Contents 1 Pinyin 2 Overview 3 Alias ??of Liuwei Dihuang Pills plus Zhimu Huangbaifang 4 Composition 5 Usage and dosage of Liuwei Dihuang Pills plus Zhimu Huangbaifang 6 Efficacy and indications of Liuwei Dihuang Pills plus Zhimu Huangbaifang 7 Source 8 Pharmacopoeia standards of Zhibai Dihuang Pills 8.1 Product name 8.2 Prescription 8.3 Preparation method 8.4 Properties 8.5 Identification 8.6 Inspection 8.7 Content determination 8.7.1 Dogwood 8.7.1.1 Chromatographic conditions and system suitability test 8.7.1.2 Preparation of reference solution 8.7. 1.3 Preparation of test solution 8.7.1.4 Determination method 8.7.2 Moutan bark 8.7.2.1 Chromatographic conditions and system suitability test 8.7.2.2 Preparation of reference solution 8.7.2.3 Preparation of test solution 8.7.2.4 Determination method 8.8 Functions and indications 8.9 Usage and dosage 8.10 Specifications 8.11 Storage 8.12 Version 9 Pharmacopoeia standards for Zhibai Dihuang Pills (concentrated pills) 9.1 Product name 9.2 Prescription 9.3 Preparation method 9.4 Properties 9.5 Identification 9.6 Inspection 9.7 Content determination 9.7.1 Dogwood 9.7.1.1 Chromatographic conditions and system suitability test 9.7.1.2 Preparation of reference solution 9.7.1.3 Preparation of test solution 9.7.1.4 Determination method 9.7.2 Mudan bark 9.7.2.1 Chromatographic conditions and system suitability test 9.7.2.2 Preparation of reference solution 9.7.2.3 Preparation of test solution 9.8 Functions and indications 9.9 Usage and dosage 9.10 Specifications 9.11 Storage 9.12 Version 10 Standards issued by the Ministry of Traditional Chinese Medicine for Zhibai Dihuang Pills 10.1 Dosage form 10.2 Pinyin name 10.3 Standard number 10.4 Prescription 10.5 Preparation method 10.6 Properties 10.7 Identification 10.8 Inspection 10.9 Functions and indications 10.10 Usage and dosage 10.11 Specifications 10.12 Storage 11 Zhibai Dihuang Pills drug instructions 11.1 Drug name 11.2 Drug Chinese Pinyin 11.3 Dosage form 11.4 Properties 11.5 Main ingredients of Zhibai Dihuang Pills 11.6 Pharmacological effects of Zhibai Dihuang Pills 11.7 Zhibai Dihuang Pills Functions and indications of Bai Dihuang Pills 11.8 Usage and dosage of Zhibai Dihuang Pills 11.9 Precautions 11.10 Interactions between Liuwei Dihuang Pills plus Zhimu Huangbaifang and other drugs 11.11 Expert comments 11.12 Remarks 12 References attached: 1 Liuwei Dihuang Pills plus Anemarrhena Huangbaifang in ancient books Anemarrhena Huangbaifang 1 Pinyin

liù wèi dì huáng wán jiā zhī mǔ huáng bǎi fāng 2 Overview

Liuwei Dihuang Pill plus Anemarrhena Huangbaifang is the name of the prescription, which is the name of the prescription, that is, "Text of Medical Prescriptions" "Volume 3: Ziyin Bawei Pills[1][2]. It is also known as Zhibai Bawei Pill and Zhibai Dihuang Pill (Volume 1 of "Syndrome Causes and Pulses Treatment") [1].

The main ingredients of the Chinese patent medicine Zhibai Dihuang Pills are Anemarrhena, Phellodendron, Rehmannia glutinosa, Cornus officinale (made from), Mudan bark, Poria, Alisma, and Chinese yam [3]. It has the effect of nourishing yin and reducing fire. It is used for yin deficiency and excessive fire, hot flashes and night sweats, dry mouth and sore throat, tinnitus and spermatorrhea, and short and red urine.

The "Drug Standards of the People's Republic of China and the Ministry of Health" contains the ministry-issued standards for Zhibai Dihuang Pills.

"The Pharmacopoeia of the People's Republic of China" (2010 edition) records the pharmacopoeia standards of Zhibai Dihuang Pills and Zhibai Dihuang Pills (concentrated pills).

3 Alias ??of Liuwei Dihuang Pills plus Anemarrhena Huangbaifang

Liuwei Dihuang Pills plus Anemarrhena Huangbaifang (original name)

Zhibai Bawei Pills

Composition of 4 Ziyin Bawei Pills

Four liang each of Chinese yam and dogwood, three liang each of peony bark, poria, Alisma, cork bark (stir-fried in salt water), and anemarrhena (stir-fried in salt water), Eight liang of Rehmannia glutinosa [1].

