2 National Essential Drugs and Tianwang Buxin Pill related national essential drugs retail guidance price information
Serial number essential drugs
Directory serial number drug name dosage form specification unit retail refers to
Notes on price category 57 1 44 Tianwang Buxin Pill, Honey Pill, 9g Pill, 0.79 Chinese patent medicine part * 572 44 Tianwang Buxin Pill 36g bottle 2.9 Chinese patent medicine part 573 44 Tianwang Buxin Pill 54g bottle 4.2 Chinese patent medicine part 574 44 Tianwang Buxin Pill 60g bottle 4.6 Chinese patent medicine part 575 44 Tianwang Buxin Pill 1 20g bottle of 8.7 Chinese patent medicine part 576 44 Tianwang Buxin Pill Shuimi Pill 6g bag 0.95 Chinese patent medicine part 577 44 Tianwang Buxin Pill Shuimi Pill 12g bag 1 .9 Chinese patent medicine part 578 44 Tianwang Buxin Pill Shuimi Pill 36g bottle 5.7 Chinese patent medicine part 579 44 Tianwang Buxin Pill Shuimi Pill 40g bottle 6.3 Chinese patent medicine part 580 44 Tianwang Buxin Pill Shuimi Pill 48g bottle 7.6 Chinese patent medicine part 58 1 44 Tianwang Buxin Pill Shuimi Pill 54g bottle 8.5 Chinese patent medicine part 582 44 Tianwang Buxin Pill Shuimi Pill 60g bottle 9.5 Chinese patent medicine part 583 44 Tianwang Buxin Pill Shuimi Pill 72g bottle 1 1.4 Chinese patent medicine part 584 44 Tianwang Buxin Pill Concentrated Pill 200 pill bottle 9.6 Chinese patent medicine part * △ 585 44 Tianwang Buxin Pill Concentrated Pill 48 Pill Bottle 2.4 Chinese Patent Medicine Part 586 44 Tianwang Buxin Pill Concentrated Pill 180 Pill Bottle 8.7 Chinese Patent Medicine Part 587 44 Tianwang Buxin Pill Concentrated Pill 192 Pill Bottle 9.2 Chinese Patent Medicine Part 588 44 Tianwang Buxin Pill Concentrated Pill 2 1 6 pill bottles 10.3 Chinese patent medicine part 589 44 Tianwang Buxin Pill Concentrated Pill 240 pill bottles1.4 Chinese patent medicine part 590 44 Tianwang Buxin Pill Concentrated Pill 300 pill bottles 14.2 Chinese patent medicine part 59 1 44 Tianwang Buxin Pill Concentrated Pill 360 pill bottles/.
1, dosage form specifications marked with "*" in the remarks column in the table are representative products.
2. Specifications of dosage forms marked with "△" in the remarks column in the table, and other specifications of the same dosage form are temporary prices.
3. The dosage form specifications are indicated in the remarks column. The prices of other specifications in this dosage form are based on the same usage and dosage, and are calculated according to the Drug Price Comparison Rules.
4. The "honey pills" marked in the dosage form column in the table include small honey pills and big honey pills.
3 Pharmacopoeia Standard of Tianwang Buxin Pill 3. 1 Name Tianwang Buxin Pill
Tianwang Buxin Wan
3.2 Prescription Salvia miltiorrhiza 25g, Angelica sinensis 50g, Acorus gramineus 25g, Codonopsis pilosula 25g, Poria 25g, Schisandra chinensis 50g, Ophiopogon japonicus 50g, Radix Asparagi 50g, Rehmannia glutinosa 200g, Scrophularia 25g, Radix Polygalae 25g, Semen Ziziphi Spinosae 50g, Semen Platycladi 50g, Radix Platycodi 25g, Radix Glycyrrhizae 25g, Cinnabaris 10g.
3.3 Make the above sixteen flavors, and the cinnabar water will fly into very fine powder; The other fifteen herbs, such as Salvia Miltiorrhiza, are pulverized into fine powder, mixed with the above powder, sieved and evenly mixed. Every 100g powder is watered with 20-30g refined honey, dried and made into honey pills; Or adding 50-70g refined honey to make small honey pills or big honey pills.
