zhì gān cǎo tāng
2 English referencezhigancao decoction [Nomenclature of Traditional Chinese Medicine (2004)], a Chinese medical terminology review committee. Nomenclature of Chinese Medicine (2004)]
Fried Glycyrrhizae Decoction [Xiangya Medical Professional Dictionary]
3 OverviewThere are about two formulas with the same name, of which the one recorded in Typhoid Fever is the commonly used one, which consists of 12g of Fried Glycyrrhizae decoction, 9g of ginger, 9g of cinnamon stick, 6g of ginseng, 30g of Radix et rhizoma Rhei, 6g of gelatin, and 6g of wheat germ (melted). melted) 6g, Maimendong 10g, Ma Ren 10g, jujube 10. It has the effect of benefiting qi, nourishing yin, and restoring yang and veins. This formula is used to treat the cardiac vein loss of nourishment caused by deficiency of qi and blood, and is a supplement for yin and yang, qi and blood. Modern commonly used in functional arrhythmia, extrasystole, coronary heart disease, rheumatic heart disease, viral myocarditis, hyperthyroidism and other palpitations, shortness of breath, pulse knot generation, etc. belongs to the deficiency of yin and blood, yang qi weak evidence.
4 "Typhoid fever" formula of roasted licorice soupClinical reports with roasted licorice soup for the treatment of morbid sinus node syndrome 11 cases, of which 4 cases of significant effect, 11 cases of effective, the effective rate of 100%, indicating that the formula of the arrhythmia does have a therapeutic effect, and at the same time on the primary causes of arrhythmia, hyperthyroidism, rheumatic heart disease, viral myocarditis, etc., but also through the immune, antioxidant, anti-inflammatory, and improve blood circulation mechanisms and play a therapeutic role in the treatment of the heart, the heart is not only the cause of the disease, but also to improve blood circulation. It also exerts therapeutic effects on the primary causes of arrhythmia, hyperthyroidism, rheumatic heart disease, viral myocarditis, etc. through immune, antioxidant, anti-inflammatory and improving blood circulation mechanisms. The effects of this formula on the regulation of neurological and endocrine functions as well as on cellular functions cannot be ignored, and this is where its "nourishing yin and nourishing blood" effect comes in, and its "benefiting qi and nourishing yin" effect may be related to its effects on the regulation of neurological and endocrine functions, the promotion and regulation of immunity and the positive effects on the heart, blood vessels and hemorheology. The positive effects on blood vessels and blood rheology are related to the regulation of nerve and endocrine functions, immune promotion and regulation, and the positive effects on the heart. [1]
4.1 Alias of Scorched Licorice Tang
Fuxue Tang ("Treatise on Typhoid Fever").
4.2 IngredientsFour taels of licorice (roasted), three taels of ginger (cut), two taels of ginseng, one catty of raw rhizome, three taels of cinnamon (peeled), two taels of Colla Corii asiatica, half a liter of maitake (removed from the heart), half a liter of hemp kernel, and thirty jujubes (broken) [2].
12g of scorched licorice, 9g of ginger, 9g of cinnamon stick, 6g of ginseng, 30g of Radix et Rhizoma Dioscoreae, 6g of Colla Corii Asini (melted), 10g of Ophiopogon flexuosus, 10g of Pinellia ternata, and 10 jujubes[3]
12g of licorice (sizzling), 9g of ginger (sliced), 6g of ginseng, 30g of Radix et Rhizoma Dioscoreae, 9g of cinnamon stick (peeled), 6g of Colla Corii Asini, 10g of Ophiopogon flexuosus (removed), 10g of Pinellia ternata, 30 jujubes. (Breaking)
Glycyrrhiza glabra (roasted) 12g, ginger (cut) 9g, cinnamon sticks (peeled) 9g, ginseng 6g, Radix et Rhizoma Dioscoreae 50g, Colla Corii Asini 6g, Ophiopogon 10g (heart removed) 10g, Asiatica 10g, Jujubae 10[4]
4.3 Method of UseThe above seven liters of clear wine, eight liters of water, the first eight flavors to be boiled, extracted three liters, remove the dregs, the gelatin closed to eliminate the exhaustion of a liters, warm, three times a day[2
Add 10 ml of wine, water decoction. [3]
Nine flavors of the above medicines, 10 ml of wine, add 800 ml of water, first boiled eight flavors, take 300 ml, remove the dregs, the gelatin melt away, take 100 ml of warm, three times a day.
