Usage and dosage Individualized dosage, subcutaneous injection. In hemodialysis, it is administered by intravenous injection.
Adverse reactions occasionally showed signs of thrombocytopenia, thrombosis and bleeding, and skin necrosis, hematoma, allergic reaction and increased transaminase occurred at the injection site.
Patients with any history of thrombocytopenia caused by heparin, bleeding tendency and symptoms related to coagulation disorder, organic injury prone to bleeding and acute bacterial endocarditis are prohibited. Precautions Pay attention to monitoring platelet count. During hemodialysis, the dosage was adjusted when the activity of anticoagulant factor Xa was lower than 0.4 IU/mL or higher than 1.2 IU/mL. It should be used with caution after brain or spinal surgery in patients with liver and renal insufficiency, bleeding-prone organic lesions, choroidal and retinal vascular history.
No teratogenic effect of low molecular weight heparin was found in the animal studies of pregnant women and lactating women. Breastfeeding: Because gastrointestinal absorption is impossible for newborns at first, it is not taboo for lactating mothers to use low molecular weight heparin.
There is no special information on children's medication.
Related disease thromboembolic disease blood clot formation
The component is low molecular weight heparin calcium, which is the calcium salt of glucosamine (heparin) fragment obtained from intestinal mucosa.
France where the dosage form injection is produced.
Store below 30℃ and keep away from light.
Clear or slightly turbid colorless or yellowish clear liquid.
GlaxoSmithKline (Tianjin) Co., Ltd.
Pharmacology and Toxicology Low molecular weight heparin is a kind of low molecular weight heparin, which is depolymerized from ordinary heparin with antithrombotic and anticoagulant effects. It has high activity of anticoagulant factor ⅹ A (97 iu/ml) and low activity of anticoagulant factor Ⅱa or antithrombin (30IU/ml). The ratio of these two activities is 3.2. According to the recommended dosage for different indications, low molecular weight heparin does not prolong the bleeding time. At the preventive dose, it does not significantly change APTT.
Drug interaction should not be combined with acetylsalicylic acid (used in antipyretic and analgesic doses), non-steroidal anti-inflammatory and analgesic drugs, dextran 40 and ticlopidine. Cautiously combined with glucocorticoid (systemic use) and acetylsalicylic acid (used at antiplatelet dose).
OTC category no
Is it imported? Yes.
Medical insurance category no
Pharmacokinetics The study of pharmacokinetic parameters is based on the change of anticoagulant factor ⅹ A activity in plasma. Bioavailability: After subcutaneous injection, low molecular weight heparin is absorbed quickly and can reach nearly 100% absorption. The plasma peak was reached about 3 hours after use. Distribution: the half-life of anticoagulant factor ⅹ A activity in low molecular weight heparin is longer than that in ordinary heparin, about 3.5 hours. Compared with anticoagulant factor ⅹ A, the activity of anticoagulant factor Ⅱa disappeared quickly in plasma. Clearance: mainly through the kidney in the form of a small amount of metabolism or prototype clearance.
This entry is helpful to me
nine
Related terms:
What are the related terms? Let me improve them.
Open classification:
medicines and chemical reagents
Co-editor:
wanghong4486
If you think this entry needs to be further improved, Encyclopedia welcomes you to participate in editing the entry. Before you start editing, you can also learn how to edit the entry statistics.
Number of visits: about 1 1 12 times.
Number of edits: 1
Last updated: 2008-09- 10
Founder: wanghong4486
Latest developments
Small orange lamp:
About the little orange lamp:
Brief introduction of small orange lantern activity
Love transmission, invite you to participate.
Official space for small orange lantern activities