The effects of hawthorn leaves are: clearing away heat and toxic materials, lowering blood pressure, relieving itching, healing sores and lowering blood pressure. Main lacquer sore, non-healing ulcer, pharmacological action of hypertension1.Effects on cardiovascular and cerebrovascular systems. One dose or multiple doses of hawthorn leaf polyflavone can antagonize acute myocardial ischemia induced by pituitrin in rabbits and narrow the range of myocardial infarction. Intravenous injection of hawthorn leaf extract (0.1g/ml) at 0.4-8 ml/kg can significantly reduce or restore the S-T segment shift and T wave increase of ECG in guinea pigs caused by pituitrin, and accelerate the heart rate slowdown caused by pituitrin. Vitex rhamnose 20ml/kg can obviously reduce the myocardial oxygen consumption of the dog's sitting heart, which has synergistic effect with hyperoside. The aqueous extract of hawthorn leaves can significantly reduce the serum creatine phosphokinase (CPK) level and myocardial infarction area in rats with coronary artery ligation. When 20% hawthorn extract was injected into the jugular vein for 5-7min, the cerebrovascular resistance decreased1.064-10.91KP/a (8-82 mmhg). 2. Influence on coagulation system. Hawthorn leaves can significantly inhibit rabbit platelet aggregation induced by collagen or ADP in vivo and in vitro. In addition, the specific viscosity of whole blood decreased significantly after intravenous injection of hawthorn leaf preparation for 30min. 3. Hypolipidemic effect Hawthorn leaves have a very significant effect on cholesterolemia in mice rapidly formed by egg yolk emulsion. 4. Anti-hypoxia effect Hawthorn leaves, like propranolol, can significantly prolong the survival time of experimental mice under low pressure or normal pressure hypoxia, which is consistent with the effect of significantly reducing the overall oxygen consumption of mice. 5. Diuretic effect Hawthorn leaf extract has obvious diuretic effect, and the urine volume of rabbits increased by 44.2% after 60min minutes, 53.9% after 90min minutes and 63.7% after120 minutes, indicating that its diuretic effect is mild, slow and lasting, and the effect of Hawthorn leaf on electrolytes is small. 6. Toxicity ① Acute toxicity test: Mice were fed with total flavonoids from hawthorn leaves at the rates of 7.7mg/kg, 3.8 mg/kg and1.9 mg/kg. There was no significant difference in serum alanine aminotransferase (ALT) between the mice and the control group, and no toxic pathological changes were found in heart, liver, spleen, lung, kidney, brain and intestine. ② Three-cause experiment: The total flavonoids of hawthorn leaves were given to pregnant rats by gavage 1 time every day, 200mg/kg and 2000mg/kg, and were examined every 20 days. No adverse effects were found on the fertilized female rats, their pregnancy rate and live fetus rate. Mice were fed with 750mg/kg,1500 mg/kg, and 3000 mg/kg, l times a day for 5 days. The nuclear test of Salmonella/mammals was within the normal range, and there was no significant difference between the rate of abnormal cells (chromosome aberration of bone marrow cells) and the negative control group.