fù z ǐ l ǐ zh! ng wá n2 English Reference
Fuzi Lihong Wan [21st Century Bilingual Science and Technology Dictionary]
Fuzi Lihong Pills [Chinese Medicine Terminology Examination Committee. Chinese Medicine Terminology (24)]
Fuzi Lihongwan [Terminology Committee of Traditional Chinese Medicine. Terminology of Traditional Chinese Medicine (24)] 3 National Essential Drugs
National Essential Drugs Retail Guidance Price Information Related to Fuzi Lizhong Pill
Serial Number Essential Drugs
Directory Serial Number Drug Name Dosage Specification Unit Retail refers to
Guide Price Category Remarks 243 2 Fuzi Lizhong Pill 9g Pill .6 Chinese Patent Medicine Part * 244 2 Fuzi Lizhong Pill 54g bottle 3.2 Chinese patent medicine part 245 2 Fuzi Lizhong Pill 6g bottle 3.5 Chinese patent medicine part 246 2 Fuzi Lizhong Pill Honey Pill 12g bottle 6.6 Chinese patent medicine part 247 2 Fuzi Lizhong Pill Shuimi Pill 6g bag .55 Chinese patent medicine part * △ 248 2 Fuzi Lizhong Pill 3g bottle 2.4 Chinese patent medicine part 249 2 Fuzi Lizhong Pill 36g bottle 2.9 Chinese patent medicine part 25 2 Fuzi Lizhong Pill 4g bottle 3.2 Chinese patent medicine part 251 2 Fuzi Lizhong Pill 48g bottle 3.8 Chinese patent medicine part 252 2 Fuzi Lizhong Pill Shuimi Pill 54g bottle 4.2 Chinese patent medicine part 253 2 Fuzi Lizhong Pill Shuimi Pill 6g bottle 4.6 Chinese patent medicine part 254 2 Fuzi Lizhong Pill Shuimi Pill 72g bottle 5.5 Chinese patent medicine part 255 2 Fuzi Lizhong Pill Concentrated Pill 2 Pill Bottle 6.3 Chinese patent medicine part * △ 256 2 Fuzi Lizhong Pill Concentrated Pill 192 Pill Bottle 6.1 Chinese Patent Medicine Part 257 2 Fuzi Lizhong Pill Concentrated Pill 36 Pill Bottle 11.1 Chinese Patent Medicine Part
Note:
1. The specifications of dosage forms marked with "*" in the remarks column in the table are representative products.
2. The specifications of dosage forms marked with "△" in the remarks column in the table and other specifications of the same dosage form are provisional prices.
3. The dosage form specifications are indicated in the remarks column. The prices of other specifications in this dosage form are based on the same usage and dosage, and are calculated according to the Drug Price Comparison Rules.
4. The "honey pills" marked in the dosage form column in the table include small honey pills and big honey pills. 4 Overview < P > Fuzi Lizhong Pill is the prescription name, and there are about 2 prescriptions with the same name.
Fuzi Lizhong Pill, a Chinese patent medicine, mainly consists of Radix Aconiti Lateralis Preparata, Radix Codonopsis, Atractylodis Rhizoma (parched), Zingiberis Rhizoma and Radix Glycyrrhizae [1]. Has the effects of warming middle warmer and strengthening spleen. Used for spleen and stomach deficiency and cold, epigastric cold pain, vomiting and diarrhea, and tepid hands and feet.
The Drug Standards of the Ministry of Health of the People's Republic of China contains the ministerial standards of Fuzi Lizhong Pill.