5 Usage and Dosage of Liuwei Dihuang Pills plus Anemarrhena Huangbaifang

Make it into fine powder, refine the honey into pills, and make them into big sycamore seeds. Take 100 pills each time, take it with boiled water or light salt soup on an empty stomach or before noon [1] . 6 The efficacy and indications of Liuwei Dihuang Pills plus Anemarrhena Huangbaifang

Zhibai Dihuang Pills have the effect of nourishing yin and reducing fire. It can be used to treat kidney strain, difficulty in tilting the back, difficulty in urination with residual drainage, sores due to dampness in the cyst, urgency in the lower abdomen, yellow and red stools, and bone steaming and hot flashes due to yin deficiency and excess fire [1]. 7 Sources

Volume 1 of "Treatment of Symptoms, Causes and Pulses"

Volume 3 of "Treatment of Medical Prescriptions" 8 Pharmacopoeia Standards of Zhibai Dihuang Pills 8.1 Product Name

Zhibai Rehmannia Pills

Zhibai Dihuang Wan 8.2 Prescription

Anemarrhena 40g, Phellodendron 40g, Rehmannia glutinosa 160g, Dogwood (made) 80g, Mudan bark 60g, Chinese yam 80g, Poria 60g, Alisma 60g 8.3 Preparation method

Crush the above eight flavors into fine powder, sieve and mix well. For every 100g of powder, add an appropriate amount of watered honey pills to 35-50g of refined honey, and dry to make water-based honey pills; or add 80-110g of refined honey to make small honey pills or large honey pills. 8.4 Properties

This product is brown-black water honey pills, dark brown small honey pills or large honey pills; it tastes sweet but sour and bitter. 8.5 Identification

(1) Take this product and observe it under a microscope: the starch granules are triangular, oval or oblong, with a diameter of 24-40 μm, and the umbilical point is short slit-shaped or herringbone-shaped (yam). The irregular branched clumps are colorless and dissolve when exposed to chloral hydrate test solution; the hyphae are colorless or light brown, with a diameter of 4 to 6 μm (Poria cocos). The parenchyma is gray-brown to dark brown, with many wrinkled cells containing brown nuclei (rehmannia glutinosa). Calcium oxalate needle crystals are in bundles or scattered, 26 to 110 μm long (Anemarrhena). Calcium oxalate clusters exist in colorless parenchyma cells, sometimes several arranged in rows (moutan bark). The epidermal cells of the peel are orange-yellow, polygonal in appearance, and the vertical wall is bead-like thickened (Corus officinalis). The parenchyma cells are round in shape, with oval pits and integrated pit groups; the vertical walls of the endothelial cells are wavy, thick, lignified, and have sparse pores and grooves (Alismatis). The fiber bundles are bright yellow, and the surrounding cells contain calcium oxalate square crystals, forming crystal fibers. The walls of the crystal-containing cells are woody and thickened (cork).

(2) Take 6g of this product’s water honey pills and grind them into pieces; or take 9g of small honey pills or big honey pills and cut them into pieces. Add 15 ml of ether, shake for 15 minutes, leave for 1 hour, filter, evaporate the ether from the filtrate, add 1 ml of acetone to the residue to dissolve, and use it as the test solution. Take another paeonol reference substance, add acetone to make a solution containing 1mg per 1ml, and use it as the reference substance solution. According to the thin layer chromatography (Appendix VI B of Pharmacopoeia 2010 Edition) test, draw 10 μl of each of the above two solutions, respectively point on the same silica gel G thin layer plate to form a strip, and use cyclohexane-ethyl acetate (3 : 1) As a developing agent, unfold, take out, dry, spray with acidic 5% ferric chloride ethanol solution of hydrochloric acid, and heat until the spots appear clear. In the chromatogram of the test product, the same blue-brown stripes appear at the corresponding position of the chromatogram of the reference substance.

(3) Take 2g of this product, chop it into pieces, add 5ml of methanol, heat and reflux for 15 minutes, filter, take the filtrate, add methanol to make 5ml, as the test solution. Take another 0.1g of the yellow phase reference medicinal material and prepare the reference medicinal material solution in the same way. Then take the Berberis hydrochloride reference substance, add methanol to make a solution containing 0.5mg per 1ml, and use it as the reference substance solution. According to the thin layer chromatography (Appendix VI B of Pharmacopoeia 2010 Edition) test, draw 1 μl of each of the above three solutions, respectively point on the same silica gel G thin layer plate, and use benzene-isopropyl alcohol-ethyl acetate-methanol-concentrated Ammonia test solution (12:3:6:3:1) is used as the developing agent. Place it in a development cylinder presaturated with ammonia vapor, unfold it, take it out, dry it, and inspect it under a UV lamp (365nm). In the chromatogram of the test product, the same yellow fluorescent spot appears at the position corresponding to the chromatogram of the control medicinal material and the reference substance chromatogram. 8.6 Inspection