On the seven liters of wine, eight liters of water, first boiled eight flavors, take three liters, remove the dregs, the gelatine melt away, take a liter of warm service, three times a day. [4]
4.4 Efficacy and treatment[3]
The effect of the broiled licorice soup is to benefit the qi and nourish the yin, pass the yang and restore the pulse. Indications:
1. Weakness of qi and blood, loss of nourishment of the heart and veins. Symptoms see the pulse knot generation, heart palpitations, false win less gas, tongue light less moss, or dry and thin.
2. Lung impotence. Symptoms such as dry cough without sputum, or coughing and spitting saliva, small amount, thin and short of breath, false annoyance, insomnia, sweating and night sweating, dry throat and tongue, dry and knotty stools, pulse counting.
4.5 Explanation of the formulaHaking Licorice Soup is used to treat heart vein loss due to deficiency of qi and blood, and it is recommended to benefit qi and nourish yin, and pass the yang to restore the vein. The formula emphasizes the use of roasted licorice and raw huang to benefit qi, nourish yin and nourish blood. Ginseng and jujube benefit the heart qi and tonify the spleen; Colla Corii Asini, Ophiopogon, Maidenhair, and Ma Ren nourish the heart yin and nourish the heart blood, **** for the subject. Gui Zhi, Ginger, and Wine are used as adjuvants to warm the heart, warm the heart yang, and open the blood channels. The combination of all drugs, warm but not dry, nourishing but not greasy, *** play the benefit of qi and blood, nourish yin and restore the power of the pulse. [3]
Scorched licorice soup original treatment of typhoid fever pulse junction generation, heart palpitations, is due to the lack of yin and blood, yang qi weakness. Insufficient yin and blood, the blood can not be filled; yang qi weakness, the inability to drum the blood, the pulse is not connected, so the pulse knot generation, heart palpitations. The treatment is to nourish the yin of the heart, nourish the blood of the heart, benefit the qi of the heart and warm the yang of the heart to restore the pulse and stabilize the palpitation. The formula emphasizes the use of Radix Rehmanniae Praeparata to nourish yin and nourish blood as the ruler. With roasted licorice, ginseng, jujube benefit heart qi, tonifying the spleen, in order to capitalize the source of qi and blood biochemistry; Colla Corii Asini, Ophiopogon, hemp kernel nourish heart yin, nourish the heart and blood, filling the blood pulse, **** for the subject medicine. Adjuvant Gui Zhi, ginger pungent and warm go scattered, warm heart Yang, through the blood. The combination of all medicines, so that the yin blood sufficient and blood, yang qi sufficient and the heart through, *** into the yin and yang qi and blood and complementary agent. In this way, qi and blood are sufficient, yin and yang are harmonized, palpitation is fixed and pulse is restored, so this formula is also known as "Restoring Pulse Soup". The use of wine decoction, to clear the wine pungent heat, can be warmed through the blood, in order to line the power of the drug. [4]
4.6 Clinical applicationScorched licorice soup is a tonic for yin and yang, qi and blood. Clinically, the main points of treatment are the knotting of the pulse, palpitations of the heart, less gas, and the tongue is light and pale with little moss. [3]
4.6.1 Addition and subtractionThe formula can add sour jujube nut and cypress kernel to enhance the power to nourish the heart and calm the mind to settle palpitations, or add dragon's tooth and magnetite to calm the mind; for those who are deficient in heart qi, reuse roasted licorice and ginseng; for those who are deficient in yin and blood, reuse Radix et Rhizoma Shengdi and Maitake Maitake; for those who have a deficiency in heart yang, easy Gui Zhi is used as cinnamon, and Radix et Rhizoma Polygoni Multiflori is used to increase the power of warming the heart yang; for those who are deficient in yin and have a high level of internal heat, easy ginseng is used as Nansha Ginseng and the power of Gui, Jiang, Jujube, wine and other medicines are reduced. Gui, ginger, jujube, wine, add Zhimu, cypress, then nourish Yin fluid to lower the power of the fire is stronger. [3]
4.7 Modern indications[5]
The use of licorice soup for functional arrhythmias and extrasystoles has been shown to be effective. For coronary heart disease, rheumatic heart disease, viral myocarditis, hyperthyroidism and other palpitations, shortness of breath, pulse knot on behalf of the present, belonging to the deficiency of yin and blood, heart qi weakness, can be added and subtracted, and can be used for qi and yin injuries such as dry cough of deficiency labor.
