sāng bái pí
2 English referencecortex mori radicis [Langdao Chinese-English Dictionary]
mori cortex [Xiangya Medical Dictionary]
white mulberry root [Xiangya Medical Dictionary]
white mulberry root [Xiangya Medical Dictionary]
white mulberry root [Xiangya Medical Dictionary]. Dictionary]
rootbark of white mulberry [Xiangya Medical Dictionary]
white mulberry bark [Xiangya Medical Dictionary]
Cortex Mori (拉) [Nomenclature Review Committee of Chinese Medicine. Chinese Medicine Nomenclature (2004)]
white mulberry rootbark [中中醫学名词审定委员会. Nomenclature of Chinese medicine (2004)]
3 OverviewSang Bai Pi is the name of the traditional Chinese medicine, out of the "Treatise on Medicinal Properties". It is the dried root bark of Morus alba L., family Moraceae[1].
The Pharmacopoeia of the People's Republic of China (2010 edition) contains pharmacopoeial standards for this Chinese medicine.
4 Latin nameCortex Mori (拉) ("Nomenclature of Chinese Medicine (2004)")
5 English namewhite mulberry rootbark ("Nomenclature of Chinese Medicine (2004)")
6 Alias of Mulberry White PeelMulberry Root White Peel, Mulberry Root Peel, Mulberry Peel[2].
7 SourceSangbai Pi is the dried root bark of Morus alba L., family Moraceae [1].
Sang Bai Pi is the root bark of Morus alba L., family Moraceae [2].
8 OriginSangbaipi is mainly produced in Anhui, Henan, Zhejiang, Jiangsu, Hunan [2].
9 Sexual flavor attributed to the meridianSangbaipi flavor sweet, cold; into the liver, spleen meridian [2].
10 Sangbai Pi efficacy and main treatmentSangbai Pi has the effect of lung diarrhea and asthma, diuresis, lowering blood pressure [2]:
Sangbai Pi treatment of lung heat cough and asthma, edema, foot fungus, urinary incontinence, hypertension, diabetes mellitus: decoction, 6 ~ 15g [2].
Morus alba bark treatment of pediatric thrush: fresh root bark pounded juice applied [2].
The white liquid juice in the mulberry bark is called mulberry bark juice, also known as mulberry juice, mulberry wood juice, mulberry white juice, applied to pediatric mouth sores, trauma bleeding [2].
Sangbaipi is a commonly used ophthalmic water-relieving and dampness-permeating drug, which has the effects of diarrhea, asthma, diuresis, and swelling:
(1) It is used to treat gold noma and fire noma caused by the lung meridian's heat depletion, and it is often paired with Dibiao Pi, such as diarrhea and white powder.
(2) Used for white eye swelling, oedema under the eyes, etc., can be used with Poria bark and ginger bark, such as five bark drink.
11 The chemical composition of mulberry white barkThe root bark of mulberry white bark contains a variety of mulberry white bark (Moracenin), mulberry root bark (Morusin), mulberry pigment (Mulberrin), cyclopentin, mulberry chromene (Mulberrochromene), cyclopentin, mulberry flavonoids (Kuwanon) A, B, C, betulinic acid, etc. [2].
Mulberry white bark also contains a variety of mulberry flavonoids, mulberry geranylgeranyl, mulberry color furan, but also mulberry glycoprotein A, mulberry polysaccharides, etc. [2].
12 Pharmacological Actions of Morus alba PiThe decoction of Morus alba Pi has a diuretic effect on rabbits, and the extract has a significant hypotensive effect on anesthetized rabbits, and a sedative effect on mice [2].
Acidic constituents such as sangenpiin have an inhibitory effect on arachidonic acid metabolism TXB2 in platelets [2].
13 The Chinese Materia Medica: Sang Bai Pi 13.1 OriginFrom the Treatise on Medicinal Properties. This method was used by Tang An Jinzang to heal his disembowelment.
13.2 PinyinSānɡ Bái Pí
13.3 Alias of SangbaipiSanggen Bái Pi, Bái Sangpi Sangsangpi, Root Pi
13.4 SourceOrigin of the herb
Sanggen Bái Pi, Morus alba, Morus alba, Root Pi
13.5 Origin and sourceSanggen Bái Pi, Moraceae.
Latin botanical and animal mineral name: Morus alba L.