It should comply with the relevant regulations under pills (Appendix I A of the 2010 edition of the Pharmacopoeia). 8.7 Content determination 8.7.1 Cornus officinale

Determination according to high performance liquid chromatography (2010 edition of Pharmacopoeia, Appendix VI D). 8.7.1.1 Chromatographic conditions and system suitability test

Use octadecylsilane bonded silica gel as filler; use tetrahydrofuran-methanol-acetonitrile-0.05% phosphoric acid solution (1:4:8:87) is the mobile phase; the column temperature is 40°C; the detection wavelength is 236nm. The number of theoretical plates should not be less than 4000 based on the loganin peak. 8.7.1.2 Preparation of reference substance solution

Take an appropriate amount of loganin reference substance, weigh it accurately, and add 50% methanol to prepare a solution containing 40 μg per 1 ml. 8.7.1.3 Preparation of the test solution

Take the water honey pills of this product, grind it, take 0.7g, and weigh it accurately; or take the small honey pills or the large honey pills under the weight difference item, and cut them into pieces , mix well, take about 1g and weigh it accurately.

Place the stoppered Erlenmeyer flask, add 25ml of 50% methanol accurately, seal the stopper, weigh it, ultrasonic treatment (power 250W, frequency 33kHz) for 15 minutes, heat and reflux for 1 hour, let cool, weigh again, use 50% Use methanol to make up for the lost weight, shake well, filter, accurately measure 10 ml of the additional filtrate, add it to a neutral alumina column (100 to 200 mesh, 4 g, inner diameter 1 cm), elute with 50 ml of 40% methanol, and collect Evaporate the effluent and eluate to dryness, dissolve the residue with 50% methanol, transfer to a 5ml measuring flask, add 50% methanol to the mark, shake well, filter, and take the filtrate to obtain. 8.7.1.4 Determination method

Precisely draw 10 μl each of the reference solution and the test solution, inject them into the liquid chromatograph, and measure.

This product contains Cornus officinale. Calculated as loganin (C17H26O10), each 1g of Shuimi Pills shall not be less than 0.53 mg; each 1g of Xiaomi Pills shall not be less than 0.40 mg; each pill of Dami Pills shall not be less than 3.6 mg. 8.7.2 Moutan bark

Determination according to high performance liquid chromatography (Appendix VI D of Pharmacopoeia 1, 2010 edition). 8.7.2.1 Chromatographic conditions and system suitability test

Use octadecylsilane bonded silica gel as the filler; use methanol-water (70:30) as the mobile phase; the detection wavelength is 274nm. The number of theoretical plates should not be less than 3500 based on the paeonol peak. 8.7.2.2 Preparation of reference substance solution

Take an appropriate amount of paeonol reference substance, weigh it accurately, and add methanol to make a solution containing 15 μg per 1 ml. 8.7.2.3 Preparation of the test solution

Take the water honey pills of this product, grind it, take 0.4g, and weigh it accurately; or take the small honey pills or the large honey pills under the weight difference item, and cut them into pieces , mix evenly, take 0.5g and weigh it accurately. Place it in a stoppered Erlenmeyer flask, add 50 ml of 50% methanol accurately, seal the stopper, weigh it, ultrasonicate (power 250W, frequency 33kHz) for 45 minutes, let it cool, weigh it again, and use 50% methanol to make up for the loss. weight, shake well, filter, and take the remaining filtrate to get it. 8.7.2.4 Determination method

Precisely pipette 10 μl of the reference solution and 20 μl of the test solution, inject them into the liquid chromatograph, and measure.

This product contains peony bark. Calculated as paeonol (C9H10O3), each 1g of Shuimi Pills should not be less than 0.80mg; each 1g of Xiaomi Pills should not be less than 0.55mg; each pill of Dami Pills should not be less than 0.80mg. 5.0mg. 8.8 Functions and indications

Nourishes yin and reduces fire. It is used for yin deficiency and excessive fire, hot flashes and night sweats, dry mouth and sore throat, tinnitus and spermatorrhea, and short and red urine. 8.9 Usage and dosage

Take orally. Water honey pills are 6g at a time, small honey pills are 9g at a time, and big honey pills are 1 pill at a time, twice a day. 8.10 Specifications

Dami pills? Each pill weighs 9g 8.11 Storage

Sealed. 8.12 version

"Pharmacopoeia of the People's Republic of China" 2010 Edition 9 Pharmacopoeia Standards for Zhibai Dihuang Pills (Concentrated Pills) 9.1 Product Name

Zhibai Dihuang Pills (Concentrated Pills)

Zhibai Dihuang Wan 9.2 Prescription

Anemarrhena 25.9g, Phellodendron 25.9g, Rehmannia glutinosa 103.4g, Dogwood (made) 51.7g, Mudan Bark 38.8g, Chinese yam 51.7g, Poria 38.8g, Alisma 38.8g 9.3 Preparation method