Pharmacopoeia of the People's Republic of China (21 edition) records the pharmacopoeia standard of Fuzi Lizhong Pill. 5 Fuzi Lizhong Pill in Volume 5 of Taiping Huimin Hejiju Recipe 5.1 Another name of Fuzi Lizhong Pill < P > Fuzi Baizhu Pill, Lizhong Pill and Dajiang Jianwan 5.2 are composed of < P > Fuzi (processed, peeled navel) 3 Liang, Ginseng (removed reed) 3 Liang, dried ginger (processed) 3 Liang, Glycyrrhiza (roasted) 3 Liang, Atractylodis Rhizoma 3 Liang. 5.3 Efficacy < P > Fuzi Lizhong Pill in Volume 5 of Taiping Huimin Hejiju Prescription has the effects of warming spleen and dispelling cold, stopping diarrhea and relieving pain. 5.4 indications
Fuzi Lizhong Pill, Volume 5 of Taiping Huimin Heji Bureau Prescription, is indicated for deficiency of spleen and stomach, anorexia and fullness, abdominal pain and vomiting, faint pulse, cholera twitching, or headache due to cold, and all kinds of cold. 5.5 Usage and dosage of Fuzi Lizhong Pill < P > Take 1 pill each time, dissolve it with 1 cup of water, fry it to 7 points, and take it hollow and slightly warm before eating. 5.6 the preparation method
is fine powder, refined honey is pills, and every two pills are 1 pills. 5.7 contraindications to medication
Avoid eating cold food and pregnant women. 5.8 Pharmacological Action < P > Pharmacological Action of Fuzi Lizhong Pill "Chinese Patent Medicine" (199; 5: 25): Experiments show that Fuzi Lizhong Pill can enhance the cold tolerance of mice and has a significant analgesic effect on abdominal pain caused by acetic acid. Fuzi Lizhong Pill can also obviously antagonize the effects of adrenaline and choline acetate on isolated rabbit intestine, and has a two-way regulation effect on the movement state of isolated intestine, that is, it can obviously antagonize the ileal movement inhibition caused by adrenaline and the ileal spasm caused by acetylcholine. 5.9 Note
Fuzi Baizhu Pill (Volume 12 of Jifeng Puji Recipe), Lizhong Pill (Volume 12 of Confucianism) and Dajiang Jianwan (Volume 395 of Puji Recipe). 6 "Jing Yue Quan Shu" Volume 58 Fuzi Lizhong Pill 6.1 Composition < P > Fuzi Lizhong Decoction removes Atractylodes macrocephala. 6.2 indications
Fuzi Lizhong Pill, Volume 58 of Jingyue Quanshu, is indicated for yin-cold and kidney-qi movement. 6.3 Usage and dosage of Fuzi Lizhong Pill < P > Honey is refined into pills. 7 Pharmacopoeia Standard of Fuzi Lizhong Pill 7.1 Name
Fuzi Lizhong Pill
Fuzi Lihong Wan 7.2 Prescription
Fuzi Lizhong Wan 1g, Codonopsis pilosula 2g, fried atractylodes 15g, Dried Ginger 1g, Glycyrrhiza uralensis Fisch 1g
Method 7.3, pulverizing into fine powder, sieving and mixing. 35-5g of refined honey is added to every 1g of powder, and appropriate amount of water is added to make pills, which are dried to make honeyed pills; Or adding 1～12g refined honey to make small honey pills or big honey pills [2]. 7.4 characteristics
this product is a brown to black honey pill, or a small or large brown honey pill [2]; Slight gas, slightly sweet and spicy taste. 7.5 identification
(1) Take this product and observe it under the microscope: the starch granules are oval, wide oval or irregular in shape, with a diameter of 25 ~ 32 μ m, umbilical punctate, located at the smaller end, with obvious layering (dried ginger [3]). The diameter of the connective mammary duct is 12 ~ 15 μ m, containing fine particles (Codonopsis pilosula). The parenchyma cells around the fiber bundle contain calcium oxalate crystals, forming a product fiber (licorice).
(2) take 4g of this product and grind it; Or take 6g[2] of small honey pills or big honey pills, cut them into pieces, put them in a 5ml round-bottomed flask, add 25ml of water, connect the volatile oil tester, add water from the upper end of the tester until it reaches the scale and overflows the flask, then add 1ml of petroleum ether (6-9℃), heat and reflux for 2h, then cool, and take the petroleum ether layer as the test solution. In addition, .5g of Atractylodes macrocephala control medicinal material was taken, 1ml of ethyl acetate was added, ultrasonic treatment was carried out for 15min, and the supernatant was taken as the control medicinal material solution. According to the test of thin-layer chromatography (Appendix ⅵ b of Pharmacopoeia, 21 edition), 8μl of test solution and 4μl of control medicinal material solution were absorbed, respectively, on the same silica gel G thin-layer plate, developed with petroleum ether (6 ~ 9℃)-ethyl acetate (2: .1) as developing agent, taken out, dried, sprayed with 5% vanillin sulfuric acid solution, and heated until spots appeared. In the chromatogram of the test sample, the main spots with the same color are displayed at the corresponding positions of the chromatogram of the control medicinal materials.