Harvesting and storage: more in the spring and fall to dig up the roots, southern parts of the winter can also be dug up, to clean the soil and roots, scrape off the yellowish-brown rough skin while fresh, longitudinal dissecting the skin with a knife, with a mallet light, so that the skin and the wood part of the separation, to remove the wood heart, dry in the sun.
13.5 Original formDeciduous shrub or small tree, 315 m high, the bark is gray-white, striped lobed; the root bark is yellow-brown or reddish-yellow, highly fibrous. Leaves alternate; petiole l2.5cm long; leaf blade ovate or broadly ovate, 520cm long, 410cm wide, apex acute or acuminate, base rounded or subcordate, margin coarsely serrate or crenate, sometimes irregularly divided, glabrous and glossy above, short hairs on veins below, hairs in the axils, basal veins 3 intertwined with fine veins into a reticulated pattern, abaxial surface more conspicuous; stipules lanceolate, early falling. Flowers unisexual, dioecious; female and male inflorescences both arranged in spikelike catkins, axillary; female inflorescences l2cm long, hairy, total pedicel 510mm long; male inflorescences 12.5cm long, pendulous, slightly covered with fine hairs; male flowers with 4 tepals and 4 stamens, with sterile pistil in the center; female flowers with 4 tepals, united at the base, stigmas 2-lobed. Achenes, mostly crowded into an ovoid or oblong aggregate, l2.5cm long, green at first, becoming fleshy, black-purple or red at maturity. Seeds small. Fl. 45, fr. 56.
13.6 HabitatEcological environment: Born in hills, slopes, villages, fields, etc., mostly cultivated.
Resource distribution: distributed throughout the country.
13.7 TraitsTrait identification The root bark is twisted rolled, grooved or plate-like, varying in length, width and narrowness, and is 14mm thick; the outer surface is white or yellowish white, relatively flat, with some residual orange-yellow or brownish-yellow scaly rough skin; the inner surface is yellowish white or grayish yellow, with fine longitudinal lines. Light, tough, fibrous, difficult to break, easy to longitudinal tearing, tearing with dust. Gas is slight, taste slightly sweet.
White color, thick skin, pliable is best.
Microscopic identification root skin cross section: phloem rays wide 26 columns of cells; scattered milk tube; fibers single scattered or bundled, non-woody or slightly wooded; thin-walled cells containing starch granules, some cells contain calcium oxalate square crystals. Older root bark in the stone cells are often linked with the crystal thick-walled cells in groups.
Physical and chemical identification (1) take the powder 0.2g, add ethanol 8ml, water bath heating for 5min, filtered. Take the filtrate Zml, add a little magnesium powder and mix, add a few drops of concentrated hydrochloric acid, the solution is cherry red, and bubbles. (Check flavonoids) (2) Take 5g of crude powder of this product,;; add benzene 20ml reflux extraction for 15min, filtered. Filtrate evaporated, residue with a small amount of chloroform dissolved in a small test tube, add glacial acetic acid 1ml, along the wall of the test tube slowly add 1ml of concentrated sulfuric acid to make two layers, the interface of the two liquids show red ring.
13.8 Chemical compositionFlavonoids: mulberry (muberrin), mulberry chromene (mulberrochromene), cyclomulberrin (cyclomulberrin), cyclic chromene (cyclo-mulberrochromene) [1], mulberry root bark (mulberry root bark) [2], mulberry root bark (mulberry root bark) [1], mulberry root bark (mulberry root bark) [2], mulberry root bark (mulberry root bark) [3], mulberry root bark (mulberry root bark) [4]. morusin) [2,3], cyclomorusin, compound (pound) A [3], oxydihydromorusin [4,5], kuwanon A, B, C [4,5], D, E, F, [6], G (i.e. albanin F moracenin B) [7], H (i.e., albanin G, moracenin A) [8], I [9, 10], K, L [11], Y, Z [[12], moracenin (moracenin) C [13], D [14], sanggenone (sanggenone) A [10, 21], B, C, D [10], E [ 10,20], F[22], G[23], H, I, J, K[24], L, M, N[25], O[26], P[27]. It also contains mulberrofuran A[15], B[16], C[l0], K, N, O[17], M[18], P[19], Q[20], umbelliferone, scopoletin[28], moran A[29] and antihypertensive effects. acetylcholine analogs [30], which have antihypertensive effects.
