Sheep intestinal toxemia, also known as the fastidious disease, is also an acute infectious disease in the clostridium difficile. The clinical symptoms of the disease are similar to those of FMD, so it is called "FMD-like", and the kidneys of most diseased sheep become soft after death, so it is also called "soft kidney disease".

This disease is also mainly sheep, especially about 1 year old and obese sheep incidence more, pastoral areas often occur in the spring and summer and autumn. Agricultural areas are more common in the summer and fall harvest season. Generally for the sporadic epidemic.

The difference between sheep enterotoxemia and sheep epidemic is mainly the onset of the season and the degree of true gastric hemorrhage. Sheep fast disease onset season is often fall, winter and early spring cold season, while sheep enterotoxemia in the spring and summer at the turn of the green rush and fall rapeseed maturity occurred. In sheep, there is usually obvious hemorrhagic inflammatory damage in the true stomach, while in sheep with intestinal toxemia, there is no or only slight damage. In addition can be distinguished by bacteriological examination.