SAA's full name is serum amyloid A, which is an acute phase protein secreted into the serum after being produced by liver cells. When the body is infected or injured, it can rapidly increase by about 1000 times within 4-6 hours, and then rapidly decrease to the normal level after the body antigen is cleared.

Characteristics of SAA:

1, rapid increase and rapid decrease: SAA is an acute phase protein, which can quickly increase by about 1000 times within 4-6 hours after infection, and can quickly decrease to normal level after pathogen removal, which is a sensitive index to reflect the infection and inflammation recovery of the body;

2. Complementary application: Compared with CRP, which is widely used in clinic at present, SAA has one most important difference: SAA is increased in viral, mycoplasma and bacterial infections, and its sensitivity is higher than CRP; The increase of CRP is seen in bacterial infection, and the infection of pathogens such as virus and mycoplasma does not increase or only slightly increases.

Extended data:

Clinical significance of SAA

1 and SAA are sensitive indicators for the diagnosis of virus and bacterial infection. Compared with CRP, SAA has the advantages of early rise, large amplitude and high sensitivity, especially in the early stage of acute bacterial infection.

2. SAA in viral infectious diseases, SAA is significantly increased, but CRP is not increased, so SAA can be used as a sensitive index to diagnose viral infection;

3. SAA combined with CRP detection can differentiate and diagnose bacterial and viral infections, provide a new basis, be more reliable, dynamically observe the curative effect and guide clinical medication;

4. SAA combined with CRP and PCT is beneficial to the early diagnosis of infectious diseases in children (neonatal septicemia and sepsis).

Yibin No.2 People's Hospital-Serum Amyloid A(SAA)