zhī zǐ jīn huā wán
2 Gardenia Jinhua Wan (栀子金花丸)2.1 NameGardenia Jinhua Wan ( 栀子金花丸)
Zhizi Jinhua Wan ( 栀子金hua Wan
) p> 2.2 PrescriptionGardenia gardenia 116g, Huanglian 4.8g, Scutellaria baicalensis 192g, Cyperus rotundus 60g, Rheum palmatum 116g, Honeysuckle 40g, Zhi Mu 40g, Smallpox pollen 60g
2.3 Method of PreparationThe above eight flavors, crushed into fine powder, sieve, mix well, and then pills with water, drying, that is, the product.
2.4 Character
This product is yellow to yellow-brown water pill; bitter taste.
2.5 Identification(1) take this product, placed under the microscope: bast fibers yellowish, pike-shaped, thick wall, pore grooves fine (Scutellaria baicalensis). Fiber bundles are bright yellow, with slightly thicker walls and obvious pores (Huang Huanglian). Fiber bundles bright yellow, the surrounding cells contain calcium oxalate square crystals, forming crystal fibers, the wall of the crystal-containing cells lignified and thickened (Phellodendron Bark). Calcium oxalate needle crystals in bundles or scattered, 26-110μm long (robinia). Calcium oxalate cluster crystals are large, 60-140μm in diameter (rhubarb). The seed coat stone cell yellow or light brown, much broken, complete long polygonal, oblong or irregular shape, wall thick, have big round grain hole, cell cavity brownish red (gardenia). The pollen grain is spherical, about 76μm in diameter, the outer wall with spiny sculpture, with 3 germination holes (honeysuckle). The ciliated pore conduit is large, more broken, some ciliated pores are hexagonal or rhomboid, arranged closely (pollen).
(2) take this product 2g, research fine, add ether 10ml, shake for 10 minutes, discard ether, dregs volatile dry, add ethyl acetate 20ml, heating reflux for 1 hour, take out, let cool, filtration, dregs standby, filtrate evaporation, residue add methanol 2ml to make dissolution, filtration, filtrate as test solution. Take gardenia glycoside control product, add methanol to make 1mg solution per 1ml, as control product solution. According to the thin layer chromatography method (2010 edition pharmacopoeia a appendix Ⅵ B) test, absorb the above two kinds of solution each 5 μl, respectively point in the same silica gel G thin layer plate, with ethyl acetate - acetone - formic acid - water (10:6:2:0.5) as the unfolding agent, unfolding, take out, drying, spraying with 10% ethanol sulfate solution, and heated at 105°C for 10 min. In the chromatogram of the test article, in the corresponding position with the chromatogram of the control article, the same color spots.
(3) take [identification] (2) under the ethyl acetate extracted dregs, washed with ethyl acetate 2 times, each time 5 ml, discard the ethyl acetate solution, dregs volatile ethyl acetate, add methanol 15 ml, soak for 30 minutes, shaking, filtration, filtrate evaporation, residue with methanol 2 ml to make the dissolution, filtration, filtrate as a solution for the test product. Another take baicalin control, add methanol to make a solution containing 1mg per 1ml, as the control solution. According to thin-layer chromatography (2010 Pharmacopoeia, Appendix VI B), absorb 8 μl of the test solution, 5 μl of the control solution, were spotted on the same silica gel G thin-layer plate, with ethyl acetate - butanone - formic acid - water (5: 3: 1: 1) as an unfolding agent, unfolding, take out, dry. , sprayed with 1% ferric chloride ethanol solution. In the chromatogram of the test article, in the corresponding position with the chromatogram of the control article, show the same color spots.
(4) take 3g of this product, research fine, add 25% sulfuric acid solution 10ml, heat reflux for 1 hour, cool, add 15ml of trichloromethane, heat reflux for 30 minutes, divided into trichloromethane layer, evaporated, the residue of the addition of 2ml of methanol to make soluble, filtered, the filtrate as a test solution. Another 0.6g of rhubarb control herb was taken, and the same method was used to make control herb solution. According to the thin layer chromatography (2010 version of Pharmacopoeia, Appendix VI B), absorb the above two solutions of 5μl, respectively, point in the same sodium carboxymethyl cellulose as the binder of silica gel H thin layer plate, with petroleum ether (30 ~ 60 ℃) - ethyl formate - formic acid (15:5:1) of the upper layer of the solution as the unfolding agent, unfolding, remove, drying. Remove and dry. In the chromatogram of the test product, in the corresponding position with the chromatogram of the control herb, the same five yellow spots; placed in the ammonia vapor fumigation, the spots become red.
