Astragalus efficacy and role
Astragalus efficacy and treatment:
Astragalus health care effects are mainly beneficial to the gas, solid foundation, astringent sweating, muscle, diuresis, elimination of edema and so on.
It is used for the treatment of qi deficiency and weakness, the sinking of the middle qi, prolonged diarrhea and prolapse of the anus, blood in the stool and leakage, surface deficiency and spontaneous sweating, carbuncle and gangrene difficult to ulcerate, long time ulceration does not converge, blood deficiency and atrophy, internal heat and thirst, chronic nephritis, proteinuria, diabetes mellitus, and so on. Scorched Astragalus benefits qi and tonifies the middle, and is used in raw form to stabilize the surface of sores.
Astragalus role:
Enhance non-specific immune function
Astragalus can significantly increase the total number of white blood cells in the blood, promote neutrophils and macrophages phagocytosis and bactericidal ability.
Giving mice some decoction of Astragalus can well increase its spleen NK cell activity, a process that occurs simultaneously with the induction of interferon.
Astragalus polysaccharide can also stimulate the proliferation of NK cells and make the cell body bigger. The promotion of NK cell activity by Astragalus is mainly mediated by induction of 7-interferon production by lymphocytes, and the promotion of NK cell activity by Astragalus parallels its induced antiviral activity.
Astragalus, cultured in vitro with mouse spleen cells, also induced the production of ? -interferon. Both astragalus decoction and astragalus polysaccharide, administered to mice with spleen deficiency caused by rhubarb, restored their spleen's ability to produce IL-2. Astragalus and enhanced the responsiveness of peripheral blood lymphocytes to IL-2, which increased the proliferation index of peripheral blood lymphocytes stimulated by IL-2.
Enhancement of specific immune function
Astragalus can significantly enhance cellular immunity, and promote the transformation of lymphocytes induced by PHA, COnA, and PWM (American meridian). Huangmao on 6OCo one-time whole-body irradiation of mice spleen antibody-producing cells release hemolysin amount, serum lysozyme amount, there is an increase in the effect. On the delayed hypersensitivity reaction and erythrocyte C3b receptor wreath rate, erythrocyte an immune complex wreath formation rate, have different degrees of promotion or enhancement effect.
In addition, although components such as astragalus polysaccharides extracted from Astragalus have significant immune-enhancing effects, components with strong immunosuppressive effects have also been extracted from Astragalus.
Elevating the specific volume of erythrocytes and increasing the number of erythrocytes
Astragalus polysaccharide elevated the specific volume of erythrocytes and increased the number of erythrocytes in normal rats. In rats or mice modeled with blood deficiency syndrome, both Astragalus and Astragalus polysaccharide can elevate the specific volume of erythrocytes or hemoglobin content. Astragalus can also prevent and control the reduction of the total number of peripheral blood leukocytes and bone marrow nucleated cells in mice caused by radiation, and can promote the differentiation and proliferation of hematopoietic stem cells.
Effects on liver
Gavage of Astragalus aqueous decoction in mice can significantly promote the rate of 3H-leucine adulteration of serum and liver proteins in mice, while there is no effect on the protein content, i.e., it can significantly promote the renewal of serum and liver proteins. It can increase the protein synthesis of spleen and proliferate the spleen cells with cytoplasm containing a large amount of rough endoplasmic reticulum. Astragalus has a bidirectional regulatory effect on glucose metabolism, which can significantly reduce the blood glucose level of mice after glucose loading, fight against adrenaline-induced blood glucose elevation, and fight against phenelzine-induced blood glucose reduction in mice. Astragalus has no significant effect on normal blood glucose.
Hepatoprotection Gavage of Astragalus decoction in normal mice can increase liver glycogen. Astragalus on carbon tetrachloride caused by liver damage caused by the serum total protein and albumin decrease has a rebound effect, and can prevent carbon tetrachloride-induced decrease in liver glycogen. Astragalus can increase 3H-leucine adulteration into liver protein to promote its renewal. Chronic hepatitis B patients have cellular immune dysfunction, elevated CD8 and decreased CD4/CD8 ratio in T cell subpopulation, Astragalus injection can make the patient's CD8 decrease and CD4/CD8 increase, restore normal immune function, and improve the ability to clear the virus or inhibit the spread of the virus.