For the above eight ingredients, crush yam, 13g of peony bark, and 21g of dogwood into fine powder and set aside; crush Alisma, Poria, Anemarrhena, and Phellodendron into coarse powder , add water and decoct twice, the first time for 3 hours, the second time for 2 hours, combine the decoctions, filter, and concentrate the filtrate into a clear paste with a relative density of 1.35 to 1.40 (20°C); take the cooked rehmannia glutinosa and decoct it with water for three times. , the first time is 3 hours, the second time is 2 hours, and the third time is 1 hour, combine the decoctions, filter, and concentrate the filtrate into a clear paste with a relative density of 1.35 to 1.40 (20°C); take the remaining peony bark and dogwood , use 70% ethanol as the solvent, soak for 24 hours, then percolate, collect the percolate, recover the ethanol, and concentrate it into a clear paste with a relative density of 1.35 to 1.40 (20°C); mix the above clear paste, medicinal powder and an appropriate amount Mix the starch to make 1000 pills, dry and polish, and you have it. 9.4 Properties

This product is a dark brown concentrated pill with slight odor, bitter and sour taste. 9.5 Identification

(1) Take this product and observe it under a microscope: calcium oxalate clusters exist in colorless parenchyma cells, sometimes several arranged in a row (moutan bark). Starch granules are triangular, oval or oblong, with a diameter of 24-40 μm, and a short slit or herringbone (yam) shape at the umbilicus. The epidermal cells of the fruit peel are orange-yellow, polygonal in appearance, and the vertical wall is thickened in a bead-like manner (Corus officinalis).

(2) Take 6g of this product, grind it finely, add 15ml of ether, shake for 15 minutes, leave it for 1 hour, filter, evaporate the ether from the filtrate, add 1ml of acetone to the residue to dissolve, and use it as a test sample solution. Take another paeonol reference substance, add acetone to make a solution containing 1mg per 1ml, and use it as the reference substance solution. According to the thin layer chromatography test (Appendix VI B of Pharmacopoeia 2010 edition), draw 5 to 10 μl of each of the above two solutions, and spot them on the same silica gel G thin layer plate. Use cyclohexane-ethyl acetate (3:1 ) as the developing agent, unfold, take out, dry, spray with acidic 5% ferric chloride ethanol solution of hydrochloric acid, and heat until the spots appear clear. In the chromatogram of the test product, the same blue-brown spots appear at the corresponding positions of the chromatogram of the reference substance.

(3) Take 2g of this product, grind it finely, add 5ml of methanol, heat and reflux for 15 minutes, filter, add methanol to the filtrate to 5ml, and use it as the test solution. Take another 0.1g of Phellodendron cork control medicinal material and prepare the reference medicinal material solution in the same way. Then take the Berberis hydrochloride reference substance, add methanol to make a solution containing 0.5mg per 1ml, and use it as the reference substance solution. According to the thin layer chromatography test (Appendix VI B of the 2010 edition of the Pharmacopoeia), draw 1 μl of each of the above three solutions, place them on the same silica gel G thin layer plate, and use xylene-isopropyl alcohol-ethyl acetate-methanol- Use water (12:3:6:3:1) as the developing agent, place it in a development cylinder saturated with ammonia vapor, unfold it, take it out, dry it, and inspect it under an ultraviolet light (365nm). In the chromatogram of the test product, the same yellow fluorescent spot appears at the position corresponding to the chromatogram of the control medicinal material and the reference substance chromatogram.

(4) Take 10g of this product, grind it finely, add 100ml of water, warm it to fully dissolve, heat to boiling, let cool, filter, take the filtrate, extract it twice with ethyl acetate, each time 30ml, combine the ethyl acetate solution, evaporate to dryness, add 1ml of methanol to the residue to dissolve, and use it as the test solution. Take another 4g of Rehmannia glutinosa control medicinal material, add 60ml of water, boil for 30 minutes, let cool, filter, extract the filtrate twice with ethyl acetate, 20ml each time, combine the ethyl acetate liquid, evaporate to dryness, add 1ml of methanol to the residue to dissolve , as a control medicinal solution. According to the thin layer chromatography test (Appendix VI B of Pharmacopoeia 2010 Edition), draw 3 to 5 μl of each of the above two solutions, and spot them on the same silica gel G thin layer plate. Use xylene-ethyl acetate (1:1) As a developing agent, unfold, take out, dry, and spray with 2,4 dinitrophenylhydrazine ethanol test solution. In the chromatogram of the test product, spots of the same color appear at the positions corresponding to the chromatogram of the control medicinal material. 9.6 Inspection