3.4 Characteristics This product is a brown-black honey pill, a brown-black small honey pill or a big honey pill; The gas is slightly fragrant, sweet and slightly bitter.
3.5 Identification (1) Take this product and observe it under a microscope: the irregular branched mass is colorless and dissolves in chloral hydrate test solution; The mycelium is colorless or light brown, with a diameter of 4 ~ 6 μ m (Poria cocos). Stone cells are rhombic or polygonal, with a slightly sharp end, thick walls and sparse pits (Codonopsis pilosula). Stone cells are yellowish brown or colorless, rectangular, round or irregular in shape, with obvious layering and a diameter of about 94μm (Scrophularia). The stone cells are rectangular or long, with a diameter of 50 ~110μ m and extremely fine pits (asparagus). The stone cells in the epidermis of seed coat are yellowish or yellowish brown, with polygonal surface, thick wall, fine pores and grooves, and dark brown substance (Schisandra chinensis) in the cell cavity. Needle crystals of calcium oxalate are in bundles or scattered, with a length of 24 ~ 50μ m and a diameter of about 3μm (Ophiopogon japonicus). The diameter of the connective laticifer is14 ~ 25μ m, containing yellowish granules (platycodon grandiflorum). The parenchyma is grayish brown to dark brown, and the cells are mostly shriveled, containing brown nuclei (Rehmannia glutinosa). The parenchyma cells around the fiber bundle contain calcium oxalate crystals, forming crystalline fibers (licorice). Endotesta cells are brownish yellow, rectangular or square on the surface, and the vertical wall is beaded (fried Ziziphus jujuba seeds). Irregular fine particles are dark brown-red, shiny, with dark black edges (cinnabar).
(2) Take this product 1g and mash it with honey pills; Cut small honey pills or big honey pills, lay them flat in a crucible, cover them with a long-handled funnel, heat them slowly, stop heating until the powder is slightly burnt, let them cool, remove the funnel, wash the inner wall with 5ml of water, and observe the lotion under an ultraviolet lamp (365nm), showing light blue-green fluorescence.
(3) Take 4.5g of this product, wash it with water to obtain a small amount of vermilion precipitate, take it out, moisten it with hydrochloric acid, and gently rub it on the smooth copper sheet, the surface of the copper sheet will show silvery white luster, and after heating and baking, the silvery white will disappear.
(4) take this product honey pill 18g, and grind it; Or take 27g of small honey pills or big honey pills, cut them into pieces, add water 100ml, perform ultrasonic treatment for 30 minutes, adjust the pH value to 2 with hydrochloric acid, filter, shake and extract the filtrate with ether for 3 times, each time 60ml, combine ether extracts, volatilize the ether, and add methanol 1ml to the residue to dissolve it as a test solution. Another protocatechuic acid reference substance was added with methanol to prepare a solution containing 1mg per 1ml as the reference substance solution. According to the test of thin-layer chromatography (Appendix ⅵ b of Pharmacopoeia I of 20 10 edition), sample solution 10μl and reference solution 3μl were respectively spotted on the same silica gel GF254nm thin-layer plate, and chloroform-acetone-formic acid (8:1:0.8) was used as developing agent. In the chromatogram of the test sample, the spots with the same color appear at the position corresponding to the chromatogram of the reference sample, and then they are smoked in iodine vapor to show the same brown spots.
(5) Take 30g of honey pills of this product and grind them; Or take 30g of small honey pills or big honey pills, cut them into pieces, put them into a 250ml round-bottomed flask, add water 100ml, distill, collect 50ml of distillate, shake and extract with petroleum ether (60-90℃) twice, 20ml each time, combine petroleum ether extracts, evaporate to dryness, and add ethyl acetate 1ml to the residue to dissolve. Another reference material of Acorus gramineus 1g was added with 50ml of water to prepare a reference material solution by the same method; 2g of Angelica sinensis reference medicinal material was taken, and 20ml of ethyl acetate was added for ultrasonic treatment for 20 minutes. After filtration, the filtrate was evaporated, and the residue was dissolved by adding ethyl acetate 1ml as reference medicinal material solution. According to the test of thin-layer chromatography (appendix ⅵ b of Pharmacopoeia I, 20 10 edition), absorb each 1μl of the above three solutions, respectively spot them on the same silica gel G thin-layer plate, unfold them with cyclohexane-ethyl acetate (9:1) as the developing agent, take them out, dry them, and place them in an ultraviolet lamp (365nm). In the chromatogram of the test sample, fluorescent spots with the same color are displayed at the corresponding positions of the chromatogram of angelica sinensis. Smoked in iodine vapor and examined in sunlight, spots of the same color appeared in the position corresponding to the chromatogram of Acorus gramineus.
