jì shēng shèn qì wán
2 English ReferenceJisheng Shenqi Wan [21st Century Bilingual Dictionary of Science and Technology]
jisheng shenqi pills [Nomenclature Review Committee of Chinese Medicine. Chinese Medicine Nomenclature (2004)]
jisheng shenqi wan [Chinese Medicine Nomenclature Validation Committee. Chinese Medicine Nomenclature (2004)]
3 Overviewjisheng shenqi wan is the name of the formula, i.e., jia wei ren qi wan, which is from Yan's Jisheng Fang, Volume 4 [1].
The main ingredients of the proprietary Chinese medicine Jisheng Kidney Qi Pill are Radix Rehmanniae Praeparata, Cornu Cervi Pantotrichum (made), Mudan Pi, Rhizoma Dioscoreae, Poria, Zelenoides, Cinnamon, Radix Polygoni Multiflori (made), Hyssop, and Psyllium Hirsutum [2]. It has the efficacy of warming kidney and transforming qi, inducing diuresis and eliminating swelling. It is used for kidney deficiency and edema caused by insufficient kidney yang and internal storage of water and dampness, soreness and heaviness of waist and knees, unfavorable urination, phlegm and cough.
The Pharmacopoeia of the People's Republic of China (2010 edition) has recorded the pharmacopoeial standard of Jisheng Kidney Qi Pill.
4 Alias of Jisheng Kidney-Qi PillJiawei Kidney-Qi Pill, Zisheng Kidney-Qi Pill[3][1]
5 IngredientsTwo shelled epiphyllums, two each of Poria cocos, Zedoary, Cornu Cervi Pantotrichum, fried yam, Plantago Ovata Seed (steamed in wine), and Mudan Pi, one each of Guan Gui, Szechuan Cow's Knee (steeped in wine), and half-two of ripened Radix Rehmanniae Praeparata[3].
6 Jisheng Kidney Qi Pill dosageFor fine powder, refined honey for pills, sycamore seed size, each serving seventy pills, fasting rice drink sent down [3].
7 Jisheng Kidney Qi Pill efficacy and treatmentJisheng Kidney Qi Pill has the effect of tonifying the kidney and warming the yang, diuresis and edema [3]. The treatment of kidney deficiency, waist weight, foot swelling, urination is unfavorable; in recent times, it is also used for chronic glomerulonephritis and see the above symptoms [3].
8 Pharmacopoeia standard of Jisheng Shenqi Wan 8.1 NameJisheng Shenqi Wan
Jisheng Shenqi Wan
8.2 Prescription160g of Radix Rehmanniae Praeparata, 80g of Cornu Cervi Pantotrichum, 60g of Mudan Pi, 80g of Rhizoma Coptidis, 120g of Poria, 60g of Alchemilla Officinalis, 20g of Cortex Cinnamomum, 20g of Radix Polygoni Multiflori, 40g of Cortex Pilosulae, Psyllium 40g
8.3 Method of PreparationThe above ten flavors, crushed into fine powder, sieve, mix well. Each 100g of powder with molasses 35 ~ 50g with the appropriate amount of water pan pill, dry, made of molasses pills; or add molasses 90 ~ 110g made of honey pills or honey pills, that is obtained.
8.4 CharacterThis product is brown to dark brown water honey pill, small honey pill or large honey pill; taste sour and slightly sweet, bitter.
8.5 Identification(1) take the product, put under the microscope: paste starch granules clusters of white (appendicitis). Irregularly branched clumps are colorless, dissolved by chloral hydrate; mycelium is colorless or light brown, 4-6μm in diameter (Poria). Thin-walled tissue gray-brown to black-brown, cells more crumpled, containing brown nuclei (Radix Rehmanniae). Thin-walled cells are rounded, with elliptical pores, integrated into groups of pores; endothelial cells perpendicular to the wall of undulating curved, thicker, lignified, with sparse fine pore grooves (Zedoaria). Calcium oxalate sand crystals are present in the thin-walled cells (Hyssop). Calcium oxalate needle bundles are present in the mucous cells, 80-240 μm long, needle crystals 2-5 μm in diameter (yam). The epidermal cells of the pericarp are orange-yellow in color, polygonal in surface view, and the pericyclic wall is thickened in a bead-like manner (Cornus officinalis). The epidermal cells in the testa are oblong-like in surface view, with microwave-like walls, arranged in groups of several cells, slightly mosaic-like (Plantago ovata). The stone cells are rounded or oblong, with a thin wall (cinnamon). Cork cells reddish to purplish, slightly thicker wall (peony bark).