It should comply with the relevant regulations under pills (Appendix I A of the 2010 edition of the Pharmacopoeia). 9.7 Content determination 9.7.1 Cornus officinale

Determination according to high performance liquid chromatography (2010 edition of Pharmacopoeia, Appendix VI D). 9.7.1.1 Chromatographic conditions and system suitability test

Use octadecylsilane bonded silica gel as filler; use tetrahydrofuran-methanol-acetonitrile-0.05% phosphoric acid solution (1:4:8:87) is the mobile phase; the column temperature is 40°C; the detection wavelength is 236nm. The number of theoretical plates should not be less than 4000 based on the loganin peak. 9.7.1.2 Preparation of reference substance solution

Take an appropriate amount of loganin reference substance, weigh it accurately, and add 50% methanol to prepare a solution containing 20 μg per 1 ml. 9.7.1.3 Preparation of test solution

Take an appropriate amount of this product, grind it finely, take about 0.4g, weigh it accurately, place it in a stoppered conical flask, add 50ml of 50% methanol accurately, and seal it tightly. , weigh it, heat and reflux for 1 hour, let it cool, weigh it again, make up for the lost weight with 50% methanol, shake well, and filter. Precisely measure 10 ml of the continued filtrate, add it to a neutral alumina column (100 to 200 mesh, 4 g, inner diameter 1 cm), elute with 50 ml of 40% methanol, collect the effluent and eluate, evaporate to dryness, and add 50 to the residue. % methanol to dissolve, transfer to a 10ml measuring flask, dilute to the mark with 50% methanol, shake well, and it is ready. 9.7.1.4 Determination method

Precisely draw 10 μl each of the reference solution and the test solution, inject them into the liquid chromatograph, and measure.

Each 1g of this product contains Cornus officinale, calculated as loganin (C17H26O10), which shall not be less than 1.0mg. 9.7.2 Moutan bark

Determine according to high performance liquid chromatography (2010 edition of Pharmacopoeia, Appendix VI D). 9.7.2.1 Chromatographic conditions and system suitability test

Use octadecylsilane bonded silica gel as the filler; use methanol-water (70:30) as the mobile phase; the detection wavelength is 274nm. The number of theoretical plates should not be less than 3500 based on the paeonol peak. 9.7.2.2 Preparation of reference substance solution

Take an appropriate amount of paeonol reference substance, weigh it accurately, and add methanol to make a solution containing 20 μg per 1 ml.

9.7.2.3 Preparation of test solution

Take an appropriate amount of this product, grind it finely, take about 0.4g, weigh it accurately, place it in a stoppered conical flask, add 50ml of 50% methanol accurately, and seal it tightly. , weigh it, conduct ultrasonic treatment (power 250W, frequency 33kHz) for 30 minutes, let it cool, weigh it again, use 50% methanol to make up for the lost weight, shake well, filter, and take the filtrate to get it. Determination method: Precisely draw 10 μl each of the reference solution and the test solution, inject them into the liquid chromatograph, and measure.

Every 1g of this product contains paeonol (C9H10O3) from peony bark, which should not be less than 1.5mg. 9.8 Functions and indications

Nourishes yin and reduces fire. It is used for yin deficiency and excessive fire, hot flashes and night sweats, dry mouth and sore throat, tinnitus and spermatorrhea, and short and red urine. 9.9 Usage and dosage

Oral administration. Take 8 pills at a time, 3 times a day. 9.10 Specifications

Each 10 pills weigh 1.7g 9.11 Storage

Sealed. Version 9.12

"Pharmacopoeia of the People's Republic of China" 2010 Edition 10 Ministry of Traditional Chinese Medicine Standard for Zhibai Dihuang Pills 10.1 Dosage Form

Concentrated Pills 10.2 Pinyin Name

WS3B135793 10.4 Prescription

Anemarrhena 40g

Rehmannia glutinosa 160g

Phellodendron 40g < /p>

Dogwood? 80g

Chinese yam 80g

Mudan bark? 60g

Poria 60g

Alisma 60g 10.5 made Method

For the above eight flavors, grind Alisma, Poria, Anemarrhena, and Phellodendron into coarse powder, add water and boil for two times, the first time for 3 hours, the second time for 2 hours, combine the decoctions, and filter. After passing through, the filtrate is concentrated into a clear paste with a relative density of 1.30 ~ 1.35 (20 ℃); take slices of cooked rehmannia glutinosa, add water and decoct three times, the first time for 3 hours, the second time for 2 hours, the third time for 1 hour, and combine the decoctions , filter, and the filtrate is concentrated into a clear paste with a relative density of 1.30 to 1.35 (20°C); take 40g of peony bark and 46.9g of dogwood, and follow the percolation method under the extract and extract (Appendix page 17) , use &0% ethanol as the solvent, soak for 24 hours, then percolate, collect the percolation liquid, recover the ethanol, and concentrate it into a clear paste with a relative density of 1.30 to 1.35 (20°C); take the yam, the remaining dogwood and the remaining peony bark. Crush it into fine powder, mix it with the above-mentioned clear pastes to make pills, dry and polish, and you can get it. 10.6 Properties

