pharmacological action
1. Hemostasis: the crude extract can promote blood coagulation, and the frog leg can contract the surrounding blood vessels when perfused. After intravenous injection of agrimony in mice, the bleeding time was shortened by 45%. Intravenous injection in rabbits can greatly shorten the clotting time and increase the number of platelets. When experimental femoral artery bleeding occurs in dogs, the local application of Agrimonia pilosa powder and compression has a certain hemostatic effect. However, there are also reports to the contrary that the infusion can neither constrict blood vessels nor promote blood coagulation. The application of agrimony in 1 1 hemophilia patients only had a good effect on the production of plasma thromboplastin in 3 cases. There is no selective effect on the deficiency of factors VIII, IX and X. The hemostatic effect and clinical efficacy of systemic application need further study.
2. Effects on cardiovascular system and smooth muscle: It was found in the early years that its alcohol extract could increase blood pressure in anesthetized animals, which might be caused by cardiotonic and peripheral vascular contraction. The application of alcohol extract of water extract could decrease blood pressure in rabbits; When rabbit ears and frog hind limbs were perfused, low concentration made them contract, while high concentration made them expand, which inhibited frog hearts in vitro. The concentration of1:100000-1:5000 can increase the contraction amplitude of isolated rabbit heart, and the degree of increase is proportional to the concentration. Intravenous injection of 4 mg in normal rabbits did not affect their electrocardiogram. The ethanol extract of water extract excited the isolated intestinal tract of rabbits and guinea pigs at low concentration, but inhibited it at high concentration. The lipid in Agrimonia pilosa can reduce the contraction amplitude and tension of isolated rabbit intestine, stop the intestinal movement in a relaxed state, and also inhibit the intestinal peristalsis of mice in vivo.
3. Anti-inflammatory effect: Water extract, alcohol extract and water extract all have anti-inflammatory effect on rabbit conjunctivitis caused by mustard oil or staphylococcal infection. The alcohol extract and water extract of the former have better anti-inflammatory effect, while the water extract has better anti-inflammatory effect on the latter. In vitro tests show that the water extract has stronger inhibitory effect on staphylococcal infection. Its anti-inflammatory effect lies in the convergence of tannins which can generate condensed tannins in Agrimonia pilosa.
4. Antibacterial and antiparasitic effects: Hot water or ethanol immersion liquid has certain inhibitory effect on Bacillus subtilis and Staphylococcus aureus, and has weak inhibitory effect on human tuberculosis. It has killing effect on paramecium, and the effective components are soluble in ether and chloroform. The underground winter buds of Agrimonia pilosa can repel tapeworms. In vitro experiments show that its main function lies in the cephalic segment, which can inhibit the movement of the sucker and the apical process on the cephalic segment for 4 ~ 7 minutes, making it lose its mobility quickly; After 10-12 minutes, the neck and body segments also stopped moving. The clinical efficacy is consistent with the results of in vitro tests. In addition, Dongya powder has a cathartic effect, so it is not necessary to take laxatives in clinical application. The local application of the tender stem and leaf decoction of Agrimonia pilosa also has a good effect on trichomoniasis. The water extract of agrimony produced in Europe has inhibitory effect on mycobacterium tuberculosis in vitro, and it is also effective for those who have been resistant to streptomycin and p-aminosalicylic acid, but not for those who have been resistant to isoniazid. Ethanol extract has antiviral effect in mice.
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Tropism of nature and taste
The taste is bitter, astringent, slightly sweet and flat.
Meridian entering the lung, liver, spleen and large intestine.
Efficacy indication
1. astringe and stop bleeding: Agrimonia pilosa is bitter, enters the lung and liver meridians, can astringe and stop bleeding, and its nature is even and unbiased, so it can be used for both cold and hot bleeding.
2. Tonifying deficiency and stopping dysentery: Herba et Gemma Agrimoniae is slightly sweet, tonic, and enters the lung, liver and spleen meridians, which can not only replenish qi, but also replenish blood, and dry and wet because of bitter taste, enter the large intestine meridian, and stop dysentery except damp heat in the large intestine. Therefore, it has the effect of tonifying deficiency and stopping dysentery. Commonly used for dysentery and other syndromes.