4.7.1 HyperthyroidismThe most common cause of hyperthyroidism is diffuse toxic goiter (Graves' disease), which is now recognized to be related to autoimmunity, but the mechanism of the abnormal function of the immune system is still unclear, and there are mainly the following doctrines: ① Disorders of the immune tolerance system. Loss of the function of the thymus or peripheral links to clear autoreactive T cells, which leads to the attack of such autoreactive T cells on thyroid tissues. (ii) Abnormal expression of immune-associated proteins on the surface of thyroid cells, causing them to become antigen-presenting cells and inducing and exacerbating autoimmune reactions against the thyroid gland. (iii) Functional defects of specific suppressor T cells determined by genetic background, leading to enhanced function of helper T cells and B cells. Also environmental and infectious factors are involved in the development of the disease. The main pathological changes are diffuse enlargement of the thyroid gland, follicular epithelial cell hyperplasia and lymphocyte infiltration. Clinical manifestations include hypermetabolic syndrome such as hyperphagia, hunger, and fatigue; psychoneurological changes such as anxiety, irritability, insomnia, and hyperactivity; palpitations, shortness of breath, tachycardia, and arrhythmia in the cardiovascular system; and abnormalities of the digestive, muscular, skeletal, hematopoietic, and reproductive systems. The main signs are diffuse enlargement of the thyroid gland and proptosis.
4.7.2 Coronary heart diseaseCoronary heart disease is known as coronary atherosclerotic heart disease. It is common in middle-aged and elderly people with increased total blood cholesterol, triglycerides, low-density lipoprotein (LDL) cholesterol, hyperlipidemia, hypertension, smokers and diabetics. Under the condition of long-term hyperlipidemia, LDL and cholesterol cause functional damage to the arterial endothelium, so that the surface properties of vascular endothelial cells and leukocytes change, and the expression of adhesion factors increases; the number of monocytes adhering to the endothelial cells increases and moves to the subendothelium to become macrophages, which phagocytose oxidatively modified low-density lipoproteins through scavenger receptors to form the atherosclerotic lesions of lipid streaks; At the same time, macrophages oxidize LDL, form peroxides and superoxide anions, and synthesize and secrete six cytokines, including platelet-derived growth factor (PDEF), fibroblast growth factor (FGF), and transforming growth factor β (TGFβ), etc. PDGF and FGF *** Smooth muscle cells and fibroblasts proliferate and migrate to the endothelium, and also *** new connective tissue is formed. PDGF and PDEFβ not only cause smooth muscle cells to migrate into macrophage-rich fat strips and turn into foam cells, but also contribute to the evolution of fat strips into fibro-fatty lesions and the development of fibrous plaques. In addition, hemodynamic changes such as increased blood pressure can interrupt the continuity of endothelial cells in the arterial endothelium, exposing the subendothelial tissue, at this time, platelet-activating factor activates the platelets in the blood, causing them to adhere to the endothelium to form a wall-attached thrombus; the platelets release a number of cytokines, including macrophages, which enter the arterial wall to promote the arterial atherosclerosis; and also found that the arterial atherosclerosis in various stages of the lesions have T lymphocytes. T-lymphocytes were also found in lesions at various stages of atherosclerosis, suggesting that the development of lesions may be related to immune or autoimmune reactions. The main pathological changes are coronary artery vascular stenosis or spasm leading to myocardial ischemia, hypoxia or necrosis, and a series of clinical symptoms, such as myocardial ischemia, angina pectoris, myocardial infarction, ischemic heart disease, and sudden death, with angina pectoris being the most common.