This product is a dark brown concentrated pill with slight odor, bitter and sour taste. 10.7 Identification

Take this product and observe it under a microscope: calcium oxalate clusters exist in colorless parenchyma cells, sometimes several of them arranged in a row. Calcium oxalate needle crystal bundles exist in mucus cells and are 80 to 240 μm long. The diameter of needle crystals is 2-8 μm. The epidermal cells of the peel are orange-yellow, with a polygonal surface and slightly bead-like thickening of the vertical wall. 10.8 Inspection

It should comply with the relevant regulations under pills (Appendix page 8) 10.9 Functions and indications

Nourishing yin and reducing fire. Used for yin deficiency and excessive fire, hot flashes, night sweats, sore throat, tinnitus, spermatorrhea, short red urine 10.10 Usage and dosage

Take orally, 8 pills at a time, 3 times a day. 10.11 Specifications

Each 8 pills is equivalent to 3g of native medicine 10.12 Storage

Sealed? 11 Zhibai Dihuang Wan Drug Instructions 11.1 Drug Name

Zhibai Dihuang Wan 11.2 Drug Chinese Pinyin

Zhibai Dihuang Wan 11.3 Dosage Form

Damee Pills, each pill Weighs 9g; concentrated pills weigh 1.7g per 10 pills. 11.4 Characteristics

Zhibai Dihuang Pills are brown-black water honey pills, dark brown small honey pills or large honey pills; they taste sweet but sour and bitter. 11.5 The main ingredients of Zhibai Dihuang Pills

Anemarrhena, Cortex Phellodendri, Rehmannia glutinosa, Cornus officinalis (manufactured), moutan bark, yam, Poria, Alisma 11.6 Pharmacological effects of Zhibai Dihuang Pills

Mice taking Zhibai Dihuang Pills 2.5g/kg and 5.0g/kg can reduce the blood sugar of normal mice and alloxan-induced diabetic mice, and can also reduce the daily water intake of mice.

2. Clinical reports: ① Sexual dysfunction: Zhibai Dihuang Pills were used to treat 47 cases of spermatorrhea aged 18 to 38 years old. They were divided into yin-excessive-fire-exuberant type, damp-heat-deficient type and kidney-deficient ingestion type. One dose per day. , 36 cases (76.5%) were cured, 7 cases (15%) were improved, and 4 cases (8.5%) were ineffective after taking it twice. ② Single benign thyroid nodule: 26 cases of this disease were treated with Zhibai Dihuang Pills alone, 9g each time, or its concentrated pills 8 pills each time, 3 times a day, 90 days as a course of treatment. After 1 to 2 courses of treatment, 20 cases, accounting for 77%, were confirmed to have disappeared by examination and B-ultrasound; 4 cases, accounting for 15%, had shrinkage compared with before treatment, and 2 cases had no change compared with before treatment, and there were always The efficiency is 92%, and most patients will have curative effects after one course of treatment. ③Deafness: Zhibai Dihuang Pills were used to treat 44 cases of deafness symptoms caused by aminoglycosides, 2 pills/time, once a day in the morning and evening, with warm water. 32 cases were cured in 2 to 5 days (16 cases of simple tinnitus) For example, 16 cases had tinnitus accompanied by vertigo), 10 cases improved after taking the medicine for 5 to 10 days (8 cases had tinnitus with vertigo, 2 cases had tinnitus with hearing loss), 2 cases had no effect after taking the medicine for more than 15 days, and the total effective rate was 95.5% . Human body surface area calculator BMI index calculation and evaluation Female safe period calculator Pregnancy date calculator Normal weight gain during pregnancy Safety classification of medication during pregnancy (FDA) Five elements and eight characters Adult blood pressure evaluation Body temperature level evaluation Diabetes diet recommendations Common clinical biochemistry units Conversion to basal metabolic rate Calculate sodium supplementation calculator Iron supplementation calculator Commonly used Latin abbreviations for prescription Quick check Common symbols for pharmacokinetics Quick check Effective plasma osmolarity calculator Ethanol intake calculator

Medical encyclopedia, calculate now! 11.7 The main functions of Zhibai Dihuang Pills

Nourishing yin and reducing fire. It is used for yin deficiency and excessive fire, hot flashes and night sweats, dry mouth and sore throat, tinnitus and spermatorrhea, and short and red urine. 11.8 Usage and dosage of Zhibai Dihuang Pills

Take orally. Water honey pills are 6g at a time, small honey pills are 9g at a time, and big honey pills are 1 pill at a time, twice a day. Concentrated pills: 8 pills at a time, 3 times a day. 11.9 Precautions

1. Avoid foods that are difficult to digest.

2. Patients with colds and fever should not take it.

3. People with serious chronic diseases such as high blood pressure, heart disease, liver disease, diabetes, and kidney disease should take it under the guidance of a physician.

