1, patients with yin deficiency. Coix seed is wet, which will damage yin and body fluid. Patients with yin deficiency who take too much coix seed will aggravate yin deficiency (manifested as dry mouth and thirst, which can't quench their thirst, and in severe cases, they are upset, hot flashes and night sweats).

2. Patients with deficiency-cold syndrome, especially those with severe deficiency of kidney yang. Coix seed is cold, clearing away heat and promoting diuresis, and taking too much of it will hurt the yang, which will aggravate the condition (fear of cold, obvious fear of cold in feet, lower limbs and waist, fatigue, laziness, impotence and premature ejaculation in men, infertility in women due to palace cold).