(6) Take 6g of honey pills of this product and grind them; Or take 6g of small honey pills or big honey pills, cut into pieces, add ether 100ml, heat and reflux 1 hour, discard the ether solution, evaporate the solvent from the residue, add methanol 100ml, heat and reflux 1 hour, let cool, filter, evaporate the filtrate, and add 40% water to the residue. Wash with water saturated with n-butanol for 3 times, 30ml each time, discard the water washing solution, evaporate the n-butanol solution to dryness, and add methanol 1ml to the residue to dissolve it as the test solution. Another reference medicinal material 1g of Glycyrrhiza uralensis Fisch was taken, and 40ml of ether was added to make a reference medicinal material solution by the same method (the amount of methanol was 30ml). According to the test of thin-layer chromatography (Appendix ⅵ b of Pharmacopoeia I, 20 10 edition), 2μl of each of the above two solutions was absorbed and spotted on the same silica gel G thin-layer plate, with ethyl acetate-formic acid-glacial acetic acid-water (15:1:kloc-0/:2) as the development. In the chromatogram of the test sample, the spots with the same color appear at the positions corresponding to the chromatogram of the control medicinal materials.
3.6 The inspection shall comply with the relevant provisions under pills (Appendix 1A of Pharmacopoeia I, 20 10 edition).
3.7 The content was determined by high performance liquid chromatography (Appendix ⅵ D of Pharmacopoeia I, 20 10 edition).
3.7. 1 chromatographic conditions and system applicability test with octadecylsilane bonded silica gel as filler; Using methanol-water (45: 55) as mobile phase; The detection wavelength is 250nm. The theoretical plate number should be no less than 6000 according to the calculation of schisandrin A peak.
3.7.2 Preparation of Reference Solution Take an appropriate amount of Schisandrin A reference substance, weigh it accurately, and add methanol to make a solution containing 20μg per kloc-0/ml.
3.7.3 Preparation of test solution Take a proper amount of honey pills of this product, grind them into fine powder, take about 1g, and weigh them accurately; Or take an appropriate amount of honey pills, cut them into pieces, take an appropriate amount, accurately weigh them, accurately add the same amount of diatomite, grind them evenly, take about 3g, and accurately weigh them; Or take honey pills with weight difference, cut them into pieces, mix them evenly, take an appropriate amount, accurately weigh them, accurately add twice the amount of diatomite, grind them evenly, take about 4.5g, accurately weigh them, put them in a conical flask with a stopper, accurately add 20ml of methanol, tightly plug them, weigh them, and perform ultrasonic treatment (power 180W, frequency 50 khz) for 30 minutes.
3.7.4 Determination method Accurately suck each 10μl of the reference solution and the test solution, inject them into the liquid chromatograph, and determine to obtain the product.
The content of Schisandra chinensis in this product is calculated as schisandrin A (C24H32O7), and the honey pill should not be less than 0. 1g; Every 1g of Xiaomi pill shall not be less than 0.13 mg; Damiwan shall not be less than 1.22mg per pill.
3.8 Functions and indications: nourishing yin and blood, nourishing the heart and calming the nerves. Used for deficiency of heart yin, palpitation and forgetfulness, insomnia and dreaminess, and dry stool.
3.9 Usage and dosage for oral administration. Shuimi Pill is 6g once, Xiaomi Pill is 9g once, Daimi Pill is 1g once 1 pill, twice a day.
3. 10 specification honey pills weigh 9g each.
3. 1 1 storage and sealing.
