Chinese name: leptin; Clenbuterol; Clenbuterol hydrochloride; Diclofenac hydrochloride; Clenbuterol; Ammonia croup; Amphetamine; Amphetamine; Ammonia Diclofenac; Ammonia Diclofenac amine English name: Clenbuterol; Spiropent; Planipart; NAB365; 4-Amino-3,5-dichloro-alpha-((1,1-) dimethylethyl)amino)methyl)benzenemethanol; CAS No.: 37148-27-37-63 dimethylethyl)amino)methyl)benzenemethanol; CAS No.: 37148-27-9 Molecular Formula: C12-H18-Cl2-N2-O Physical and Chemical Characteristics White or off-white crystalline powder, odorless, bitter taste, melting point 161 ° C, soluble in water, ethanol, slightly soluble in acetone, insoluble in ether. Usage Leptin is a kind of β2-agonist, which was used as feed additives in foreign countries in the early 90's, and then banned due to the adverse reactions of human beings. In spite of the regulations of the Ministry of Agriculture, domestic pig farmers mixed leptin into the feed in order to make pork not to grow fat. After the pigs consume it, it promotes protein synthesis and accelerates fat conversion and decomposition in the metabolic process, which improves the leanness of pork, so it is called leptin. Toxicological profile Clenbuterol can agonize β2-receptors, has an excitatory effect on the heart, and has a strong and long-lasting dilatation effect on bronchial smooth muscle. It is easily absorbed through the gastrointestinal tract after oral administration. As asthma medication orally adults 20-40μg / times, 3 times / day; children over 5 years old 5-20μg / times, 3 times / day. Human (female) oral TDLo: 4600 ng/kg. Mouse venous LD50: 27600 ug/kg. Clinical manifestations 1. Acute poisoning with palpitations, face, neck and limb muscle tremors, hand tremors or even inability to stand, dizziness, fatigue, patients with pre-existing arrhythmia are more prone to react, tachycardia, premature ventricular contractions, electrocardiogram shows S-T segment depression and T-wave inversion. 2. Patients with pre-existing sympathetic hyperfunction, such as hypertension, coronary artery disease, hyperthyroidism, the above symptoms are more likely to occur. 3. Combination with glucocorticoids may cause hypokalemia, which may lead to arrhythmia. 4. Repeated use will produce tolerance, weakening and shortening the duration of bronchodilator effect. Although the residual toxic effects of clenbuterol are mild, FDA studies have shown that people who apply sympathomimetics or are allergic to the former drug react more severely to clenbuterol than normal healthy individuals.