1. Pregnant and lactating women: During pregnancy and lactation, using saffron in water will affect the development and health of the fetus or baby.

2. Patients with hypotension: Saffron has the effect of lowering blood pressure, so people with hypotension need to be careful when drinking saffron water to avoid physical discomfort caused by low blood pressure.

3. People with allergies: Some people have allergic reactions to saffron, including skin allergies, difficulty breathing, dizziness, etc.

4. Patients under medical treatment: Some drugs will have adverse reactions or interactions with saffron, so patients under treatment should use saffron soaked in water with caution under the guidance of a doctor.