The improper selection of planting site environmental conditions (temperature, humidity, soil, light) determines the yield and artemisinin content of Artemisia annua, and different regions have a great influence on the yield and artemisinin content of Artemisia annua [7-9], and different environments in the same region also have a great influence on the yield and artemisinin content of Artemisia annua. Artemisia annua is a masculine plant with high light requirements and should not be planted under shaded conditions. For example, many growers planted Artemisia annua in orchards or interplanted with corn, which resulted in poor growth of Artemisia annua and extremely low yield. On the other hand, Artemisia annua seeding period and seedling period on the water requirements are also higher, without sufficient water will lead to low germination rate or seedling after the death of drought; groundwater level is too high or poor drainage, will make Artemisia annua disease increase, the emergence of root rot and stem rot, and gradually die. 2005 in xiangzhou county of guangxi transplant planting of artemisia annua, there are 2 ha of artemisia annua due to the groundwater level is too high or drainage caused by the death of the bad.

Improper planting method adopts different planting methods related to the success of artificial cultivation. According to the survey, there are 4 ways of direct sowing, strip sowing, spot sowing, and seedling transplanting in large-scale cultivation. 200 ha of seeds were directly sown in Lujai County, Guangxi, from February to March, 2006, with the germination rate of less than 5% and the seedling rate of less than 1%; 60 ha of seeds were directly sown in spot sowing by mixing seeds with sugarcane ash, with the germination rate of about 50% and the seedling rate of less than 2%; and from February to April, 2006 in Du'an, Guangxi, the germination rate of Artemisia annua was less than 1%, and the seedling rate of less than 2% was less than 2%, Dahua and Jingxi counties in Guangxi from February to April 2006, the seeds were directly sown in strips and spots for 600 ha, and the germination rate was about 40%, with a seedling success rate of less than 15%. Therefore, in artificial cultivation, seeds cannot be sown directly in the field unless their environmental conditions (temperature and humidity) are suitable for seed germination and growth, otherwise they will fail.

Seedling confusion in recent years, due to the rising prices of raw materials of Artemisia annua, many people blindly planted, indiscriminate harvesting of wild seed cultivation, the emergence of planted varieties of mixed, good and bad, the production of raw materials of artemisinin content of artemisin less than 0.6% or more, the manufacturer does not purchase, resulting in economic losses.

Sowing too late and harvesting too early in Guangxi, although Artemisia annua from the harvest to mid-May of the following year can be sown, but mid-February to mid-March is the best time to sow Artemisia annua. Some growers only sow seeds after April, due to the short growing period, directly affecting the yield and quality of Artemisia annua. On the other hand, due to the shortage of raw materials of Artemisia annua, many intermediaries for the purchase of raw materials, July began to buy raw materials of Artemisia annua, Artemisia annua in the low content of artemisinin, reduce the production capacity of artemisinin and improve the cost of production, a direct impact on the development of artemisinin processing industry.

Neglect of water and fertilizer management Artemisia annua is widely distributed in Asia's temperate, cold temperate and subtropical regions, at an altitude of 300 m below the rocky mountains, soil slopes, hills, flatlands, roadsides and houses in front of the red soil, red and yellow soil, limestone soil, etc. are distributed, and can grow and develop normally. Many people therefore think that Artemisia annua can grow everywhere, strong adaptability, no fertilizer management. Due to the lack of fertilizer management, the growth of Artemisia annua is extremely poor, the yield is very low.

Continuous cultivation, serious pests and diseases Artemisia annua has fewer pests and diseases, but continuous cultivation can make the problem of pests and diseases will gradually intensify. Generally, when Artemisia annua is planted in the first year of new land, there are few pests and diseases; however, after the continuous cultivation, there will be root and stem rot, tigress, aphids, small cabbage moths, ruler vipers and other pests and diseases, and the rate of disease damage is 3% to 5%. The damage rate of insect pests such as aphids, small cabbage moths and ruler vipers is 10% to 30%.