(2) Take 6g of this product water honey pills, crushed, or take small honey pills or large honey pills 9g, cut. Add 50 ml of ether, heating reflux for 2 hours, filtration, filtrate evaporated ether, residue with 1 ml of ether to dissolve, as a test solution. Take the control of salvinorin, add ether to make a solution containing 1mg per 1ml, as the control solution. According to the thin-layer chromatography (2010 version of the Pharmacopoeia, Appendix VI B) test, absorb the above two solutions of 5μl, respectively, point in the same silica gel G thin-layer plate, cyclohexane - ethyl acetate (3:1) as an unfolding agent, unfolding, take out, drying, sprayed with 5% ferric chloride ethanol solution. In the chromatogram of the test article, in the corresponding position with the chromatogram of the control article, show the same color spots.
(3) Take ursolic acid control, add ethanol to make a solution containing 1 mg per 1 ml, as a control solution. According to the thin layer chromatography (2010 version of the Pharmacopoeia, a Appendix VI B) test, absorb 2 μl of the control solution and [identification] (2) under the test solution 5 μl, respectively, point in the same sodium carboxymethylcellulose as a binder silica gel H thin-layer plate, with cyclohexane - trichloromethane - ethyl acetate (20:5:8) as the unfolding agent, unfolding, remove, drying, sprayed with 10% ethanol sulfate solution, and heated at 80 ℃ until the spots showed clear color. In the chromatogram of the test product, in the position corresponding to the chromatogram of the control product, the same color spots; placed in the ultraviolet light (365nm) under the examination, the fluorescent spots of the same color.
(4) take 6g of this product water honey pills, crushed; or take small honey pills or large honey pills 9g, cut into pieces, add 100ml of water, slightly heat so that fully dissolved, heated to boiling, cooled, filtered with cotton wool, the filtrate was extracted with ethyl acetate vibration 2 times, each time 30ml (centrifugation if necessary), combined with ethyl acetate solution, evaporated, residue with 1ml of methanol to make soluble as a solution for the test product. Take 2g of the control herb of Radix Rehmanniae Praeparata, add 50ml of water, decoct for 30 minutes, cool, and make the control herb solution by the same method. According to thin-layer chromatography (2010 version of Pharmacopoeia, Appendix VI B), absorb the above two solutions of 2 ~ 5μl, respectively, point on the same silica gel G thin-layer plate, xylene - ethyl acetate (1:1) as an unfolding agent, unfolding, take out, drying, sprayed with dinitrophenylhydrazine ethanol test solution. In the chromatogram of the test article, in the corresponding position with the chromatogram of the control herb, show the same color spots.
8.6 InspectionShould comply with the relevant provisions under the pill (2010 version of the Pharmacopoeia, a Appendix I A).
8.7 Determination of content 8.7.1 Cornus officinalisDetermined by high performance liquid chromatography (2010 Pharmacopoeia, Appendix VI D).
8.7.1.1 Chromatographic conditions and system suitability testOctadecylsilane-bonded silica gel was used as filler; tetrahydrofuran-methanol-acetonitrile-0.05% phosphoric acid solution (1:3:6:90) was used as the mobile phase; the detection wavelength was 236 nm; and the column temperature was 40 ℃. . Theoretical plate count should be not less than 4000 according to the peak of strychnoside.
8.7.1.2 Preparation of control solutionTake the appropriate amount of strychnoside control, weigh it precisely, add 50% methanol to make a solution containing 20 μg per 1 ml, that is to say, it is obtained.
8.7.1.3 Preparation of test solutionTake the product water honey pills, crushed, take about 1.2g, weighing; or take the small honey pills or weight difference under the large honey pills, cut, mix, take about 1.6g, weighing, put in a stoppered conical flask, add 50% methanol 50ml precision, tightly stoppered, weighed, ultrasonication (power of 250W, frequency of 33kHz) 15 minutes to make dissolution, heating reflux 1 hour, cooled, then weighing, with 50% methanol to make up for the loss of weight, shaking well, filtered. Precision measure 10ml of filtrate, add in neutral alumina column (100-200 mesh, 4g, inner diameter of 1cm), eluted with 40% methanol 50ml, collect effluent and eluent, evaporate, the residue with 50% methanol dissolved, transferred to a 5ml measuring flask, add 50% methanol to the scale, shaking, filtration, and filtration, take the filtrate, that is, obtained.
8.7.1.4 DeterminationPrecisely aspirate 10μl each of the control solution and test solution, inject into the liquid chromatograph, determination, that is, obtained.
This product contains Cornus officinalis (C17H26O10), not less than 0.38mg per 1g of water honey pill; not less than 0.27mg per 1g of small honey pill; not less than 2.4mg per pill of large honey pill.