3. 12 Edition "Pharmacopoeia of the People's Republic of China" 20 10 Edition
4. Standards issued by the Ministry of Traditional Chinese Medicine of Tianwangbuxin Pill 4. 1 Pinyin name Tianwang Buxin Wan
4.2 standard number WS3B 150393
4.3 Prescription Salvia Miltiorrhiza 25g Angelica 50g Codonopsis 25g Acorus gramineus 25g Poria 25g Schisandra 50g Ophiopogon japonicus 50g Asparagus 50g Rehmannia 200g Scrophularia 25g Platycodon grandiflorum 25g Radix Polygalae 25g Glycyrrhizae 25g Ziziphus Spinosae Seed (fried) 50g Cinnabar 10g.
4.4 Prepare the above sixteen herbs by pulverizing 25g of Radix Angelicae Sinensis, Radix Salviae Miltiorrhizae, Radix Codonopsis, Poria, Radix Platycodi and Radix Ophiopogonis into fine powder, and grinding with the above powder; Rehmannia glutinosa is decocted in water for three times, the first time is 3 hours, the second time is 2 hours, and the third time is 1 hour, the decoctions are combined, filtered, and the filtrate is concentrated into a thick paste with a relative density of1.30 ~1.35 (20℃); Decocting the remaining eight herbs, such as Ophiopogon japonicus and Schisandra chinensis, in water for two times, with the first time lasting for 3 hours and the second time lasting for 2 hours, combining the decoctions, filtering, and concentrating the filtrate into a thick paste with a relative density of1.30 ~1.35 (20℃); Mixing the above fine powders and soft extracts, making pills, drying, and polishing.
4.5 Characteristics This product is a brown-black concentrated pill; The gas is slightly fragrant, sweet and bitter.
4.6 Identification (1) Take this product and observe it under the microscope: the cork cells are reddish brown with rectangular or polygonal walls. Irregular granular lumps and branched lumps are colorless and dissolve in chloral hydrate solution; The mycelium is colorless or light brown, with a diameter of 3 ~ 8 μ m. Stone cells are square, rectangular or polygonal, and the wall is not very thick, which is often located on the surface of cork tissue fragments. The phloem parenchyma cells are spindle-shaped, with slightly thick walls and extremely fine oblique staggered textures on the surface. It can be seen that the thin diaphragmatic mammary ducts are connected with each other, with a diameter of14 ~ 25μ m, and the ducts contain tiny light yellow oil-drop-like particles. The needle crystal length of calcium oxalate needle crystal bundle is 24 ~ 50 μ m and the diameter is about 3 μ m. Irregular fine particles are dark brown-red, shiny, with dark black edges.
(2) Take 5 pills of this product, mash them, wash them with water to get a small amount of vermilion precipitate, take them out, moisten them with hydrochloric acid, and gently rub them on the smooth copper sheet, the surface of the copper sheet will show silvery white luster, and after heating and baking, the silvery white will disappear.
4.7 The inspection shall comply with the relevant regulations under Pills (Appendix 8).
4.8 Functions and indications: nourishing yin, nourishing blood, nourishing heart and calming nerves. Used for deficiency of heart yin, palpitation and forgetfulness, insomnia and dreaminess, and dry stool.
4.9 Usage and dosage Take orally, 8 pills at a time, 3 times a day.
4. 10 specification Every 8 pills is equivalent to 3g of the original medicinal materials.
4. 1 1 storage seal
5 "Puji Recipe" Volume 375 Tianwang Buxin Pill 5. 1 Composition cinnabar (half coat) 3 money, Pinellia ternata (soaking 10 day, changing water 10 times, stirring every time 1 time) 3 money, Ginseng 3 money, Aristolochia 3 money. Musk 1 money, Radix Aristolochiae 1 money, Areca catechu 1 money, Semen Lepidii (parched yellow) 1 money, and 7 capsules of Jiangzi (peeled and degreased).
5.2 Indications: Tianwang Buxin Pill, Volume 375 of Puji Recipe, is used to treat children with acute and slow convulsions.
5.3 Usage and dosage of Tianwang Buxin Pill: 57 pills per dose 1 year, and 3 pills per year 14; Decrease the number of pills for the weak, and increase the number of pills for the strong; Schizonepeta soup is sent down.
