfeldt-Jakob disease found worldwide have been in young adults (average age of death is 28 years). Prion-induced diseases are found in a wide variety of mammals, ranging from "mad cow disease" in cattle, to itchy sheep disease in sheep, to chronic atrophic disease in deer. The effects of these diseases on the structure of the brain tissue are fatal and incurable. The prognosis is extremely poor, and all cases invariably die

.