4.7.3 Viral myocarditisThe etiologic mechanism of viral myocarditis is described in the section on Angelica Six Yellow Soup. Rheumatic heart disease is a late complication of group A group B hemolytic streptococcal infection causing pharyngitis. The bacterial cell wall outer protein in the M protein and its related proteins: the middle polysaccharide N acetyl glucosamine and rhamnose are with the human myocardium as well as the plasma protein of the cell membrane and heart valves have *** the same antigenicity, and the human myocardial tissues autoimmune reaction. Firstly, these streptococcal antigens mimic autoantigens and streptococcal antibodies form immune complexes deposited in the myocardium and heart valves, activating complement components to produce inflammatory lesions. Secondly, the cellular immune response is abnormal: ① the proliferative response of peripheral lymphocytes to streptococcal antigens is enhanced, and T-lymphocytes of the affected patients have a cytotoxic effect on cardiomyocytes; ② the peripheral blood has enhanced leukocyte movement inhibition test induced by streptococcal antigens, decreased lymphocytoclastoid cytotropic and proliferative response, and enhanced NK cell function; ③ the immune response of the patient's tonsillar mononuclear cells to the streptococcal antigens is abnormal. The third is that a combination of other toxins of the bacterium and individual genetic background can also produce inflammation in the myocardium and valves. The main pathologic changes are 3 stages: exudation, proliferation and sclerosis. The main clinical manifestations are fever, low heart sound, arrhythmia, and in severe cases, heart failure; valvular lesions can be heard in the valvular region of an abnormal murmur; the occurrence of pericarditis can be pericardial effusion signs.
4.7.4 ArrhythmiasArrhythmias include: (1) abnormal impulse formation, abnormal spontaneous cardiomyocyte excitation in the sinoatrial node, interjunctional fasciculus, atrioventricular node, atrioventricular fasciculus, and Hirschsprung's bundle-Purkinje system, including sinus arrhythmia and ectopic arrhythmia; (2) impulse conduction abnormality, including physiologic, pathologic, and atrioventricular conduction pathway abnormality. These two abnormalities can lead to various forms of arrhythmia. There are many primary causes of arrhythmias, such as myocarditis and coronary artery disease, which are mainly due to electrophysiologic abnormalities of excitability, conduction, and autoregulation of cardiomyocytes in the heart. There are also many types of arrhythmia, all of which are diagnosed by electrocardiogram. The main clinical manifestations are palpitations, precordial discomfort, and in severe cases, syncope and sudden death.
4.8 Pharmacological effects of Scorched Licorice Soup[6]
4.8.1 Effects on immune functionAnimal experiments have proved that the monarch drug Dihuang can counteract the decrease in plasma corticosterone concentration due to continuous administration of dexamethasone, and prevent adrenal cortical atrophy. Its aqueous extract can promote the DNA and protein biosynthesis of ConA-activated lymphocytes, enhance the production of IL2, significantly increase the peripheral blood T-lymphocytes, and enhance the phagocytosis of reticuloendothelial system. The ministerial drug ginseng has a wide range of effects on cellular immunity and humoral immunity, ginsenoside and ginsenoside are the active components of ginseng to regulate the immune function. Ginseng not only has the effect on normal animals, but also has the effect on the animals with low immune function to improve the immune function; ginseng flower saponin can increase the concentration of specific antibody, improve the level of serum IgG, IgA, IgM, and have the effect on the phagocytosis of reticuloendothelial system, and it can promote the lymphocyte reaction of T, B lymphocytes to the schizogen *** caused by the lymphocyte reaction; ginseng saponin can increase the proliferation of the splenic T-cells ConA reaction, promote IL2 production and increase the activity of splenic NK cells; ginseng polysaccharides can promote phagocytosis of reticuloendothelial system, induce THF and anti-complement activity. Glycyrrhiza glabra not only induces interferon and enhances the activity of NK cells, but also glycyrrhizic acid inhibits mast cell degranulation and has an antiallergic effect; glycyrrhizic acid also increases the weight of spleen and thymus, enhances the activity of reticuloendothelial system, increases the antibody in vivo remarkably, and activates the proliferation of lymphocytes; Glycyrrhiza glabra Lx reduces the amount of antigens and acts as an immunosuppressor, and inhibits penicillin-allergic shock; glycyrrhiza glabra polysaccharides increase the activity of the reticuloendothelial system and monocyte phagocytosis; licorice sweeteners can inhibit the release of histamine from mast cells and enhance the ability of ConA-induced lymphocyte secretion of IL2; licorice hypoglycolic acid can elevate the ratio of lymphocytes; glycyrrhetinic acid diamine can increase the level of serum INFα; and β licorice hypoglycolic acid is an inhibitor of the classical pathway of human complement. Jujube can improve the function of mononuclear-phagocytic cells in the body, enhance muscle strength and body weight, promote hemolysin and hemolytic vacuoles, promote the transformation of lymphocytes, improve the decomposition of peripheral blood lymphocytes, and promote macrophage secretion of THFα, IL1, and NO, and have obvious anti-complement activity. Colla Corii Asini can promote the transformation of lymphocytes in healthy people; improve macrophage phagocytosis percentage and phagocytic index; it has a promoting effect on NK cells; it can counteract cellular immunosuppression caused by hydrocortisone; at the same time, Colla Corii Asini also has the effects of anti-fatigue, anti-radiation, and improving the ability of cold tolerance. Ophiopogon can enhance the phagocytosis of reticuloendothelial system, antagonize the reduction of WBC induced by cyclophosphamide and 60Co irradiation, elevate peripheral leukocytes, *** serum lysin production, improve the immune function, enhance the role of pituitary-adrenocortical system, and improve the adaptability of the organism. The adjuvant cinnamon sticks, on the other hand, has a strong anti-allergic effect. Ginger alters immune function, elevates organ index, and increases macrophage phagocytosis.
