1, nutritional evaluation
Genetically modified foods are all expressed by foreign genes, and new varieties similar to gene receptors appear, so. The primary research task should be to analyze the nutritional components and chemical properties of traditional food and genetically modified food basically equally.
Nutritional evaluation mainly focuses on protein, starch, cellulose, fat, amino acids, fatty acids, carbohydrates, vitamins, mineral elements and other substances closely related to human health and nutrition, as well as anti-nutritional factors (phytic acid, protease inhibitors, tannins, etc. ). If there is a statistical difference compared with traditional food, we should fully consider whether this difference is within the reference range of this kind of food.
2. Toxicological evaluation
Toxicological evaluation mainly includes the evaluation of foreign gene expression products and the toxicological detection of whole food. The evaluation of foreign gene expression products is mainly through bioinformatics analysis.
Compared with the amino acid sequences of known toxic proteins to see their homology, followed by simulated gastrointestinal digestion and thermal stability tests, as well as acute toxic rodent tests. According to the expression products produced by foreign genes, the acute toxicity, genotoxicity (teratogenic test: sperm abnormality test, bone marrow micronucleus test, Ames test), subchronic toxicity, chronic toxicity and immunotoxicity can be tested when necessary.
Extended data:
The origin of security problems
1.In 1960s, PaulBerg made the world's first recombinant DNA by combining simian virus SV40 with the blunt end of E.coli DNA fragment.
2. At the meeting of 197 1 Cold Spring Harbor, RobeaPollack proposed that SV40 is a tumor virus, which may become a potential carcinogen when released into nature, so the experiment was terminated.
3. This meeting is the 1 recombinant DNA safety meeting. The following year, the European Molecular Laboratory (EMBO) specially discussed the potential hazards of gene recombination technology. 1973 on June 13, the safety of genetically modified crops was discussed at the Gordon meeting in the United States, and some related suggestions were put forward.
References:
Baidu encyclopedia-genetically modified food