13.9 Pharmacological effects of Morus alba1. Diuretic and diarrheal effects Morus alba decoction 2g/kg equivalent to the amount of raw drug gavage rabbits, Morus alba aqueous extracts or n-butanol extracts of 300500mg/kg to the rats by gavage or intraperitoneal injection, all have diuretic effect. Urine volume and sodium, potassium ions and chloride excretion are increased. Aqueous extract 3g/kg gavage mice, can be discharged liquid feces, indicating that there is a diarrhea effect.
2. Effects on the cardiovascular system Sangbaipi decoction and water, ethanol, n-butanol or ether and other kinds of dissolved coal extract, by intravenous injection, duodenal administration or oral, on normal dogs, rabbits, rats or hypertensive animals, there are varying degrees of antihypertensive effect, and relatively long-lasting, and accompanied by bradycardia. Its antihypertensive effect could be inhibited by atropine or by severing the vagus nerve on both sides, but was not affected by chlorpheniramine. However, it was also reported that the antihypertensive effect was still present when the vagus nerve was cut on both sides or the spinal cord was cut at the 56th cervical vertebrae, suggesting that the extract may contain acetylcholine-like substances, and that the antihypertensive effect of the domestically produced Morus alba Bark is more powerful than that of the Japanese one, but it is also more toxic. The extract of Morus alba inhibited the isolated frog heart, and this effect was also blocked by atropine. The n-butanol extract 1mg/ml could increase the frequency and force of atrial contraction in isolated rats, and then inhibit it mildly; the aqueous extract had a mild inhibitory effect. Extracts of frog heart of the lower limbs of the vasculature performance contraction; isolated rabbit ear vasodilatation, can increase blood flow, this effect can also be blocked by atropine.
3. The effect on smooth muscle canine experiments show that n-butanol extract 50mg/kg intravenous injection can significantly increase gastrointestinal activity; while the aqueous extract does not have this effect. N-butanol extract 0.1mg/ml can relax the isolated guinea pig ileum, and can inhibit its auto-rhythmic activity. It had a mild excitatory effect on rat gastric cardia sinus strips. The extract has an excitatory effect on isolated rabbit intestine and uterus.
4. Effects on the nervous system (1). Sedative and stabilizing effects Sedative and stabilizing effects can occur when mice are injected intraperitoneally with water or n-butanol extracts of Morus alba Pi at 50mg/kg or more, with reduced spontaneous activity, decreased tactile and nociceptive responses, and dilated pupils.
(2). Anticonvulsant effect The n-butanol or aqueous extract of white bark can mildly inhibit electroshock seizures in mice, but still show extensor muscle tension. The number of deaths of experimental animals was significantly reduced compared with the control group.
(3). Analgesic effect Mouse acetic acid twisting and tail pressure experiments show that the aqueous extract has a significant analgesic effect, can improve the pain threshold, 2g/kg gavage and aspirin 0.5g/kg similar to the role of.
(4). Cooling n-butanol extract mice intraperitoneal injection has a cooling effect. However, it is ineffective when administered orally to rats.
(5.) Antibacterial effect 100% decoction has inhibitory effect on Staphylococcus aureus, S. typhi, Fusarium dysenteriae. It also has inhibitory effect on ringworm bacteria. No inhibitory effect on tuberculosis bacillus.
(6.) Other effects Inhibit the swelling of the feet caused by rat carrageenan and dextran. There is a mild antitussive effect. Morus alba extract alone has no effect on the frog dorsal muscle, but can make the frog abdominal rectus muscle tension increases. If the above two specimens were pre-treated with poisonous lentil alkaloids, the effect of Morus alba extract was significantly enhanced, and the secretion of rabbit parotid gland was mildly promoted. The in vitro inhibition rate of hot water extract of Morus alba Pi against human cervical cancer JTC-26 was about 70%.
13.10 ToxicitySangbaekpi by petroleum ether, ethanol, ether, acetic anhydride, water, ethyl acetate and other repeated treatment, the yellow powder, the mouse intravenous injection of the LD50 is 32.7mg/kg, while n-butanol extract or aqueous extract of the mouse gavage or intraperitoneal injection of 10g/kg, or intravenous injection of 5g/kg did not cause death. Whether the alcohol extract was given once in large quantities or several times in small quantities, the experimental animals did not show adverse effects, and it seems to be considered that the toxicity of the drug is relatively small.
