("Don't record")

Black twist with different names (Qian Jin Fang).

The source is the male flower branch of Moraceae plant hemp. See article "Hemp Seed" for plant morphology.

The resin secreted by the female flower spike contains narcotic substances such as cannabinol, tetrahydrocannabinol and cannabidiol, among which tetrahydrocannabinol has the strongest activity, cannabidiol takes the second place and cannabinol is the smallest. Cannabis resin also contains cannabidiol acid, cannabinol and trans cinnamic acid; In addition, the resin also contains choline, fenugreek alkali and muscarinic acid; It also contains amino acids such as arginine and histidine.

Steam distillation of Rhizoma Twist obtained about 0.5% of volatile oil, which contained eugenol, α-pinene, β-pinene, camphene, α-terpinene, γ-terpinene, β-phellandrene, linalool, oxidation trans-linalool, cedrene and α.

In addition, it contains piperidine, which is a malodorous substance. Wild cannabis is particularly malodorous, that is, it contains more piperidine.

Twist still contains antibacterial components, see "hemp leaves".

Pharmacological action ① Effect on central nervous system

Cannabis or hashish (mainly female flower spikes and a small amount of fruits, leaflets and slender stems) has a special influence on people's mental state. The effect on the central nervous system may vary according to the dosage, route of administration and the special environment when taking drugs, especially it has a great relationship with personality. After taking drugs, people may feel excited, feel euphoric, or indulge in depression and panic. Large doses often produce hallucinations, and long-term use will lead to mental degradation and serious loss of work ability. These effects are mainly caused by tetrahydrocannabinol, which can be tolerated for a long time, even at a dose greater than the lethal dose, and there is no withdrawal phenomenon when stopping the drug. It takes a large dose to produce the same effect as inhalation, and the effect occurs slowly, which may be caused by the destruction of effective components by digestive juice or part of them when passing through the liver. The effect of Δ9-THC on the central nervous system of animals is both exciting and inhibiting, and the spontaneous activity of animals is inhibited. However, when it is given to the outside world, its response is more sensitive, and it can prolong the sleep time of barbiturates, but it also has a synergistic effect on the increase of spontaneous activity caused by amphetamine. Intraperitoneal injection in mice has obvious anti-injury (analgesic) effect (hot plate method).

② Antibacterial effect

Hemp produced in Europe has antibacterial effect, and its effective components are acidic amorphous substances with phenolic or carboxyl groups, which are insoluble in water but soluble in solvents such as ether and petroleum ether. 1:150000 can inhibit mycobacterium tuberculosis, but it has no effect on gram-negative Escherichia coli, Pseudomonas aeruginosa and Proteus. Whole blood, plasma and serum can partially inactivate this component and reduce its antibacterial efficacy. For Staphylococcus aureus, when the concentration of this component is1:100, it can be killed immediately; 1:10000 takes 8 hours. Clinically, it can be used for disinfection of oral cavity, otorhinolaryngology and skin.

The lethal dose of toxicity to mice is (mg/kg): 42.5 (intravenous injection), 455 (intraperitoneal injection) and 482 (intragastric administration); The median lethal doses to rats were 28.6, 373 and 666 respectively. The symptoms of poisoning are dyskinesia and hyperreflexia, followed by inhibition, disappearance of righting reflex, dyspnea and even death. After death, the autopsy showed pulmonary congestion and edema, and no obvious abnormality was found in other organs.

Bitter and pungent in nature, warm and toxic.

① Wupu Materia Medica: "Lei Gong: pungent, non-toxic."

② Theory of Medicinal Properties: "Bitter in taste, slightly hot and nontoxic."

Functions are mainly used to dispel wind and promote blood circulation. Treating wind disease, numbness of limbs, itching all over, and amenorrhea of women.

(1) The Theory of Medicinal Properties: "Treating itching all over the body, expelling wind and evil blood, the main woman can't get through the waiting."

② "Compendium": "Treating forgetfulness and abscess with internal leakage."

It is advisable to avoid ① Wupu Materia Medica: "Fear of oysters."

(2) The Theory of Medicinal Properties: "Insects are used as a tool."

Prescription 1: Treatment of numbness due to wind disease: four or two pieces of twist, one or two pieces of kusnezoff monkshood root, stir-frying, which is the end, refined honey and mixed into paste, three points for each serving, and mixed with white soup. (Compendium)

(2) Treatment of scrofula: Divide Rhizoma Mahuae and Folium Artemisiae Argyi equally, mash them together and make a wok. Moxibustion is a hundred strong. (Qian Jin Fang)

Remind you: this Chinese herbal medicine, Twist, comes from the Internet. Please follow the doctor's advice before using it.