The body's metabolism is also ultimately through the generation of lipase, fat biodegradation as metabolic waste discharge, can be biological direct synthesis of lipase, but most of the chemically synthesized lipase has no way to be directly absorbed by the body, cholesterol and other lipids and small molecules have an important biological function, but excessive cholesterol can cause atherosclerosis, which can lead to a series of serious coronary heart disease and stroke, and other serious diseases.

Therefore, lipid levels in the body must be tightly and precisely regulated. gp78, a ubiquitin-conjugating enzyme, regulates the degradation of a number of important proteins involved in cholesterol metabolism. The group found that gp78-deficient mice were lethargic, had reduced adiposity, were significantly resistant to high-fat diet and age-induced obesity, and exhibited enhanced insulin sensitivity.

The molecular mechanism is to reduce the synthesis of lipids such as cholesterol and fatty acids on the one hand, and to promote the consumption of large amounts of nutrients such as glucose and fatty acids on the other. This study identifies a link between lipid synthesis and energy metabolism and suggests that gp78 could be a target for the treatment of metabolic diseases such as obesity and diabetes.

Expanded Information:

I. Biological Functions:

Lipids refer to a class of substances that differ considerably in their chemical composition and structure, but all share a ****similarity of properties, i.e., insoluble in water but soluble in ether, water, and water. Water but soluble in ether, chloroform and other non-polar solvents. Usually lipids can be divided into five categories according to their different compositions, i.e. simple lipids, complex lipids, terpenoids and steroids and their derivatives, derived lipids and bound lipids.

Lipids have important biological functions. Lipids are energy providers for living organisms.

Lipids are also important components that make up living organisms, such as phospholipids, which are important components that make up biofilms, and oils and fats, which are the form of storage and transportation of fuels required for the metabolism of the organism. Lipids also provide the animal organism with essential fatty acids and fat-soluble vitamins dissolved in them.

Some terpenes and steroids such as vitamins A, D, E, K, bile acids and steroid hormones have nutritional, metabolic and regulatory functions. Lipids on the surface of the organism have a protective effect on preventing mechanical damage and heat dissipation. Lipids as a cell surface material, and cell recognition, species specificity and tissue immunity are closely related.

Two, fat introduction:

Fat is a triacylglyceride composed of glycerol and fatty acids, of which the molecule of glycerol is relatively simple, while the fatty acids are different types and lengths. Therefore the nature and characteristics of fats depend mainly on the fatty acids, and the types and contents of fatty acids contained in fats from different foods are not the same. There are more than 40 types of fatty acids in nature, and thus a variety of fatty acid triglycerides can be formed; fatty acids are generally composed of 4 to 24 carbon atoms.

Lipids in the human body, are divided into two parts, namely: fats and lipids. Fats, also known as true fats, neutral fats and triglycerides, are made by combining one molecule of glycerol with three molecules of fatty acids. Fats also include unsaturated and saturated, and animal fats contain more saturated fatty acids, which are solid at room temperature.

On the contrary, vegetable oils contain more unsaturated fatty acids and are liquid at room temperature. Lipids are cholesterol, lecithin, lecithin, and so on. Comprehensive its functions are: fat is a good intracellular energy storage material, mainly to provide heat energy; protection of internal organs, maintain body temperature; to assist the absorption of fat-soluble vitamins; involved in all aspects of the body's metabolic activities and so on.

References:

Baidu Encyclopedia - Fat