13.11 ConcoctionsMulberry bark: brush off the gray debris, wash, moisten and cut silk, sun dry. Honey mulberry skin: take mulberry skin silk, add refined honey and a little water, mix well, a little bored, placed in the pan with a gentle fire fried until it becomes yellow, not sticky to the degree, remove, cool. (100 pounds of silk per mulberry skin, with 30 pounds of refined honey) "Lei Gong Gun Zhi Theory": Where to make (mulberry white skin) pick ten years has been on the young root, copper knife stripped on the green and yellow thin skin a heavy, only to take the second weight of white skimming the green salivation, with a copper knife forged, baked dry, do not make the skin salivation, salivation is the power of the drug. This medicine is evil iron and lead.
13.12 Taste and odorsweet; pungent; cold in nature
13.13 Meridianlung; spleen meridian
13.14 Functionslaxing the lungs and calming the wheezing; inducing diuresis to eliminate swelling. Lung heat, asthma and phlegm; water and drink in the lungs; fullness and asthma; edema; foot odor; dysuria
13.15 Usage and dosage of SangbaipiFor internal use: decoction, 915g; or in bulk. External use: appropriate amount, pounded juice or decoction wash.
13.16 PrecautionsNot to be taken for lung deficiency without fire power, excessive bowel movement and wind-cold cough.
1. "Collected Notes on the Classic of Materia Medica": Sequins, Gui Xin and Ma Gan are the enablers.
2. "The Classic of Materia Medica": the lungs are weak without fire, due to cold attack and cough do not take.
3. De Duai Ben Cao: It is used only when the lungs are deficient and there is a need to facilitate urination.
13.17 prescription① treatment of children's lungs, gas and cough: ground bone skin, mulberry white skin (fried) each one or two, licorice (roasted) a money. Frustration, into the prism of a handful of rice, water two small calendars, decoction seven minutes, before eating. (scrape, children's medicinal evidence straight "diarrhea from the scattered) ② cough very see, or spit blood Yin fresh: mulberry root white skin a catty. Rice bath soak three nights, net scraping on the yellow skin, frustrated fine, people glutinous rice four two, roasted, a pounded into the end. Each serving rice Chin mix down one, two money. ("Experience formula") ③ treatment of water drinking tide city, fullness and wheezing: mulberry root from the skin of two money, ephedra, cinnamon sticks, each one and a half cent, almonds 14 (peeled), fine Xin, dry ginger, each one and a half cent. Water decoction. ("Materia Medica Hui Yan") ④ treatment of urinary incontinence, swelling of the face and eyes: Sang Bai Pi four money, five money of Dong Gua Ren, grass seedling three money. Decoction soup. (Shanghai Commonly Used Chinese Herbs) ⑤ treatment of stroke urination, thirst: mulberry root from the skin, sizzling to make yellow and black, frustrated, boiled in water to make thick, feel free to drink; can also be a little rice, hasty use of salt. (After elbow prescription) (6) treatment of diabetes: mulberry from the skin of four money, five money to restrain the seeds. Decoction of soup. ("Shanghai commonly used Chinese herbs") (7) the treatment of infectious hepatitis: fresh mulberry white skin two two, sugar appropriate amount. Decocted in water, divided into two servings. ["Fujian Chinese Medicine" (3): 26, 1961] ⑧ treatment of postpartum blood: sizzling mulberry white skin, boiled water to drink. ("After Elbow Square") ⑨ treatment of pediatric urinary zaodan, the first from the two stocks, and the umbilicus, go to the head of the yin, all red: two liters of water, mulberry bark (cut) two liters, boil the juice, bath. ("Preparing for the emergency Qianjin Yaofang") ⑩ treatment of stone carbuncle firm as a stone, do not make pus: Sichuan mulberry root from the skin, drying and pounding the powder, feint glue, with wine and a number of swellings. ("dry gold formula") 11. Treatment of amusement ant poisoning: mulberry root bark pounded or decoction. ("Hunan Drugs") 12. Treatment of falling horse hoe damage: mulberry root white skin five pounds. For the end, a liter of water, decoction into a paste. Apply to the damage. ("Experience after the prescription")
13.18 various schools of thought1. Li Gao: Sang Bai Pi, sweet to solidify the deficiency of vital energy and tonifying the deficiency, Zai to diarrhea of the lungs of the excess of qi and stop coughing. And mulberry from the skin from the lungs, but the nature is not pure, should not be used more.