(5) take 5g of this product, research fine, add 25ml of methanol, ultrasonic treatment for 20 minutes, filtration, filtrate is added to the neutral alumina column (100-200 mesh, 5g, inner diameter of 1cm), collect the effluent, evaporate to dryness, the residue of the addition of 2ml of methanol to make soluble, as a test solution. Also take 0.05g each of Phellodendron Bark and Phellodendron Bark control herb, add 5ml of methanol respectively, ultrasonic treatment for 20 minutes, filtered, filtrate add methanol to 5ml, as a solution of control herb. Then take berberine hydrochloride control, add methanol to make a solution containing 0.5mg per 1ml as control solution. According to thin-layer chromatography (2010 Pharmacopoeia, Appendix VI B), 2 μl of the test solution, 1 μl of the control solution and 1 μl of the control solution were pipetted onto the same high-performance silica gel G thin-layer plate, and then extracted with toluene-isopropanol-ethyl acetate-methanol (12.5 ml) and concentrated ammonia test solution (12.5 ml). -Concentrated ammonia test solution (12:3:6:3:1) was used as the unfolding agent, placed in an unfolding cylinder saturated with ammonia vapor, unfolded, removed, dried, and examined under UV light (365 nm). In the chromatogram of the test article, in the position corresponding to the chromatogram of the control herb, fluorescent spots of the same color are shown; in the position corresponding to the chromatogram of the control article, fluorescent spots of the same color are shown.
2.6 InspectionIt should comply with the relevant provisions under pills (2010 version of the Pharmacopoeia, a Appendix I A).
2.7 Determination of contentDetermined by high performance liquid chromatography (2010 Pharmacopoeia, Appendix VI D).
2.7.1 Chromatographic conditions and system applicability testWith octadecyl silane bonded silica gel as filler; With acetonitrile - water (11:89) as mobile phase; Detection wavelength is 238 nm. theoretical plate number according to gardenia glycoside peak calculation should not be less than 2000.
2.7.2 Preparation of the control product solutionTake the gardenia glycoside control product appropriate amount. Precision weighing, add 50% methanol to make a solution containing 30μg per 1ml, that is obtained.
2.7.3 Preparation of test solutionTake appropriate amount of this product, research fine, take about 1g, precision weighing, put in a stoppered conical flask, precision add 50% methanol 50ml, close the plug, weighing, ultrasonic treatment (power 300W, frequency 50kHz) for 20 minutes, let cool, and then weighing, make up for the loss of weight with 50% methanol, shaking, filtration, precision measurement of renewed filtrate 10 ml, placed in a 25 ml measuring flask, add 50% methanol to the scale, shake well, filter, take the filtrate, that is obtained.
2.7.4 DeterminationPrecisely take 10μl of control solution and test solution respectively, inject into liquid chromatograph, and then determine, it is obtained.
Each 1g of this product contains gardenia to gardenia glycoside (C17H24O10), shall not be less than 2.8mg.
2.8 Functions and IndicationsClearing away heat and diarrhea, cooling blood and detoxification. It is used in treating heatiness of the lung and stomach, mouth and tongue sores, swollen and painful gums, redness and dizziness of the eyes, sore throat, epistaxis and constipation.
2.9 Dosage and AdministrationOral. 9g once, once a day.
2.10 CautionUse with caution in pregnancy.
2.11 Specifications9g per bag
2.12 StorageSealed.
2.13 VersionChinese Pharmacopoeia 2010 Edition
3 Gardenia Jinhua Pills 3.1 NameGardenia Jinhua Wan
3.2 PinyinZhizi Jinhua Wan
3.3 Formulation9g per bag
3.4 CharacteristicsGardenia Jinhua Pills are yellow to yellow-brown water pills with bitter taste. Yellowish brown water pill; bitter taste.
3.5 Main ingredients of Gardenia jasminoides pillsGardenia jasminoides, Coptis chinensis, Scutellaria baicalensis, Cyperus rotundus, Rheum palmatum, Honeysuckle, Zhi Mu, Smallpox pollen
3.6 Functions of Gardenia jasminoides pillsClearing away heat and diarrhea, cooling the blood, detoxifying the toxin. It is used in treating heatiness of lung and stomach, mouth and tongue sores, swollen and painful gums, redness and dizziness of the eyes, sore throat, epistaxis, and constipation of stool.