8.7.2 MudanpiDetermined by high performance liquid chromatography (2010 version of the Pharmacopoeia, Appendix VI D).
8.7.2.1 Chromatographic conditions and system suitability testOctadecylsilane-bonded silica gel was used as filler; methanol-water (50:50) was used as the mobile phase; the detection wavelength was 274 nm, and the theoretical plate number should be not less than 4000 according to the peak of danpi phenol.
8.7.2.2 Preparation of the controlThe control of danpi phenol was taken. Appropriate amount of the product, precision weighing, add methanol to make a solution containing 20 μg per 1 ml, that is obtained.
8.7.2.3 Preparation of test solutionTake the product water honey pills, crushed, take about 0.4g, weighing; or take small honey pills or weight difference under the large honey pills, cut, mix, take about 0.5g, weighing, set in a stoppered conical flask, add 50% methanol 50 ml precision, tightly stoppered, weighed, ultrasonication (power of 250W, frequency of 33kHz) 45 minutes, cool, weigh again, with 50% methanol to make up for the loss of weight, shake well, filter, take the filtrate, that is obtained.
8.7.2.4 DeterminationPrecisely draw 10μl of the control solution and 20μl of the test solution, inject into the liquid chromatograph, and then determine, it is obtained.
This product contains peony dangdanpi in terms of danpi phenol (C9H10O3), water honey pills shall not be less than 0.58mg per 1g; small honey pills shall not be less than 0.42mg per 1g; large honey pills shall not be less than 3.8mg per pill.
8.8 Functions and IndicationsWarming the kidneys and transforming the qi, inducing diuresis to reduce water retention and swellings. It is used in treating kidney deficiency and edema, soreness and heaviness of waist and knees, dysuria, phlegm and cough due to insufficiency of kidney yang and internal retention of water-dampness.
8.9 Dosage and AdministrationOral. 6g of water honey pills, 9g of small honey pills, 1 pill of large honey pills, 2-3 times a day.
8.10 SpecificationsLarge honey pills weighing 9g per pill
8.11 StorageSealed.
8.12 VersionChinese People's Pharmacopoeia 2010 Edition
9 Jisheng Kidney Qi Pills Drug Description 9.1 Drug NameJisheng Kidney Qi Pills
9.2 Drug Hanyu PinyinJisheng Shenqi Wan
9.3 Dosage FormLarge honey pill, each pill weighs 9g.
9.4 PropertiesJisheng Kidney Qi Pills are brown to black to black in color. Jisheng Shenqi Wan is brown to dark brown water honey pill, small honey pill or big honey pill; taste sour and slightly sweet, bitter.
9.5 The main ingredients of Jisheng Kidney Qi PillsCooked Di Huang, Cornus officinalis (made), Mudan Pi, Chinese yam, Poria, Zeligia, Cinnamon, Radix et Rhizoma Polygonati Odorati, Radix et Rhizoma Polygonati Odorati, Radix et Rhizoma Polygonati Odorati, Radix et Rhizoma Pilosulae.
9.6 Pharmacological effects of Jisheng Kidney Qi PillCooked Di Huang nourishes kidney yin and benefits essence; Cornu Cervi Pantotrichum and Chinese yam nourish the liver and spleen and enhance the effect of tonifying kidney yin; and a small amount of Cinnamon and Radix et Rhizoma Polygonati Odorati warms up the kidney to help the yang, transforms the qi to move the water, which is complementary with the medicine for nourishing kidney yin and nourishes the fire in the water and warms up the yang of the kidney; Zedoaria, Poria, Plantago ovata seeps out the dampness and promotes water retention to reduce swelling; Dampi clears the liver; Cowslip induces the drug to: downward movement and tends to lower Jiao to strengthen the lumbar knees. Strong waist and knees. The combination of drugs, *** play warm kidney gas, diuresis and swelling.
9.7 Functions of Jisheng Kidney Qi PillWarming the kidneys and transforming qi, diuresis and swelling. It is used for kidney deficiency and edema caused by insufficient kidney yang and internal storage of water and dampness, soreness and heaviness of waist and knees, unfavorable urination, phlegm and coughing. It is suitable for edema of yin water; dropsy; retention of urine.
9.8 Usage and dosage of Jisheng Kidney Qi PillsOral. Water honey pill once 6g, small honey pill once 9g, large honey pill once 1 pill, 2-3 times a day.
9.9 Precautions1. Jisheng Kidney Qi Pill is warm, dry and osmotic product, pregnant women should be cautious.
2. Avoid cold, greasy, spicy *** products during the period of taking the medicine, in order to prevent the formation of dampness and phlegm.
9.10 Expert Comment