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Why the cultured puffer fish is nontoxic?
Because artificial farming has changed the food chain of puffer fish.

Tetrodotoxin is not produced by puffer fish itself, but comes from a special kind of bacteria. The bacteria enter the puffer fish by parasitizing on plankton, or live directly in the puffer fish. The puffer fish can tolerate this toxin and use it as a means of mutual destruction with its natural enemies. Artificial culture changes the food chain of puffer fish, so puffer fish is non-toxic.

Brief introduction of puffer fish

Pufferfish is also known as bubble fish, commonly known as: river fish dolphin, tingba fish, and gas drum. It is a warm-water marine benthic fish belonging to the class teleosteichthys, suborder Megalobrama and family Megalobrama, which is distributed in the western part of the North Pacific Ocean and has been caught in various sea areas in China. The false-eyed oriental dolphin often enters the waters in the middle and lower reaches of the Yangtze River and the Yellow River, while the dark-striped oriental dolphin can also enter rivers or settle in freshwater lakes.

There are many species of puffer fish, among which the most common ones are the oriental dolphin with insect pattern, the purple oriental dolphin, the oriental dolphin with yellow fin, the oriental dolphin with red fin, the oriental dolphin with false eye and the oriental dolphin with dark pattern, and the average body length is 70-500 mm, among which the oriental dolphin with red fin has been found to be 750 mm.