4.8.2 Effects on heart, blood vessels, blood rheologyThe Chinese medicinal drug Dihuang has cardiotonic effects, especially on the failing heart, and has diuretic and antihypertensive effects, and its antihypertensive effects are related to the elevation of cAMP by Dihuang, which decreases the cGMP/cAMP ratio. Ginseng can enhance the release of catecholamines, inhibit myocardial cell membrane Na+K+ATPase activity, so that Na+Ca2+ exchange increased, so there is a strong cardiac glycoside-like effect, can enhance myocardial contractility, increase cardiac output, so that the coronary blood flow increases, heart rate slows down, and there is an anti-arrhythmic effect; ginseng has an anti-hypoxia and myocardial protection effect, mainly with ginseng can reduce myocardial oxygen consumption and increase coronary blood flow Ginseng saponin can reduce the scope of myocardial infarction, inhibit the activity of creatine phosphokinase in plasma and reduce the ratio of PGI2/TXA2; ginseng saponin has a dose-dependent inhibitory effect on fibrinase-induced conversion of fibrinogen to fibrin; ginseng saponin has a dose-dependent inhibitory effect on conversion of fibrinogen to fibrin; ginseng saponin can reduce the scope of myocardial infarction; ginseng saponin can increase the blood flow of coronary artery and decrease myocardial oxygen consumption. Ginsenoside can significantly reduce whole blood viscosity and inhibit platelet aggregation at the same time; ginsenoside has inhibitory effect on platelet aggregation induced by ADP, thrombin, and arachidonic acid by blocking the metabolism of PG and the antagonism of Ca2+; ginsenosides Rg3 and Rg1 are the main components of platelet aggregation inhibition, so ginsenosides have the effect of inhibition of thrombus formation. Glycyrrhiza glabra has anti-atherosclerotic effect, glycyrrhizic acid has the effect of inhibiting the activity of phospholipase A2 and platelet aggregation; glycyrrhiza glabra flavonoids have the effect of antiarrhythmia; glycyrrhiza glabra hypoglycolic acid can reduce the scope of myocardial infarction, and has the agonist-like effect of angiotensin II A1 receptor. Glycyrrhiza glabra can restore the very low level of blood pressure to the normal level, and the effect is more lasting; for endotoxin shock Glycyrrhiza glabra can make the total resistance of the body circulation decrease, make the relative viscosity of whole blood and plasma viscosity decreased significantly, make the microcirculation obstacles reduce or return to normal, so that Glycyrrhiza glabra has an anti-shock effect. Maitake can significantly improve myocardial contractility and heart pumping function, increase coronary blood flow and cardiac output, and has the effect of anti-arrhythmia, can reverse the inhibition of cardiac function in hemorrhagic shock, improve the circulation, so that the blood pressure back to normal, with an anti-shock effect; Maitake increases the myocardial nutritive blood flow after infarction, narrowing the scope of myocardial infarction, and can make the cardiac myocytes that have been significantly victimized (post-infarction) to get repaired more quickly. The ethanol extract of hemp kernel has hypotensive and hypolipidemic effects. The adjuvant cinnamon sticks can dilate blood vessels, improve peripheral circulation, increase coronary blood flow, increase trophic blood flow, improve myocardial ischemia and reperfusion myocardial function, improve myocardial SOD activity, and reduce the content of LPO; cinnamon sticks contain cinnamaldehyde can inhibit platelet aggregation, and have antithrombin effect. Ginger can excite vasomotor center and heart; ginger contains 6 gingerol, 8 gingerol, 10 gingerol are cardiotonic drugs, can increase myocardial contractility; ginger on blood pressure can produce a transient lowering of blood pressure, obvious pressure and persistent lowering of three-phase effect; ginger can affect the AA metabolism in the platelet, inhibit the synthesis of TXB2 and PGs, and has the effect of anti-platelet aggregation.