3.7 Usage and dosage of Gardenia jasminoides pillsOral. 9g once a day.
3.8 Precautions1. Avoid smoking, alcohol and spicy food.
2. It is not advisable to take tonic Chinese medicine at the same time.
3. People with hypertension, heart disease, liver disease, diabetes, kidney disease and other chronic diseases should take it under the guidance of a physician.
4. After taking the medicine, the number of stools increased and not shaped, should be appropriate to reduce the dosage.
5. Pregnant women should be cautious, children, lactating women, the elderly and weak, and those with spleen deficiency and loose stools should be taken under the guidance of a physician.
6. Strictly according to the dosage, this product should not be taken for a long time.
7. If the symptoms are not relieved after 3 days of taking the medicine, you should go to the hospital.
8. This product is prohibited for those who are allergic to this product, and allergic individuals should be cautious.
9. The use of this product is prohibited when the properties of the product have changed.
10. Children must be used under adult supervision.
11. Keep this product out of the reach of children.
12. If you are using other drugs, consult your physician or pharmacist before using this product.
3.9 Drug interactionsDrug interactions may occur if used with other drugs, consult your physician or pharmacist for details.
3.10 RemarksPlease read the instruction manual carefully and use it according to the instructions or purchase and use it under the guidance of a pharmacist.
4 "Beijing Municipal Chinese medicine prescription anthology" of gardenia jinhua pill 4.1 Name of the formulagardenia jinhua pill
4.2 Compositiongardenia jasminoides 288 taels, cypress 144 taels, yellow dock 12 taels, scutellaria baicalensis 288 taels, pollen of smallpox 144 taels, rhubarb 288 taels, and Zhi Mu 96 taels.
4.3 Functions
Beijing traditional Chinese medicine prescription anthology Gardenia jinhua pill has the effect of diarrhea heat, moistening dryness, generating fluids and quenching thirst.
4.4 Indications
Beijing traditional Chinese medicine prescription anthology of gardenia jinhua pill is used for treating dizziness, bleeding from dry nose, toothache and pharyngeal swelling, mouth and tongue sores.
4.5 Usage and dosage of Gardenia jasminoides pills2 money per dose, 2 times a day, warm water.
4.6 Preparation methodThe above is fine powder, over Luo, with cold water into small pills.
4.7 ContraindicationsAvoid spicy food. Pregnant women should not take it.
5 Xuanming Lecture Volume 4 of Gardenia Golden Flower Pill 5.1 Name of the formulaGardenia Golden Flower Pill
5.2 Alias of Gardenia Golden Flower PillShiji Detoxification Pill, Golden Flower Pill, Small Golden Flower Pill, Sanguine Golden Flower Pill, Big Golden Flower Pill
5.3 CompositionHuanglian half a tael, Huangbai half a tael, Scutellaria Baicalensis half a tael, Gardenia jasminoides half a tael.
5.4 Indications"Xuan Ming Lecture" Volume 4 of Gardenia Golden Flower Pill is used for the treatment of all kinds of fever in and out of the country, bedtime sweating and biting teeth, sleepy speech and palpitation, drowning and blood drenching, coughing blood and epistaxis, thinness and headache, bone vaporization, impotence of the lungs and panting and coughing.
5.5 Usage and dosage of Gardenia jasminoides pillsTake 2030 pills each, with fresh water. For children, take 35 pills as big as hemp seeds.
5.6 PreparationThe above is powdered and made into pills with water, as big as small beans.
5.7 NotesShizi detoxification pills (original book of the same volume), golden flower pills ("living method of the machine"), small golden flower pills ("life preservation song bracket" Volume 10), three golden flower pills ("medical prescription collection"), large golden flower pills ("life preservation collection" Volume).
6 Gardenia and Golden Flower Pill of "Poor Countryside Convenient Formula" 6.1 Name of the formulaGardenia and Golden Flower Pill
6.2 IngredientsGardenia jasminoides 3 taels, Scutellaria baicalensis 2 taels, Cyperus vulgaris 2 taels, Macrocephalos 2 taels, apricot kernel 1 tael, Semen xia 1 tael, Platycodon grandiflorus 1 tael, Rhizoma coptidis 4 qian, Mentha arvensis 8 qian.
6.3 Treatment
Poor Township Convenient Formula of Gardenia Golden Flower Pill is used to treat fire disease with dry tongue and mouth.
6.4 Usage and dosage of Gardenia jasminoides pillsTake 3 qian per dose, and send it down with light ginger soup at the time of eating.
6.5 Preparation method