There is currently no cure for primary gout, but controlling hyperuricemia can reverse the condition.
First, the general treatment is to limit the intake of protein, avoid eating high-purine foods, strictly abstain from alcohol, avoid triggering factors, drink more water, and keep the urine output within two days. More than 1,000 ml per day.
Second, the treatment of acute arthritis requires absolute bed rest, elevating the affected limb, and avoiding weight-bearing on the affected joint. It should not be until about 72 hours after the joint pain is relieved that activities can be gradually resumed. And the following drugs should be applied as soon as possible to control arthritis and relieve symptoms.
Including colchicine, which has significant efficacy in controlling gouty arthritis and should be the first choice. Nonsteroidal anti-inflammatory analgesics are more suitable for patients who cannot tolerate colchicine. The main drugs include ibuprofen and corticosteroids.
It is mainly aimed at quickly relieving the onset of acute arthritis, but it is easy to relapse after stopping the drug. Long-term use can easily lead to complications such as diabetes and hypertension, so it is not suitable for long-term use.
Third, the treatment of intermittent and chronic phases mainly involves the rational use of drugs that inhibit uric acid synthesis and promote uric acid excretion to control hyperuricemia.
Part 1 , Resolutely not eat foods containing high purine, such as beer, seafood, animal offal, etc.;. Second, you can safely eat low-purine foods such as vegetables and fruits. Eggs and milk (except yogurt) have low purine content and are excellent sources of protein for people with gout, so they can be eaten with confidence;. Third, you can eat chicken, duck, fish, and meat appropriately, but do not drink soup. When eating meat, it is best to blanch it in boiling water to remove purine components. Acute stage: The patient should rest in bed and elevate the affected limb. Generally, the patient should rest until the joint pain is relieved for 72 hours before resuming activities. The earlier the drug treatment, the better. Early treatment can quickly relieve symptoms, while delayed treatment can make inflammation difficult to control. Commonly used drugs include the following:. 1. Colchicine has special effects on gout and hyperuricemia. Start with 0.5 mg per hour or 1 mg every 2 hours. Stop using colchicine when symptoms are relieved or gastrointestinal side effects such as nausea, vomiting, and diarrhea occur. Generally, it takes about 4 to 8 mg, symptoms can be relieved within 6 to 12 hours and controlled within 24 to 48 hours. From now on, 0.5 mg can be given two or three times a day for a few days and then discontinued. If the gastrointestinal reaction is too severe, 1 to 2 mg of this drug can be dissolved in 200 ml of normal saline and slowly injected intravenously within 5 to 10 minutes. However, care should be taken to prevent the drug from leaking. It can be injected again after 6 to 8 hours depending on the condition. People with renal insufficiency should not exceed 3 mg within 24 hours. Due to its excellent clinical efficacy, experimental treatment can be used for cases with difficult diagnosis, which is helpful for differential diagnosis. During colchicine treatment, attention should be paid to reactions such as leukopenia and alopecia. 2. Phenylbutazone or hydroxyphenbutazone has obvious anti-inflammatory effects and can promote the excretion of uric acid. It is still effective for those who have been ill for several days. The initial dose is 0.2 to 0.4g, and then 0.1g every 4 to 6 hours. After the symptoms improve Reduce to 0.1g 3 times a day and stop taking it for several days. This medicine can cause gastritis and water and sodium retention, so it should not be used in patients with active ulcer disease and those with cardiac insufficiency. Side effects of leukopenia and thrombocytopenia occasionally occur. 3. The initial dose of indomethacin is 25 to 50 mg, once every 8 hours. After the symptoms are relieved, take 25 mg 2 to 3 times a day. For the second and third days, the efficacy is similar to that of phenylbutazone, but side effects include gastrointestinal Tract irritation, water and sodium retention, dizziness, headache, rash, etc. It is prohibited for those with active peptic ulcer. 4. Ibuprofen (ibuprofen ibuprofen) is a non-steroidal anti-inflammatory analgesic. 0.2-0.4g 2-3 times a day can relieve acute symptoms within two or three days. Control, this drug has minor side effects, has no significant impact on hemogram and renal function, and may occasionally cause gastrointestinal reactions and elevated transaminases. 5. Piroxicanum has a long-lasting effect. Take 20 mg once a day. Occasionally, gastrointestinal reactions may occur. During long-term use, attention should be paid to blood count and liver and kidney function.
6. Naproxen (naproxen) is a non-steroidal anti-inflammatory analgesic. Its anti-inflammatory effect is 11 times that of phenylbutazone and its analgesic effect is 7 times that of aspirin. It has less gastrointestinal reaction and can be taken orally at 500-750 mg per day. , taken in two doses. 7. When the condition of ACTH and prednisone is severe and treatment such as colchicine is ineffective, 25 mg of ACTH can be added to glucose for intravenous infusion, or 40 to 80 mg can be injected intramuscularly. This drug has a rapid effect, but it is easy to cause pain after stopping the drug. If "rebound" recurs, 0.5 mg of colchicine can be added two or three times a day to prevent "rebound". Triamicinolonehexacetonide 5 to 20 mg can also be injected into the arthritis area for treatment. Oral prednisone is also quick-acting, but it is easy to relapse after stopping the drug, and long-term use of hormones can easily cause complications such as diabetes and hypertension, so it should be avoided as much as possible. Depending on the patient's condition, different methods are used in a targeted manner. It is recommended to consult a doctor specifically!