According to the above two therapeutic mechanisms, the formula should have therapeutic effects on rheumatic myocarditis, viral myocarditis, and arrhythmia.
4.8.3 Effects on the function of the nervous and endocrine systemsDihuang can significantly enhance the hypnotic effect of subthreshold dose of sodium pentobarbital, thus exerting a sedative effect. Dioscorea opposes the decrease of corticosterone concentration caused by dexamethasone and prevents adrenal cortex atrophy; it antagonizes the hypopituitarism caused by glucocorticoid; Dioscorea treats hyperthyroidism, increases the maximum binding capacity of renal β-receptor to normalize, and decreases T3 and T4. Ginseng can excite pituitary-adrenocortical system, promote the secretion of corticosteroid by adrenal cortex, and also excite hypothalamic-pituitary-gonadal axis, promote the release of sex hormone, synthesis and the development of sex organs, *** insulin secretion; improve the ability of the body's stress response, promote the function of the thyroid gland, improve the ability of resistance to hypoxia, and enhance the adaptive capacity of the body, which has the function of Anti-fatigue, anti-stress, anti-mutagenic, anti-aging effects, and can *** low physiological functions; ginseng pharmacological activity due to the different states of the body and biphasic effect, this adaptation to the original role is conducive to the recovery of the body. Ginseng can expand cerebral blood vessels, increase cerebral blood flow, improve cerebral oxygen supply and energy metabolism, promote RNA and protein synthesis in brain, promote cerebral neuronal development, increase brain weight and cerebral cortex thickness, increase the number of synapses in the upper layer of pyramidal cells of hippocampal CA3 area, and improve the function of hippocampal neurons; protect neuronal cells, reduce the death rate of neuronal cells, and promote the synthesis and release of neurotransmitters in the brain, and increase the synthesis and release of DA and NA. Increase the content of DA and NA in the brain, therefore, it can promote the function of brain learning and memory, and have a regulatory effect on the excitation and inhibition of the central nervous system, through the excitation of the cortex of the brain, so that the excitation and inhibition process can be balanced, so that the nervous disorders of the neural activities can be restored to normal, to improve the flexibility of the neural activities, and to improve the efficiency of brain work. Total flavonoids contained in licorice have protective effect on cerebral ischemia-reperfusion damage, glycyrrhizic acid can improve ischemia-reperfusion brain mitochondrial ATPase, brain tissue lactase dehydrogenase activity, reduce cerebral edema; licorice FM100 has sedative, analgesic, anticonvulsant effect; it can stimulate hypothalamo-pituitary-adrenocortical axis and produce corticotrophin-like It can stimulate the hypothalamic-pituitary-adrenal cortex axis and produce corticosteroid-like effect, and improve the endocrine regulation of the body. Jujube has hypnotic and sedative effects, and jujube polysaccharide can reduce brain aging. Maitake has the effect of enhancing the function of pituitary-adrenocortical system and improving the adaptability of the organism; at the same time, Maitake decoction also has sedative effect and has synergistic effect with chlorpromazine and pentobarbital sodium; Maitake can significantly reduce blood sugar. Ma Ren has analgesic effect. The adjuvant cinnamon sticks decoction has antipyretic and analgesic effects, and cinnamon bark aldehyde has sedative and anticonvulsant effects. Ginger also has the above effects of cinnamon sticks. The excitatory effect of ginseng, maitake and licorice on the pituitary-adrenocortical system inevitably increases the secretion of corticosteroid in the body, which strongly exerts anti-inflammatory, antipyretic and promotes substance metabolism and water-salt metabolism, especially the "permissive" effect of glucocorticoid, which can coordinate the role of other hormones, thus making the state of recovery in the body. Glucocorticoids can coordinate other hormones in the body to play a role in restoring the balance of the body state.
