1. Physiological causes
Children's bone development, pregnant women, and bone fracture healing period, the alkaline phosphatase in the bone tissues is very active in these cases, so the value will be high in the test.
2. Pathological causes
When the human body suffers from obstructive jaundice, primary liver cancer, secondary liver cancer, cholestatic hepatitis, etc., the liver cells overproduce ALP, which enters into the bloodstream through the lymphatic channels and hepatic sinusoids, and at the same time, due to the obstacle of the excretion of bile, the backflow into the bloodstream, which causes the alkaline phosphatase in the serum to be high.
Also, if a person suffers from rickets, osteoclast carcinoma, osteoporosis, hepatic sclerosis, leukemia, and hyperthyroidism, the alkaline phosphatase in the serum will also be high [1].