Ligustrazine rhizome contains ligustrazine (tetramethylpyrazine), ryegrass alkali or ligustrazine (1-(5- hydroxymethyl -2- furyl) -9h- pyrido [3,4-b] indole [1-(5- hydroxymethyl -2- furyl) -9h-. 3- butyl -7- hydroxyphthalimide, butylphthalide, (3S)-3- n-butyl -4- hydroxyphthalimide [(3S)-3- butyl -4- hydroxyphthalimide] that is, (3S). 3- n-butyl-3,6,7-trihydroxy-4,5,6,7-tetrahydrophthalide (3- n-butyl-3,6,7-trihydroxy-4,5,6,7-tetrahydrophthalide), and trimethoprim Park Jung Su. Chuanxiong lactone) B, C, D, E, F, G, H[ namely cis-6,7-dihydroxy ligustilide], I[ namely trans-6,7-hydroxy ligustilide]. 7- dihydro-ylide)], j, k, l, m, n, o, p, (E)- senkgolide [(E)- senkgolide ]E, senkgolide, 2- methoxy -4-(3- methoxy-1- propenyl. 5- hydroxymethyl -6- endo -3- methoxy -4 1)- octyl -3- one], 4- hydroxy -3- methoxystyrene, 1- hydroxy-1-(3- methoxy -4- hydroxyphenyl 4- hydroxybenzoic acid (4 caffeic acid, protocatechuic acid, ferulic acid, chrysophanol, sedanonic acid, L- isoleucine -L- valine anhydride (L choline chloride, palmitic acid, vanillin, 1- acyl-β-carboline (1- acetyl-β-carboline)) Linoleic acid, dioleoyl palmitoyl glyceride and sucrose.