(3) Take 5g of honey pills of this product and grind them into fine powder; Or take 7.5g[2] of small honey pills or big honey pills, cut them into pieces, add 5g of diatomaceous earth, grind them, add 4ml of methanol, perform ultrasonic treatment for 4min, let them cool, filter them, evaporate the filtrate to dryness, dissolve the residue with 2ml of water, shake and extract with n-butanol for twice, 3ml each time, combine the n-butanol extractive solutions, evaporate to dryness, and add 2ml of methanol to the residue for dissolution, so as to serve as the test solution. In addition, 1g of Zingiber officinale was taken as the control medicinal material, and the control medicinal material solution was prepared by the same method. According to the test of thin-layer chromatography (Appendix ⅵ b, Pharmacopoeia, 21 Edition), absorb 5μl of the above two solutions, respectively spot them on the same silica gel G thin-layer plate to make them into strips, and use petroleum ether (6 ~ 9℃)-ethyl acetate-methanol-glacial acetic acid (2: 3: 1: .4) as the developing agent, unfold, take them out, dry them in the air, and place them in an ultraviolet lamp. In the chromatogram of the test sample, fluorescent stripes with the same color are displayed at the positions corresponding to the chromatogram of the control medicinal materials.
(4) Take 1g of Glycyrrhiza uralensis Fisch, add 1ml of methanol, shake for 3min, and let stand, and take the supernatant as the control medicinal solution. According to the test of thin-layer chromatography (Appendix ⅵ b, Pharmacopoeia I, 21 edition), 2μl of the test solution under [Identification ](3) and 5μl of the above-mentioned reference medicinal material solution were respectively spotted on the same silica gel G thin-layer plate, and ethyl acetate-glacial acetic acid-formic acid-water (15: 1: 1: 2) was used as the developing agent, and then developed, taken out, dried and sprayed. In the chromatogram of the test sample, fluorescent spots with the same color appear at the positions corresponding to the chromatogram of the control medicinal materials. 7.6 check 7.6.1 aconitine ***
Take a proper amount of honey pills of this product, grind it, take 25g, or take a proper amount of small honey pills or big honey pills [2], cut it, take 36g, add 4ml of ammonia test solution, mix well, stand for 2 hours, add 6ml of ether, shake it for 1 hour, stand for 24 hours, filter and evaporate the filtrate. Take an appropriate amount of aconitine reference substance, add absolute ethanol to make a solution containing 1.mg per 1ml as reference substance solution. According to the test of thin layer chromatography (Appendix ⅵ b, Pharmacopoeia, 21 Edition), 12μl of test solution and 5μl of reference solution were absorbed, respectively, on the same silica gel G thin layer plate, and dichloromethane (dehydrated by anhydrous sodium sulfate)-acetone-methanol (6: 1: 1) was used as the developing agent, and then developed, taken out, dried and sprayed with dilute potassium bismuth iodide test solution. In the chromatogram of the test sample, the spots corresponding to the chromatogram of the reference substance should be smaller than those of the reference substance, or no spots should appear. 7.6.2 other
should comply with the relevant provisions under pills (appendix ia of Pharmacopoeia I, 21 edition). 7.7 determination of content
according to high performance liquid chromatography (appendix ⅵ d of pharmacopoeia, 21 edition). 7.7.1 chromatographic conditions and system applicability test
Octadecylsilane bonded silica gel is used as filler; Using acetonitrile-.5% acetic acid solution (2: 8) as mobile phase; The detection wavelength is 276nm. The theoretical plate number should be not less than 4 calculated by liquiritin peak. 7.7.2 preparation of reference solution
take a proper amount of liquiritin reference, weigh it accurately, and add methanol to make a solution containing 15μg per 1ml. 7.7.3 Preparation of test solution
Take a proper amount of honey pills of this product, grind them, take about 1.g, and weigh them accurately, or take small honey pills or big honey pills [2] with weight difference, cut them, take about 1.5g, and weigh them accurately; Put it in a conical flask with a stopper, add 5ml of 7% ethanol, tightly plug it, weigh it, perform ultrasonic treatment (power 3W, frequency 25kHz) 45 for 45 minutes, let it cool, make up the lost weight with 7% ethanol, shake it evenly, filter it, and take the filtrate. 7.7.4 determination method
Accurately suck 5μl of the reference solution and the test solution respectively, inject them into the liquid chromatograph, and determine them, thus obtaining the product.
the content of licorice in this product is calculated as liquiritin (C21H22O9), and the honey pill should not be less than .6mg； per 1g; Xiaomi pill shall not be less than .33mg； per 1g; Damiwan shall not be less than 3.mg per pill. [2] 7.8 Functions and indications < P > Warming the middle warmer and strengthening the spleen. Used for spleen and stomach deficiency cold, epigastric cold.