The causes of pancreatitis are numerous and vary from region to region. 1. Biliary system diseases Bile duct stones are the most common, in addition, biliary tract inflammation, bacterial toxins release kinetic peptide can be activated through the biliopancreatic lymphatic transport branch of pancreatic digestive enzymes causing acute pancreatitis. In addition, biliary roundworms, sphincter of Oddi edema, spasm, fibrous stenosis, malformations, and tumors can cause obstruction of the lower end of the common bile duct and the pancreatic duct, leading to chronic pancreatitis. 2. Alcohol or drugs Long-term alcoholism can stimulate the increase in protein content in the pancreatic fluid, the formation of protein "embolism" obstruction of the pancreatic duct; at the same time, alcohol can stimulate the duodenal mucosa to make the papillae edema, impede the pancreatic fluid discharge. Some drugs and poisons can directly damage pancreatic tissue such as azathioprine, adrenocorticotropic hormone, tetracycline, thiazide diuretics, L-asparaginase, organophosphorus insecticides, and so on. 3. Infections Many infectious diseases can complicate pancreatitis, the symptoms are not obvious, after the primary disease heals, pancreatitis subsides on its own, common mumps, viral hepatitis, infectious mononucleosis, typhoid fever, septicemia, and so on. 4.Other diseases The chance of pancreatitis in patients with familial hyperlipidemia is significantly higher than that of normal people. Atherosclerosis and periarteritis nodosa can lead to narrowing of the arterial lumen and insufficient blood supply to the pancreas. When duodenal Crohn's disease affects the pancreas, it can cause pancreatic vesicle destruction to release and activate pancreatic enzymes to cause pancreatitis. Pancreatic duct obstruction, pancreatic duct stones, stenosis, tumors, etc. can cause exuberant secretion of pancreatic juice, increased intra-pancreatic duct pressure, rupture of small branches of the pancreatic duct and pancreatic follicles, and leakage of pancreatic juice and digestive enzymes into the mesenchyme, which causes acute pancreatitis. In a few cases of pancreatic isolation, the main pancreatic duct and the parapancreatic duct are shunted and poorly drained, which may also be associated with acute pancreatitis. In hyperadrenocorticism, corticosterone can increase the secretion and viscosity of the pancreas, leading to impaired excretion of pancreatic fluid and increased pressure causing pancreatitis. 5. Nutritional disorders Low-protein diets can lead to chronic pancreatitis, mostly found in Southeast Asia, Africa and Latin America. In recent years, it has been found that there is a correlation between high-fat intake and the development of pancreatitis. Animal experiments have also proved that high-fat intake sensitizes the pancreas and makes it easy to develop chronic pancreatitis. Patients in Europe, America and Japan are often associated with high fat intake. 6. Genetic factors Hereditary pancreatitis (hereditary pancreatitis) is less common and is chromosomally dominant. Psychiatric, genetic, allergic and allergic reactions, diabetic coma and uremia are also factors that can cause acute pancreatitis. 7. Trauma and surgery are common causes of acute pancreatitis. Chronic pancreatitis may occur only after severe trauma or injury to the main pancreatic duct. Other relevant disease information for pancreatitis: ?6?1 What tests should be done for ?6?1 pancreatitis? What diseases is ?6?1 pancreatitis easily confused with? What are the signs of ?6?1 pancreatitis and how is it diagnosed? How should pancreatitis be treated? What are the complications of ?6?1 pancreatitis? How should?6?1 pancreatitis be prevented and cared for?