This is a genetic disease. The patient's body lacks glucose 6- phosphate dehydrogenase (G-6-PD) because of the lack or absence of G-6- PD gene that produces glucose 6-phosphate dehydrogenase (G-6-PD).

An unknown substance contained in broad beans cannot be decomposed by patients, and acute hemolytic anemia occurs after contact with silkworm peas, branches and leaves and pollen.

Sudden onset, sudden chills, high fever, pale face, backache, shortness of breath, fatigue, irritability, nausea, vomiting, abdominal pain and other gastrointestinal symptoms. This is due to the massive destruction of red blood cells and the toxic effects of their decomposition products on the body. When the concentration of free hemoglobin in plasma exceeds 130mg%, it is excreted through urine, resulting in hemoglobinuria, and the urine color is like strong black tea or soy sauce.

Jaundice can appear after 12 hours, and hemolytic products can damage renal tubular cells, cause renal tubular necrosis and hemoglobin deposition, weaken peripheral circulation, and lead to acute renal failure.

Due to anemia and hypoxia, severe cases can cause unconsciousness or coma, shock and cardiac insufficiency.