Human Body Surface Area Calculator BMI Index Calculation and Evaluation Female Safe Period Calculator Due Date Calculator Normal Pregnancy Weight Gain Pregnancy Medication Safety Classification (FDA) Five Elements and Eight Characteristics Adult Blood Pressure Evaluation Body Temperature Level Evaluation Diabetes Dietary Advice Clinical Biochemistry Common Unit Conversion Basal Metabolic Rate Calculator Sodium Replacement Calculator Iron Replacement Calculator A quick reference to the commonly used Latin abbreviations for prescriptions Commonly Used Symbols for Pharmacokinetics Quick Look Effective Plasma Osmolality Calculator Ethanol Intake CalculatorMedical Encyclopedia, Calculate Now!
4.8.4 Effects on hematopoiesis and cellular functionThe Chinese medicinal drug Radix Rehmanniae Praeparata can accelerate the proliferation and differentiation of bone marrow red lineage hematopoietic progenitor cells (CFUE) and pluripotent hematopoietic stem cells (CFUS), and it has a significant effect on hematopoiesis; ginseng can promote the synthesis of DNA, RNA, proteins, and fats in the bone marrow, promote the mitotic division of bone marrow cells, and *** bone marrow hematopoietic function. Ginsenoside R0 and ginsenoside have obvious promotion effect on bone marrow potential stem cells, which is mainly manifested in promoting the differentiation of erythrocytes and the formation of mixed colonies composed of erythroid, granulocyte and megakaryocyte; meanwhile, ginsenoside promotes the secretion of hematopoietic factors such as GHCSF, hematopoietic factors IL3 and IL6 by lymphocytes and bone marrow stromal cells; ginsenoside diol extract can increase the rate of iron intake of hemolytic rabbits, and increase the rate of iron loss in hemolytic rabbits, and increase the rate of iron loss in hemolytic rabbits. Ginseng diol extract can increase the rate of iron uptake in hemolyzed rabbits and increase the uptake of radioactive iron in the liver of hemorrhagic rabbits. Jujube is rich in vitamins, amino acids, sugar and trace elements, providing sufficient raw materials for the body's hematopoiesis. Jujube and licorice have certain therapeutic effects on anemia, and their immune promotion and adjustment effects are also in the pathogenesis of many kinds of anemia. Colla Corii Asini has a powerful effect of tonifying blood and generating blood, and the collagen contained therein has a beneficial effect on hematopoietic stem cells; the glycosaminoglycans contained therein have a close relationship with the cell proliferation and the organization differentiation of the hematopoietic system, which not only can make the hemoglobin, reticulocytes and red blood cells increase significantly but also can make the total number of leukocytes and platelets increase significantly; glycine contained in Colla Corii Asini can promote the absorption of calcium, and has the effect of calcium balance; Colla Corii Asini contains muscle composition, which can promote calcium absorption, and has the effect of calcium balance. The role of; Colla Corii Asini contains muscle components and a variety of amino acids, can promote muscle cell regeneration, and the formation of normal muscle fibers.
4.8.5 Antioxidant and anti-aging effectsRadix et Rhizoma Ginseng can enhance the activity of glutathione peroxidase (GSHPx) in blood and reduce the content of lipid peroxide (LPO), thus it has anti-aging effects. Ginseng contains a variety of antioxidant substances, which can also regulate physiological functions such as nerve, endocrine, immune function and material metabolism; ginseng maltol, salicylic acid and vanillic acid have obvious antioxidant effects, and maltol can also capture free radicals and reduce the sulfhydryl groups of membrane protein molecules from being exposed, thus stabilizing the structure of membrane proteins; ginseng polyacetylene has an inhibitory effect on the reaction of lipid peroxidation of microsomes; ginseng root, stem and leaf saponins all can Enhance the activity of SOD and CAT, and reduce the content of lipid peroxides; ginsenosides can inhibit the damage of free radicals on vascular endothelial cells, and antioxidant radicals on myocardium; ginsenosides can increase the activity of SOD, and inhibit cerebral damage caused by cerebral ischemia and post ischemic reperfusion; ginseng has an antistress effect, and it can increase the ability of tolerance to hypoxia, low temperature, and high temperature, and increase the ability of tolerance to heat stress, noise stress, light stress, and heat stress. Ginseng has anti-stress effects, and can increase tolerance to hypoxia, low temperature and high temperature, and has positive effects on heat stress, noise stress and light stress; ginseng