5.4 The preparation method is fine powder, and the batter is pills, such as radish seeds and cinnabar.
5.5 Note: We made honey pills with gold foil as the coat, and named them as "Gold Foil Pills for Relieving the Heart" (see the same volume in the original book).
6 "Yang's Family Tibetan Prescription" Volume 10 Tianwang Buxin Pill 6. 1 Tianwang Buxin Pill's alias Tianwang Buxin Pill
6.2 The composition of cooked dried Rehmannia glutinosa (washed and baked) is 4 Liang, Poria cocos (peeled) 1 Liang, Poria (removed wood) 1 Liang, Angelica sinensis (washed and baked) 1 Liang, Polygalae Radix (cored) 1 Liang, and Acorus Graminei. Ophiopogon japonicus (cored) 1 2, Ophiopogon japonicus (cored) 1 2, Platycodon grandiflorum (cored) 1 2, Stemona Stemona 1 2, Platycladus orientalis 1 2, Eucommia ulmoides Oliv (fried with ginger juice)/
6.3 Efficacy The Tianwang Buxin Pill in Volume 10 of Yang's Family Tibetan Prescription has the functions of calming the heart and protecting the spirit, benefiting the blood and solidifying the essence, and strengthening the mind, which is unforgettable; Clearing triple energizer, eliminating phlegm and saliva, removing vexation and heat, removing fright, treating dry throat and mouth, and nourishing heart qi.
6.4 Indications Tianwang Buxin Pill, Volume 10 of Yang's Family Tibetan Prescription, is indicated for heart and kidney deficiency, dizziness and restlessness.
6.5 Usage and dosage of Tianwang Buxin Pill 1 pill. After eating, decoct Dengxin and Jujube in soup.
6.6 The preparation method is fine powder, refined honey as pills, each 1 two pills 10 pills, and gold foil as coating.
6.7 Note Tian Wang Bu Xin Dan (Volume 7 of De Xiao).
7 "Criterion Leifang" Volume 5 Tianwang Buxin Pill 7. 1 Composition Ginseng (removing reed) 5 Yuan, Angelica sinensis (soaked in wine) 1 2, Schisandra chinensis 1 2, Ophiopogon japonicus (removing heart) 1 2, Asparagus (removing heart).
7.2 Efficacy Tianwang Buxin Pill, Volume 5 of Criterion Leifang, has the functions of calming the heart and protecting the spirit, benefiting the blood and consolidating the essence, and strengthening the mind, which is unforgettable; It has the effects of eliminating stagnation, calming fright, clearing triple energizer, eliminating phlegm and saliva, relieving vexation and heat, curing dry throat and nourishing mind.
7.3 Usage and Dosage of Tianwang Buxin Pill: 2030 pills per serving, and delivered with Dengcao and Zhuye decoction when lying in bed.
7.4 The preparation method is powder, refined honey is pills, such as buttonwood, cinnabar is clothes.
8 Instructions for Tianwang Buxin Pill 8. 1 Drug Name Tianwang Buxin Pill
8.2 Formulation of honey pills: 9g per pill.
8.3 The main components of Tianwangbuxin Pill are Salvia Miltiorrhiza, Angelica sinensis, Acorus gramineus, Codonopsis pilosula, Poria, Schisandra chinensis, Ophiopogon japonicus, Asparagus, Rehmannia glutinosa, Scrophularia, Polygalae Radix (processed), Ziziphus Spinosae Semen (fried), Platycladus orientalis, Platycodon grandiflorum, Glycyrrhiza uralensis and Cinnabaris.
8.4 The function of Tianwang Buxin Pill is mainly to nourish yin and blood, replenish the heart and soothe the nerves. Used for heart yin deficiency, palpitation, forgetfulness, insomnia, dreaminess and dry stool.
8.5 Precautions 1. It is forbidden for those with yang deficiency and cold excess, warm connotation, spleen and stomach deficiency and cold, poor appetite and retention of phlegm and dampness.
2. Avoid garlic, coriander, radish, fishy smell and shochu.
8.6 Usage and dosage of Tianwang Buxin Pill