Human serum is divided into many indicators. No matter which indicator has problems, it will cause bad situations for people, so we should understand the meaning of these indicators. One of them is called Serum alkaline phosphatase, many people are unfamiliar with serum alkaline phosphatase, so where does serum alkaline phosphatase come from?
What is serum alkaline phosphatase?
Many people don’t know much about the term serum alkaline phosphatase, so let’s talk about serum alkaline phosphatase next.
Alkaline phosphatase is a phosphomonoester hydrolase and is a group of specific phosphatase. This enzyme is widely distributed in human tissues and body fluids, with higher content in bones, liver, breast, small intestine, and kidney. Most of it is produced by bone cells, and a small part comes from the liver and is excreted into the intestine through bile. ALP measurement methods are mainly colorimetric methods and continuous monitoring methods.
High alkaline phosphatase indicates liver abnormalities. When alkaline phosphatase is high, it may be liver cysts, liver tuberculosis, obstructive jaundice, secondary liver cancer, primary liver cancer, etc.; High alkaline phosphatase indicates bone disease. When alkaline phosphatase is high, it may be osteomalacia, fracture healing period, osteocyte cancer and malignant tumor bone metastasis.
Normal value of serum alkaline phosphatase
Serum alkaline phosphatase also needs to be checked during the examination, so what is the normal value of serum alkaline phosphatase? ?
Reference for normal values ??of serum alkaline phosphatase: For females, 1-12 years old, less than 500U/L; over 15 years old, 40-150U/L. For males, 1-12 years old, less than 500U/L; 12-15 years old, less than 750U/L; older than 15 years old, 40-150U/L. Whether the serum alkaline phosphatase test value is normal or not is related to judging the degree of liver cell damage.
About half of primary liver cancers and 90% of metastatic liver cancers have elevated levels of ALP, and the increase is most significant in liver diseases. Abnormally elevated ALP in patients without jaundice should alert them to the possibility of liver cancer. ALP may also be elevated in other tumors.
What is the reason for high serum alkaline phosphatase
Some people have done a serum alkaline phosphorus test and found that their serum alkaline phosphatase is high, then the serum alkaline phosphatase What's the matter with high enzyme?
We all know that hepatitis is very harmful to the human body, so it requires timely treatment. It is recommended that patients with high alkaline phosphatase should go to a regular hospital for examination in time to avoid delaying the best treatment time.
The reasons for high alkaline phosphatase are physiological and pathological. The pathological reason is that when the human body suffers from liver cancer, obstructive jaundice, cholestatic hepatitis and other diseases, the liver cells overproduce AL. (a zinc-containing glycoprotein), causing an increase in alkaline phosphatase in the serum. It is recommended that further examination be performed, and if the cause is pathological, the primary disease causing the elevated alkaline phosphatase should be treated.
The significance of testing serum alkaline phosphatase
Serum alkaline phosphatase is actually not understood by many people now, but in fact, testing serum alkaline phosphatase also has its own uses. Yes, then what is the significance of testing serum alkaline phosphatase?
Alkaline phosphatase is widely distributed in human bones, liver, intestines, placenta and other tissues. The normal value is 3~13 units/liter (Golden-Ash method). It is mainly used for obstructive jaundice. , examination of primary liver cancer, secondary liver cancer, and cholestatic hepatitis.
Alkaline phosphatase testing is mainly used to detect obstructive jaundice, primary liver cancer, secondary liver cancer, and cholestatic hepatitis.
When suffering from these diseases, liver cells overproduce ALP and enter the blood through lymphatic channels and liver sinusoids. At the same time, due to intrahepatic bile duct bile excretion disorders, reflux into blood causes a significant increase in serum alkaline phosphatase. Testing serum alkaline phosphatase can detect various diseases.