root, fruit, stem and leaf saponins can promote the proliferation of lung fibroblasts of the aged human embryo, and can make the "non-dividing" cells in the senescent cell population to be transformed into "dividing" cells and shorten the cell division cycle; ginseng saponins can also promote the growth of RNA, and can also promote the development of RNA and RNA. Ginsenoside can also promote the synthesis of RNA, DNA and protein, and has the protective and *** effect on the hematopoietic function of bone marrow, increase the number of peripheral blood cells, promote the synthesis of DNA, RNA, protein and fat of bone marrow, promote the mitosis of bone marrow cells and *** hematopoietic function of bone marrow. Licorice has the effect of detoxification of all kinds of drugs, food poisoning, metabolite poisoning, bacterial toxins and pesticide poisoning, etc. It has certain detoxification effect; licorice has the effect of scavenging free radicals and antioxidant. The main component of jujube, jujube polysaccharide, can improve blood SOD, CAT vitality, reduce the brain, liver, plasma LPO content, scavenging free radicals, especially strong scavenging of reactive oxygen radicals, is the main ingredient to slow down aging; jujube is rich in proteins, sugars, organic acids and a large number of vitamins, trace elements, but also has an anti-aging effect. Colla Corii Asini has the effect of anti-radiation, anti-fatigue, and improving cold tolerance. Ophiopogon has the effect of anti-lipid peroxidation and anti-hypoxia, and has an extremely strong scavenging effect on reactive oxygen radicals, inhibits the activity of monoamine oxidase in the brain, and improves the activity of plasma, liver, SOD, and the total antioxidant capacity, and significantly reduces the content of MDA. Gui Zhi can inhibit histamine production, inhibit PG synthesis and release, inhibit complement activity, scavenging free radicals, with anti-inflammatory and antioxidant effects. Ginger extract can remove superoxide anion and hydroxyl radical, inhibit hemolysis caused by H2O2, inhibit hepatic MDA production and lipid peroxidation.6. Antipathogenic microorganisms and anti-inflammatory effects
The monocotyledonous drug Radix et Rhizoma Sanguisorbae has bacteriostatic effects on a variety of fungi such as tinea pedis and tinea castanea. Licorice extract and sodium glycyrrhizinate have inhibitory effect on Staphylococcus aureus, Mycobacterium tuberculosis, Helicobacter pylori, Escherichia coli, amoeba and trichomonas; glycyrrhizic acid compounds have broad-spectrum antiviral effects through the direct action of various viral particles and the indirect action of inducing interferon, increasing the activity of NK cells and macrophages to activate the immune functions of the hosts, especially on HIV, herpes simplex virus and varicella-zoster virus. Especially for HIV, herpes simplex virus and varicella-zoster virus, the efficacy is certain. Glycyrrhiza glabra polysaccharide can inhibit herpes simplex virus, vesicular stomatitis virus and cowpox virus; glycyrrhizic acid can inhibit adenovirus, coxsackievirus and syncytial virus; glycyrrhiza glabra sweeteners can inhibit hepatitis virus in addition to the above mentioned viruses; glycyrrhiza glabra monoamine can inhibit HIV; maitake saponin, maitake decoction and maitake powder can have an inhibitory effect on Staphylococcus albicans, Bacterium subtilis, Escherichia coli and typhoid fever bacteria. In addition to the strong inhibitory effect on the above bacteria, the adjuvant cinnamon sticks also have strong inhibitory effect on common skin fungi, as well as on Bacillus anthracis, Vibrio cholerae, Salmonella, and dysentery bacillus; cinnamon bark aldehyde inhibits Mycobacterium tuberculosis, and cinnamon sticks decoction also inhibits influenza virus and orphan viruses. Ginger water infusion has a significant inhibitory effect on typhoid bacillus, Vibrio cholerae, salmonella, staphylococcus, streptococcus and streptococcus pneumoniae; its alcoholic extract also has an inhibitory effect on Staphylococcus aureus, Staphylococcus albicans, Pseudomonas aeruginosa, and dysentery bacillus. At the same time on the common skin fungi also has an inhibitory effect.
4.9 SongsScorched Licorice Tang Di Mai Shen, Gui Gao Jiang Zao Wine Ma Ren; pulse knot generation Ruoxi heart palpitations, deficiency labor lung impotence qi and blood poverty.
5.3 IndicationsScorched Licorice Soup of the formula in Volume 17 of Rhinoceros Candles on the Origin and Flow of Miscellaneous Diseases is used for treating heat-jacking and dryness diseases, and the fainting of evils in time.
5.4 NotesGinseng in this formula is called "Western ginseng" in the "Complementary Essentials of Medicine".
5.5 Provenance