2. "Compendium of Materia Medica": Mulberry from the skin, long for the small water, is the real diarrhea of its son, so the lungs in the water and the lungs have more than the fire is advisable. Ten agent cloud, dry can go wet, mulberry white skin, red beans of the genus is carried forward. Song doctor Qian B treatment of lung heat, coughing and then wheezing, face swelling and body heat, diarrhea white powder. Mulberry from the skin, the ground call skin can be laxative fire from the urinal, licorice laxative fire and slow in the round-grained rice clear lung and blood, this is a diarrhea of the lungs of the quasi-criteria. Yuan doctor Luo Tianyi said it diarrhea in the lungs in the ambient fire and fill the positive gas, diarrhea evil so fill the positive also. If the lungs are weak and small convenient to see, should not be used.
3. "Drugs": mulberry bark, heat, the main treatment of wheezing and coughing, hot sputum spit blood, all by the real evil depression, the lung orifices are not open, this seepage of the dispersion, in order to benefit the lung gas, the evidence since the cure. Therefore, the cloud diarrhea of the lungs of the surplus, non-mulberry bark can not be. This treatment of skin membrane outside the water swelling and skin evil heat, floating wind dry itch, all can go. With chamomile, lentil nasal congestion heat congestion, combined with salvia, astragalus to stop intestinal red blood are effective.
13.19 Origin"Chinese Materia Medica"
14 Pharmacopoeia standard of SangbaipiSangbaipi
Sangbaipi
MORI CORTEX
14.2 SourceThis is the dried root bark of Morus alba L. of the family Moraceae. In late fall when the leaves fall to the next spring before the germination of the roots, scrape off the yellow-brown rough skin, longitudinal split, peeled root bark, sun-dried.
14.3 ShapeThe product is twisted coil, groove or plate sheet, length and width vary, 1 ~ 4mm thick. outer surface white or yellowish white, flat, some residual orange-yellow or brownish-yellow scale-like coarse skin; inner surface yellowish white or grayish yellow, with fine longitudinal lines. Light, tough, fibrous, difficult to break, easy to longitudinal tearing, tearing with dust. Gas slightly, taste slightly sweet.
14.4 Identification(1) cross-section of the product: phloem rays 2-6 columns of cells; scattered milk tube; fibers single scattered or bundled, non-woody or slightly wooded; thin-walled cells containing starch granules, some cells contain calcium oxalate square crystals. In older root bark, thick-walled cells scattered with clusters of stone cells, lumen mostly containing square crystals.
Powder grayish yellow. Fibers are numerous, broken, 13-26 μm in diameter, thick-walled, non-woody to slightly wooded. Calcium oxalate square crystals diameter 11 ~ 32 μm. stone cell class round, square or irregular shape, diameter 22 ~ 52 μm, wall thicker or very thick, pore and pore groove is obvious, some of the cell cavity containing square crystals. There are also crystal-containing thick-walled cells. There are many starch granules, the single granules are round, 4-16μm in diameter; the compound granules are composed of 2-8 grains.
(2) Take 2g of powder, add 20ml of saturated sodium carbonate solution, ultrasonic treatment for 20 minutes, filtration, filtrate with dilute hydrochloric acid to adjust the pH value to 1 ~ 2, 30 minutes, filtration, filtrate extracted with ethyl acetate shaking 2 times, each time 10 ml, combined with ethyl acetate, evaporated, residue with methanol lml to dissolve. As a test solution. Another take mulberry white bark control herb 2g, the same method into the control herb solution. According to the thin-layer chromatography (Appendix VIB) test, absorb the above two solutions of 5μl, respectively, point in the same polyamide film, acetic acid as the unfolding agent, unfolding about 10cm, remove, dry, and placed in the ultraviolet light (365nm) under the examination. The test chromatogram, in the corresponding position with the chromatogram of the control herb, the same two fluorescent spots.
14.5 Sang Bai Pi tablets 14.5.1 Concoction 14.5.1.1 Sang Bai Piwashed, slightly moist, shredded, dried.
14.5.1.1.1 IdentificationSame as the herb.
14.5.1.2 Honey Sangbai PiTake Sangbai Pi silk, according to the honey-roasted method (Appendix II D) fried until not sticky.
14.5.2 Flavor and MeridianSweet, cold. Attributed to the lung meridian.
14.5.3 Functions and IndicationsDiarrhea of the lungs, asthma, diuresis and edema. It is used for lung-heat asthma and cough, edema, distention and urination, and swelling of the face and skin.
14.5.4 Usage and dosage6~12g.
14.5.5 StorageIn a ventilated dry place, moisture-proof, moth-proof.
14.6 ProvenanceChinese People's Pharmacopoeia of 2010
15