What causes cyanide poisoning?
Occupational cyanide poisoning is mainly through the respiratory tract, and can also be absorbed through the skin at high concentrations. Life cyanide poisoning is mainly oral. Oral mucosa and digestive tract can be fully absorbed. After cyanide enters the human body, cyanide ions are separated and combined with trivalent iron of cytochrome oxidase oxidized in cell mitochondria, which prevents the reduction of trivalent iron in oxidase, hinders the normal breathing of cells, causes tissue hypoxia, and makes the body fall into an internal suffocation state. In addition, the molecules of some nitrile compounds themselves have a direct inhibitory effect on the central nervous system. Detoxification measures: sodium nitrite thiosulfate therapy: firstly, sodium nitrite and isoamyl nitrite are used to quickly generate methemoglobin. Methemoglobin can replace cytochrome oxidase in cyanide cytochrome oxidase, thus restoring its activity. The residual CN- was washed with sodium thiosulfate to generate nontoxic thiocyanate and excreted. Dimethyl methylene blue (methylene blue): low dose methylene blue can be used for methemoglobinemia; High-dose methylene blue can be used for the first aid of cyanide poisoning. The lethal dose of sodium cyanide is 150 ~ 250 mg (if adults take bitter almond 40 ~ 60g orally, it will cause poisoning or death).