Effects on sperm
Astragalus can prolong the estrous period of mice, and also has a good effect on the development of mice. Astragalus can enhance sperm vitality. Adding Astragalus decoction to human semen in vitro can significantly increase sperm motility, sperm motility speed, sperm forward motility speed, and the frequency of sperm head oscillation. This is potentially valuable for the application of Astragalus as an in vitro additive in assisted reproduction techniques (e.g. artificial insemination, in vitro fertilization, etc.).
Astragalus has the effect of enhancing adrenocortical function and anti-fatigue.
Astragalus can enhance muscle strength in rats and mice. Gavage of Astragalus decoction for 6 days or 14 days in rats can enhance the effect of swimming fatigue resistance in rats, and make the plasma cortisol content of swimming stress rats increased significantly, exceeding the level of blank stress group and normal control group. Astragalus can increase the weight of adrenal gland, thicken the adrenal cortex, and increase the volume and cytoplasmic richness of fascicular zone cells in swimming-stressed rats. It indicated that the enhancement of anti-stress ability of rats by Astragalus was realized through the enhancement of adrenal cortex function.
The effect of slowing down natural aging
Astragalus can extend the average life span of silkworms and Drosophila, and slow down the natural aging process of human fetal lung diploid cells cultured in vitro, so that the cell life span extension of up to 98 generations, the control group only 61-66 generations, so that the life span is extended by l/3. It also has a protective effect on the kidney cell culture in mice. Astragalus and has antioxidant effects, can reduce lipid peroxide and liver lipofuscin content in animal serum. Hydrogen peroxide damage to Chinese hamster lung cells (V79) caused by the reduction of SOD activity, Astragalus total flavonoids have the effect of rebound SOD activity, can reduce the damage of lipid peroxides on the biofilm.
Anti-ulcer
Astragalus extract has inhibitory effect on gastric ulcer in many experimental animals, and has significant inhibitory effect on gastric mucous membrane damage caused by 95% ethanol in mice and gastric mucous membrane damage caused by pylorus ligation in rats, which can reduce the area of damage and lower the damage index, but has no significant effect on gastric juice volume, gastric juice acidity and pepsin activity in rats, and synergizes with the protective effect of cimetidine on gastric mucous membrane. protective effect of cimetidine on the gastric mucosa.
Other
Astragalus also has anti-tumor, anti-osteoporosis and other effects.
Side effects of Astragalus
Three kinds of kidney deficiency
Astragalus
Kidney disease is a deficiency of yin, dampness, heat and toxicity blazing people with Astragalus will generally have toxic side effects, should be prohibited. Because astragalus is sweet, slightly warm, yin deficiency patients take will help heat, easy to hurt yin move blood; and damp heat, heat toxicity blazing patients take easy to stagnate the evil, so that the condition is aggravated. If you have to take astragalus, be sure to use it in combination.
The performance of yin deficiency: there are hot hands and feet, dry mouth and throat, lumbago, hot flashes and night sweats, insomnia, red tongue, no moss, fine pulse. Damp-heat manifestations: bitter mouth, dry mouth, yellow tongue, etc.. The manifestations of heat and toxicity: there are all kinds of purulent infections, such as acne infection, pharyngeal infection, peritonitis, etc., manifested by a full face of redness, pharyngeal redness, pharyngeal dryness, pharyngeal pain, bitter mouth and dry mouth, lips and tongue red and red, tongue with yellow dryness, slippery pulse, etc..
The use of astragalus in patients with yin deficiency must be accompanied by yin-supporting medicines, such as Radix Rehmanniae Praeparata, Radix Rehmanniae Praeparata, Radix et Rhizoma Ginseng, Rhizoma Ophiopogonis, Rhizoma Ophiopogonis, Rhizoma Polygonati, Rhizoma Polygonati Odorati. Damp-heat patients must be accompanied by clearing damp-heat medicines, such as Huanglian, Yin Chen, Scutellaria baicalensis, and so on. Patients with heat and toxicity must be equipped with heat-clearing and detoxifying medicines, such as Huanglian, Gardenia, Rhubarb, Septica, etc.
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