4. Children, pregnant women, and lactating women should take it under the guidance of a physician.

5. If the symptoms are not relieved after taking the medicine for 4 weeks, you should go to the hospital for treatment.

6. It is forbidden for those who are allergic to Zhibai Dihuang Pills, and it should be used with caution by those with allergies.

7. It is forbidden to use Zhibai Dihuang Pills when its properties change.

8. Children must use it under adult supervision.

9. Please keep Zhibai Dihuang Pills out of reach of children.

10. If you are using other drugs, please consult your physician or pharmacist before using Zhibai Dihuang Pills. 11.10 Drug interactions

Drug interactions may occur if used together with other drugs. Please consult your physician or pharmacist for details. 11.11 Expert Comments

1. (1) Consumption: Symptoms include red cheeks, dry mouth, excessive dreams, spermatorrhea in dreams, restless nights, dizziness and upset, five-heart hot flashes, yellowish and hot urine, Red tongue with little coating, thready and rapid pulse. (2) Toothache: Symptoms include red cheeks, dry mouth, hot flashes and night sweats, spermatorrhea, low back pain, red tongue, and thready pulse. (3) Bloody stranguria: Symptoms include prolonged hematuria, dark red blood, burning and painful urination, waist pain, hot flashes, nocturnal emissions, deficiency and irritability, thin, dry and red tongue, and a heavy and thready pulse.

2. Indications for application: The key points of syndrome differentiation of Zhibai Dihuang Pills are liver and kidney yin deficiency, and deficiency of fire leading to inflammation. The main symptoms are soreness and weakness in the waist and knees, tinnitus and deafness, night sweats, bone steam and hot flashes, red cheeks and dry throat, red tongue with less coating, and thready and rapid pulse.

3. Adverse reactions: 1 case of oral administration of Zhibai Dihuang Pills showed *** itching, tingling, hemorrhoids, blood in the stool, and nasal mucosa oozing.

4. Note when using: People with spleen deficiency and loose stools and indigestion should not use it.

5. New clinical uses: (1) Treatment of single benign thyroid nodules: It is reported that the application of Zhibai Dihuang Pills to treat patients with single benign thyroid nodules has a significant effect. Method: Simply take Zhibai Dihuang Pills, 9g/time; or its concentrated pills, 8 pills/time, 3 times/day, 90 days as a course of treatment. Effect: Zhibai Dihuang Pills were used to treat 26 patients with single benign thyroid nodules. After 1 to 2 courses of treatment, 20 cases were cured (those with disappeared tumors confirmed by surgical examination and B-ultrasound examination), and those who were effective (relative to Significantly reduced before treatment) in 4 cases, and ineffective (no change before and after treatment) in 2 cases, the total effective rate was 92%. Most patients will experience curative effect after one course of treatment. (2) Treatment of ototoxicity symptoms caused by aminoglycosides: Zhibai Dihuang Pills was used to treat 44 patients with ototoxicity symptoms caused by aminoglycosides, and achieved remarkable results.

