Pig spleen, also called Liantie, called conjoined (homophonic), can be bought. It is used for cleaning and has medicinal value.

pharmacological action

1. Immunomodulatory effect Pig spleen can be used to prepare transfer factor (TF), which is a low molecular weight peptide-abscisic acid complex and one of the important lymphatic factor for mediating cellular immunity. It can specifically transfer the cellular immunity of the donor to the recipient, so that the recipient has the cellular immunity of the donor. TF can enhance the stimulation of PHA and ConA on lymphocytes, NK cells, K cells and Mφ in vitro, increase the lymphocyte transformation rate and E rosette formation rate, and promote the chemotaxis of neutrophils and monocytes. Delayed hypersensitivity (DTH) can spread or transfer in the body. TF can also trigger lymphocytes and Mφ to release IFN, TNF and ILI, and stimulate B cells to produce antibodies. Such as pig brand TF 1mg/kg, 2mg/kg and usage 4mg/kg orally, or 0.5mg/kg, 1mg/kg, 2mg/kg intraperitoneally,/kloc-0 every other day, 7 times in a row, for chemotherapy (cyclophosphamide) or tumor-bearing (s/. Oral administration of hepatitis B-specific porcine spleen TF to mice can also induce DTH of hepatitis B vaccine in experimental mice, indicating that it can transmit antigen-dependent specific effects. After incubation with human umbilical cord blood T lymphocytes, pig brand TF can activate the formation of E rosette, and its activation rate is 42.27%. Leukocyte adhesion inhibition test confirmed that TB-specific porcine spleen TF can transfer cellular immune function to tuberculosis, prolong the survival time of infected animals, reduce the mortality rate, obviously reduce the organ lesions and the number of quantitative bacterial cultures of infected animals, and has a protective effect on infected animals. Specific porcine TF can obviously relieve the disease, increase the overdue rate, shorten the time of hypotension and enhance the function of cell rabbit epidemic in the treatment of patients with early epidemic hemorrhagic fever. Pig brand RNA, used in mice with severe radiation injury caused by D-ray irradiation, can improve thymus index, spleen index, white blood cell count and E- rosette rate, and spleen lymph node hyperplasia is also obvious, indicating that it can enhance the immune function of the body. Porcine spleen RNA can also significantly improve the formation rate of E- rosette when used to treat small respiratory tract infection, but there is no significant difference in immunoglobulin and complement C3 compared with the control group. Immunoribonucleic acid (I-RNA) can also increase the number of rosette-forming cells in nude mice and mice whose thymus was excised after birth. It can also effectively treat human viral myocarditis and protect animals from the deadly infection of plasmodium. 2. Anti-tumor effect Both I-RNA and TF can sensitize and mediate the cytotoxic effect of lymphocytes on tumor cells. In vitro, I-RNA makes non-sensitized lymphocytes become effector cells, and produces immune response to corresponding tumor cells. In vivo, non-sensitized animals can obtain immune information and inhibit or destroy tumor growth. Specific transfer factor (S-TF) significantly inhibited the incorporation of [3H]UR into gastric cancer cells, while I-RNA and S-TF also inhibited the malignant transformation of tumors and the expression of oncogenes. Their combination can synergistically inhibit RNA synthesis of tumor cells. Both TF and S-TF of S 180 cells can inhibit the DNA synthesis of S 180 cells and obviously inhibit the growth of S 180 metastatic tumors. Porcine spleen RNA also significantly inhibited S 180 in mice, and its inhibition rate was 36.7%-47%. 3. Immunosuppressive effect Pig brand lymphocyte suppressor (LIF) has a concentration-dependent inhibitory effect on the transformation of human peripheral blood lymphocytes (PBL) induced by phytohemagglutinin (PHA) at the concentrations of 5ug/ml, 50μg/ml and 100μg/ml, in which the effective components are polypeptides and trace nucleic acids. The immunosuppressive extract from pig spleen (SISE) has a significant inhibitory effect on the transformation of human PBL, among which SISE-j ultrafiltration component has the strongest immunosuppressive activity, especially SU3 with a relative molecular weight of 6000- 10000 and Su3 with a relative molecular weight less than 6000. Further research confirmed that SU3 had obvious inhibitory effect on the spontaneous proliferation of thymocytes and lymphocytes in mice, and had strong inhibitory effect on the transformation of spleen lymphocytes in mice induced by PHA and bacterial lipopolysaccharide (LPS), with obvious inhibitory effect at the concentration of 50μg/ml. In addition, SU3 also significantly inhibited the DTH reaction in mice, which was similar to dexamethasone at the experimental concentration. At low dose (0. 1mg/d), SU3 significantly promoted the production of SRBC antibody in mouse B cells, while at high dose (0.5mg/d and 1mg/d), it showed a strong inhibitory effect. Experiments show that SU3 can inhibit cellular immunity and humoral immunity, which is similar to similar substances from Niupai. When SISE and porcine thymus immunosuppressive extract (TISE) were compared, it was proved that both of them were nucleic acid-binding peptides, which had similar inhibitory effects on PHA-induced human PBL transformation, incorporation of 3H-TdR into mouse thymocytes and spleen cells, activation of mouse spleen cells to produce IL-2, mouse DTH reaction and production of SRBC-specific antibodies. 4. Pig brand hydrolysate prepared by proteolysis of other functional pig spleen, combined with tumor chemotherapy, can not only reduce and prevent leukopenia, but also improve platelets. Hemoglobin and red blood cells also have a certain curative effect and have a certain protective effect on bone marrow. The hydrolysate of pig spleen contains short peptides, amino acids, nucleic acid degradation products, vitamin B 12, choline and folic acid. These components can participate in and influence the metabolism of nucleic acid and protein in vivo, stimulate hematopoietic function, protect the liver, and have certain nourishing and strengthening effects. 5. Toxic pig spleen TF toxicity test proved that it had no obvious effect on blood pressure and electrocardiogram of cats, and the antihypertensive substance test met the requirements of Pharmacopoeia, and had no obvious effect on heart rate and rhythm, and had no mutagenic and teratogenic effects. The acute and subacute toxicity tests of porcine spleen RNA showed that it was non-toxic. There was no obvious cytotoxicity between SU3 component of SISE from pig spleen and mouse spleen cell culture 13h or 48h.