Antelope horn is the horn of Saiga antelope (high-nosed antelope) in Bovine family. Mainly produced in Kazakhstan, Tajikistan, Uzbekistan, Russia and other countries. In China, only northwest Xinjiang has a small amount of production. For the protection of medicinal resources, the State Council promulgated the Regulations on the Protection and Management of Wild Medicinal Resources as early as 1987 10.30, and designated Saiga antelope as a first-class protected wild medicinal species. The first level means "endangered rare wild medicinal species". Article 6 of the Management Regulations also stipulates that "it is forbidden to hunt wild medicinal species under first-class protection". At present, except for a small amount of antelope horn circulating in the market, most of them are imported from abroad, which is expensive, which has brought great impact on the wide application of antelope horn in clinic. Therefore, finding a substitute for antelope horn has become the focus of medical workers.

1 Discussion on doctors of different generations

Antelope horn tastes cold and salty, enters the liver and heart meridian, and is a valuable Chinese medicine with magical curative effect. The antelope horn is mentioned in Shennong's Materia Medica, which "focuses on improving eyesight, benefiting qi and nourishing yin, eliminating pathogenic blood and evil spirits, which is ominous, reassuring and often sleepless." In Compendium of Materia Medica, antelope horn "calms the liver and relaxes tendons, calms the nerves, promotes blood circulation and purges qi, eliminates pathogenic factors and detoxifies, and treats eclampsia and spasm." "A Bie Lu of Famous Doctors" also pointed out that "antelope horn can cure cold and heat when it is cold, and heat is in the skin, warming the wind and injecting poison into the bone, eliminating evil spirits, frightening dreams, being crazy but not coming out, choking on food."

1. 1 antelope horn is mainly composed of keratin, calcium phosphate and insoluble inorganic salts. After acid hydrolysis, antelope horn contains various amino acids such as isoleucine, leucine, phenylalanine, tyrosine and alanine. In addition, it also contains phospholipids such as lecithin, cephalin, sphingomyelin, phosphatidylserine and phosphatidylinositol.

1.2 Modern pharmacological research shows that antelope horn has sedative, anticonvulsant, antipyretic, antihypertensive, antibacterial and antiviral effects. Clinically, antelope horn is used to treat dizziness, headache, hypertension and other diseases caused by high fever, convulsion, primary thrombocytopenic purpura and disturbance of liver fire.

Clinical efficacy of 1.3

1.3. 1 Yan Yongchao et al. [1] 200 cases of exogenous high fever were treated with antelope horn. It was found that the effective rate of fever caused by bacterial infection, especially virus infection, was 9 1, and the antipyretic effect of drugs was mild and lasting, and it was not easy to rise repeatedly without side effects.

1.3.2 Lin [2] treated 889 cases of epilepsy, including 5 16 males and 373 females, with a course of 1 ~ 33 years. The result is remarkable.

1.3.3 is used to reduce blood pressure. Xu [3] 102 patients with hypertension were treated with compound antelope horn jiangya oral liquid. The total effective rate was 77.45, and the decreasing value was 3.7/2.8kpa(p