A few patients may have allergic reactions, with small papules and itching all over the body, and the rash may disappear1~ 2 days after drug withdrawal. However, after taking the Eupolyphaga sinensis preparation again, the same skin lesion reaction will occur, which may be caused by the stimulation of the foreign protein contained in it. It has certain irritation to digestive tract, and there are also reports of sinus heart rate slowdown caused by the therapeutic dose of this product. Those who have allergic reactions and other side effects can be treated with chlorpheniramine and vitamin C.