Method: Take Zhibai Dihuang Pills orally, 2 pills/time, once in the morning and once in the evening, with warm water. Effect: Among the 44 cases, 32 cases were cured after taking the medicine for 2 to 5 days (including 16 cases of simple tinnitus and 16 cases of tinnitus with vertigo); 10 cases were improved after 5 to 10 days of taking the medicine (including 16 cases of tinnitus and vertigo). 8 cases, 2 cases with tinnitus accompanied by hearing loss); 2 cases with no effect after taking the medicine for more than 15 days (no obvious changes before and after treatment). The overall effectiveness rate is 95%. (3) Treatment of nocturnal emissions: Zhibai Dihuang Pills were used to treat 36 cases of nocturnal emissions due to kidney deficiency. After 3 to 5 courses of treatment, 29 cases were cured, 5 cases improved, and 2 cases were ineffective. The total effective rate was 945 . Method: Take Zhibai Dihuang Pills orally, 2 pills/time, once a day in the morning, noon and evening, with warm water. During treatment, avoid spicy food and excessive exertion. One course of treatment lasts for 20 days. (4) Treatment of male infertility: Some people used Zhibai Dihuang Pills to treat 55 cases of male infertility caused by yin deficiency and excessive fire. After 4 to 6 courses of treatment, 48 cases were cured and 7 cases were ineffective. Method: Take Zhibai Dihuang Pills orally, 2 pills/time, once in the morning and once in the evening with warm water. 30 days is a course of treatment. Generally, the effect can be seen after taking the medicine for 1 to 2 courses. While taking the medicine, it is advisable to abstain from sexual intercourse. (5) Treatment of insomnia: Zhibai Dihuang Pills were used to treat 12 patients with insomnia caused by yin deficiency and excessive fire. After 3 to 5 courses of treatment, 9 cases were cured and 3 cases were ineffective. The cure rate is 75%. Method: Take Zhibai Dihuang Pills orally, 2 pills/time, 3 times/day, with warm water. One course of treatment lasts for 20 days. (6) Treatment of senile Sjogren’s disease: Some people used Zhibai Dihuang Pills to treat 19 cases of senile Sjogren’s disease (dry mouth, tongue, nose, and dry stools). After 10 to 15 days of treatment, 16 cases were cured, 2 cases improved, and 10 cases were ineffective. 1 case, the total effective rate is 95%. Method: Take Zhibai Dihuang Pills orally, 2 pills/time, once a day in the morning, noon and evening, with warm water. It usually takes 3 to 5 days to take the medicine to take effect. (7) Treatment of diabetes: Zhibai Dihuang Pills were used to treat 21 patients with diabetes due to yin deficiency and fire excess. After 3 to 5 courses of treatment, 17 cases were cured, 3 cases improved, and 1 case was ineffective. The overall effectiveness rate is 95%. Method: Orally take Zhibai Dihuang Pills, 2 pills/time, once in the morning and once in the evening, with warm water. A course of treatment lasts for 30 days, and obvious effects can be achieved after taking the medicine for 10 to 15 days. (8) Treatment of nephrotic syndrome: This disease is a clinical syndrome caused by various causes. The clinical manifestations are massive proteinuria, hypoalbuminemia, hyperlipidemia and varying degrees of edema. Nephrotic syndrome mostly belongs to the categories of "edema", "deficiency tuberculosis", "low back pain" and other categories in Chinese medicine. Some people use Zhibai Dihuang Pills to treat patients with nephrotic syndrome, and the effect is quite good. Usage: Take Zhibai Dihuang Pills orally, 2 pills/time, 3 times/day, with warm water. 15 days is a course of treatment. Efficacy: Zhibai Dihuang Pills were used to treat 16 patients with nephrotic syndrome. After 2 to 4 courses of treatment, 13 cases were cured, 2 cases improved, and 1 case was ineffective. The total effective rate was 94%. Generally, the medication begins to take effect in about 1 week. (9) Treatment of acute urinary tract infection: Zhibai Dihuang Pills were used to treat 22 patients with acute urinary tract infection. After 6 to 12 days of treatment, 18 cases were cured, 2 cases improved, and 2 cases were ineffective. The overall effectiveness rate is 91%. Usage: Take Zhibai Dihuang Pills orally, 2 pills/time, 3 times/day, with warm water. (10) Treatment of refractory night sweats: Modern medicine believes that this disease is caused by autonomic nervous system dysfunction. According to traditional Chinese medicine, intractable night sweats are caused by insufficient lung qi, disharmony between yin and yin, and excessive fire. Therefore, the treatment with Zhibai Dihuang Pills has better results. Usage: Oral Zhibai Dihuang Pills, 2 pills/time, once in the morning and once in the evening, 10 days is a course of treatment. Effect: Zhibai Dihuang Pills were used to treat 15 patients with refractory night sweats. After 2 to 3 courses of treatment, 12 cases were cured, 2 cases improved, and 1 case was ineffective. The overall effectiveness rate is 93%. (11) Treatment of recurrent hematospermia: It is reported that 30 patients with recurrent hematospermia were treated with Zhibai Dihuang Pills. One course of treatment was 7 days, and the drug was generally taken for 2 to 3 courses. Results: Among the 30 cases, 11 cases were cured (clinical symptoms disappeared, *** and prostatic fluid tests were normal, and there was no recurrence after six months of follow-up); effective patients (clinical symptoms disappeared, ***, and prostate fluid tests were normal, but after 2 to 3 Recurred after 13 months); 6 cases were ineffective (clinical symptoms did not improve significantly, and test results of prostate fluid and prostatic fluid also showed no significant improvement). During the treatment period, avoid alcohol and spicy products, and be careful during sexual intercourse. (12) Treatment of menopausal syndrome: It is reported that Zhibai Dihuang Pill (decoction) is used to treat menopausal syndrome. For those who are upset and irritable, add turmeric, bupleurum, and Chuanlian; for those with palpitations, insomnia, or restlessness, add Date kernels, albizia bark, calcined keel bones, calcined oysters; for dizziness, soreness of waist and knees, and hot palms and soles, add roasted turtle shell, wolfberry, achyranthes bidentata, and ground bone skin. Half a month is one course of treatment. Results: Among 80 cases, 56 cases were clinically cured, 21 cases improved, and 3 cases were ineffective. The total effective rate was 96%.

11.12 Remarks