Is pituitrin suitable for pulmonary hemoptysis? Pituitrin can be used for pulmonary hemoptysis. The principle of pituitrin in treating hemoptysis is that it can directly act on vascular smooth muscle and has a strong vasoconstrictive effect. Due to the contraction of pulmonary arterioles after medication, the blood flow in the lung decreases sharply and the pulmonary circulation pressure decreases, which is beneficial to the formation of blood clots at the rupture of pulmonary blood vessels and achieves the purpose of hemostasis.
The hemostatic treatment of massive hemoptysis caused by branch expansion is mainly the application of pituitrin. Pituitrin contains two active ingredients, one is oxytocin, and the other is vasopressin, also known as antidiuretic hormone. By directly exciting pulmonary vascular smooth muscle, antidiuretic hormone promotes the contraction of pulmonary arterioles and pulmonary circulation capillaries, thereby reducing pulmonary vascular volume, reducing pulmonary circulation resistance, and making platelets at vascular rupture coagulate to form thrombus to stop bleeding.
The hemostatic effect of pituitrin is positively related to its dosage, but when the dosage increases, it is easy to have gastrointestinal and cardiovascular adverse reactions such as nausea, abdominal pain, abnormal defecation, palpitation, headache and elevated blood pressure, so the medication for patients with hypertension, coronary heart disease and pregnancy is limited. In case of massive hemoptysis, pituitrin 5 ~10u and NS can be diluted to 20 ~ 40ml, and then slowly injected intravenously (10 ~15min), which can be repeated for 2 ~ 6h if necessary. Or10 ~ 20u, add NS250～ 500mL for intravenous drip. Pituitrin can make capillaries and visceral arterioles contract to stop bleeding. When pulmonary tuberculosis hemoptysis occurs, it can be injected. Pituitrin causes pulmonary arterioles to contract, pulmonary vein pressure to decrease, and blood flow to stop bleeding. -Generally, add 5~ 10 units to 10~ 50% glucose solution for 20 ~ 40ml intravenous slow injection, and finish the injection in about 15 minutes. When hemoptysis continues, pituitrin 10~20 units can be added to 500 ml of 5~ 10% glucose solution for intravenous drip.
Which medicine is better for pituitrin? Phentolamine combined with pituitrin can improve the obvious and effective rate and reduce the inefficiency compared with phentolamine alone. Can shorten the time for stopping or relieving hemoptysis; And did not increase the incidence of chest tightness and dizziness. Phentolamine dilates peripheral arteries, and achieves the effect of bleeding from pulmonary circulation to systemic circulation. Pituitrin contracts arterioles to stop bleeding. Combined with phentolamine, on the one hand, it counteracts the pressor effect of pituitrin, on the other hand, it reduces the blood volume of pulmonary circulation, and cooperates with the vasoconstrictive effect of pituitrin to achieve the purpose of stopping bleeding. Hemoptysis is a serious respiratory disease. Pituitrin can directly act on vascular smooth muscle, which has a strong vasoconstrictive effect. After taking the drug, the blood flow in the lung decreases sharply due to the contraction of pulmonary arterioles. Patients should choose appropriate drugs to treat hemoptysis under the guidance of doctors and combined with their own situation.
Nitroglycerin: Combined with pituitrin, the treatment of esophageal variceal bleeding can reduce the side effects and improve the curative effect.
Indomethacin: it can strengthen the effect of desmopressin, and the latter can be reduced appropriately when it is used in the treatment of diabetes insipidus. Chlorpromazine, carbamazepine and tricyclic antidepressants can cause the release of growth hormone (ADH), and the dosage of desmopressin can also be reduced when combined.