3. Insecticidal and detoxicating: Agrimonia pilosa tastes bitter and slightly sweet, which can kill insects and detoxify, so it can kill insects and detoxify, and is often used for symptoms such as itching, sores and tinea.
4. Stop malaria: "Guizhou folk prescription medicine collection" contains: Agrimonia pilosa: "Treat malaria, attack every day, chest and abdomen are full". If exogenous malaria pathogen, malaria pathogen and defensive qi are combined, and the pathogen is contending with each other, and the yin and yang are shifted, it will cause malaria attack, with symptoms of chills and intense heat, headache, sweating, fullness in the chest, nausea and vomiting, polydipsia, constipation, red urine, red tongue, thin white or yellow fur, and rapid pulse. Agrimonia pilosa can be used to detoxify malaria.
5. Promoting blood circulation and reducing swelling: The Hundred Herbs Mirror says: Agrimonia pilosa "purges qi and promotes blood circulation to treat all diseases". "Compendium of Materia Medica" contains: Herba et Gemma Agrimoniae "cures swelling and carbuncle, lung carbuncle, breast carbuncle and hemorrhoid swelling". Therefore, this product has the effect of promoting blood circulation and reducing swelling. Commonly used for carbuncle, breast carbuncle and other syndromes.
6。 Identification application
① Bletilla striata, Agrimonia pilosa and Callicarpa formosana are astringent hemostatic drugs. However, Bletilla striata has the strongest astringency and the best hemostasis effect, followed by Agrimonia pilosa and Callicarpa formosana, and its heat-releasing and detoxification effects are stronger than Callicarpa pilosa, Bletilla striata and Hairdressing pilosa.
② Both Agrimonia pilosa and Eclipta prostrata are hemostatic drugs, but Agrimonia pilosa is used to stop astringency and Eclipta prostrata is used to cool blood and stop bleeding.
dosage
Oral administration:10-15g; Large dose of 80-60 grams, decoction, juice or powder. External use: proper amount of tamping.
Compatibility should be avoided
And proper taboos.
Non-bleeding, excessive, not available.
Compatibility application
1. Colla Corii Asini: Colla Corii Asini is sweet, nourishing yin, enriching blood and stopping bleeding. It is a kind of flesh and blood product. Herba et Gemma Agrimoniae is bitter and flat, astringing and stopping bleeding, boosting blood pressure and strengthening heart, regulating heart rate and restoring fatigue. Compatibility of the two drugs, tonifying and astringing, tonifying blood, strengthening heart, astringing and stopping bleeding.
2. With Euphorbia humifusa: Euphorbia humifusa Xin Ping, clearing away heat and toxic materials, promoting blood circulation, cooling blood, stopping bleeding, promoting diuresis and dredging veins. Herba et Gemma Agrimoniae can astringe and replenish qi, strengthen heart and regulate heart rhythm. The combination of the two drugs can cool the blood and dredge the pulse, and adjust the heart rhythm.
3. With Rhizoma Imperatae: Rhizoma Imperatae is sweet and cold, cooling blood to stop bleeding, clearing away heat and diuresis. If it is used with Herba et Gemma Agrimoniae, it will clear away heat, cool blood and stop bleeding. It is often used to treat hematuria.
4. With cuttlebone: cuttlebone tastes salty and astringent, slightly warm, has strong astringency and astringency, and can make acid with the stomach. Agrimonia pilosa is bitter and slightly sweet, and can astringe and stop bleeding and replenish deficiency. It is often used for bleeding due to gastric ulcer and metrorrhagia.
5. With Sophora japonica: Herba et Gemma Agrimoniae converges to stop bleeding, and Sophora japonica cools blood to stop bleeding and clears away damp-heat. The two herbs are often used together, which have the effect of clearing heat, cooling blood and stopping bleeding, and can be used to treat fecal bleeding.
6. Jujube: Take Herba et Gemma Agrimoniae to tonify qi, and jujube tonifies spleen, tonify qi and nourish blood. Matching into tonic formulae can cure the body's nihility. "Zhejiang Tianmu Mountain Medicine Plant Records" is to use Agrimonia pilosa with jujube to treat "children's summer sickness".